Human Gene CHD9 (ENST00000447540.5) Description and Page Index
Description: Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). (from UniProt Q3L8U1) Gencode Transcript: ENST00000447540.5 Gencode Gene: ENSG00000177200.17 Transcript (Including UTRs) Position: hg38 chr16:53,055,033-53,327,501 Size: 272,469 Total Exon Count: 39 Strand: + Coding Region Position: hg38 chr16:53,156,090-53,324,895 Size: 168,806 Coding Exon Count: 38
ID:CHD9_HUMAN DESCRIPTION: RecName: Full=Chromodomain-helicase-DNA-binding protein 9; Short=CHD-9; EC=184.108.40.206; AltName: Full=ATP-dependent helicase CHD9; AltName: Full=Chromatin-related mesenchymal modulator; Short=CReMM; AltName: Full=Chromatin-remodeling factor CHROM1; AltName: Full=Kismet homolog 2; AltName: Full=PPAR-alpha-interacting complex protein 320 kDa; AltName: Full=Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein; FUNCTION: Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. SUBUNIT: Interacts with PPARA. Probably interacts with ESR1 and NR1I3. INTERACTION: Q07869:PPARA; NbExp=2; IntAct=EBI-960730, EBI-78615; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Widely expressed at low levels. In bone marrow, expression is restricted to osteoprogenitor cells adjacent to mature osteoblasts. PTM: Phosphorylated on serine and tyrosine residues. SIMILARITY: Belongs to the SNF2/RAD54 helicase family. SIMILARITY: Contains 2 chromo domains. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain. SEQUENCE CAUTION: Sequence=AAF24170.1; Type=Erroneous translation; Note=Wrong choice of frame; Sequence=BAB14112.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q3L8U1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.