Human Gene LAPTM4B (ENST00000445593.6) Description and Page Index
  Description: P08183:ABCB1; NbExp=2; IntAct=EBI-3267258, EBI-1057359; P27986:PIK3R1; NbExp=2; IntAct=EBI-3267286, EBI-79464; (from UniProt Q86VI4)
Gencode Transcript: ENST00000445593.6
Gencode Gene: ENSG00000104341.17
Transcript (Including UTRs)
   Position: hg38 chr8:97,775,057-97,853,013 Size: 77,957 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr8:97,775,737-97,851,474 Size: 75,738 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:97,775,057-97,853,013)mRNA (may differ from genome)Protein (317 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtPubMedStanford SOURCE
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: LAP4B_HUMAN
DESCRIPTION: RecName: Full=Lysosomal-associated transmembrane protein 4B; AltName: Full=Lysosome-associated transmembrane protein 4-beta;
INTERACTION: P08183:ABCB1; NbExp=2; IntAct=EBI-3267258, EBI-1057359; P27986:PIK3R1; NbExp=2; IntAct=EBI-3267286, EBI-79464;
SUBCELLULAR LOCATION: Endomembrane system; Multi-pass membrane protein.
SIMILARITY: Belongs to the LAPTM4/LAPTM5 transporter family.
SEQUENCE CAUTION: Sequence=CAB66876.2; Type=Erroneous initiation;

-  MalaCards Disease Associations
  MalaCards Gene Search: LAPTM4B
Diseases sorted by gene-association score: hepatocellular carcinoma (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 63.85 RPKM in Heart - Atrial Appendage
Total median expression: 986.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -235.20680-0.346 Picture PostScript Text
3' UTR -407.001539-0.264 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004687 - LAPTM4/5
IPR018401 - Lysosomal-assoc_TM_prot4B

Pfam Domains:
PF03821 - Golgi 4-transmembrane spanning transporter

ModBase Predicted Comparative 3D Structure on Q86VI4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0097001 ceramide binding
GO:1902936 phosphatidylinositol bisphosphate binding

Biological Process:
GO:0007032 endosome organization
GO:0032509 endosome transport via multivesicular body sorting pathway
GO:0032911 negative regulation of transforming growth factor beta1 production
GO:0097213 regulation of lysosomal membrane permeability
GO:1905166 negative regulation of lysosomal protein catabolic process
GO:1905671 regulation of lysosome organization

Cellular Component:
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031902 late endosome membrane
GO:0032585 multivesicular body membrane
GO:0042995 cell projection
GO:0097487 multivesicular body, internal vesicle


-  Descriptions from all associated GenBank mRNAs
  BC038117 - Homo sapiens lysosomal protein transmembrane 4 beta, mRNA (cDNA clone MGC:43257 IMAGE:5264567), complete cds.
AY057051 - Homo sapiens lysosomal associated transmembrane protein 4 beta, variant 1 (LAPTM4B) mRNA, complete cds.
AY261384 - Homo sapiens lysosome-associated transmembrane protein 4 beta (LAPTM4B) mRNA, LAPTM4B-2 allele, complete cds.
LF385034 - JP 2014500723-A/192537: Polycomb-Associated Non-Coding RNAs.
MA620611 - JP 2018138019-A/192537: Polycomb-Associated Non-Coding RNAs.
AF527412 - Homo sapiens lysosomal associated transmembrane protein 4 beta variant 2 (LAPTM4B) mRNA, complete cds.
BC031021 - Homo sapiens lysosomal protein transmembrane 4 beta, mRNA (cDNA clone MGC:32802 IMAGE:4690368), complete cds.
AK075326 - Homo sapiens cDNA PSEC0001 fis, clone NT2RM1000066, moderately similar to Lysosomal-associated transmembrane protein 4 beta.
BC014129 - Homo sapiens lysosomal protein transmembrane 4 beta, mRNA (cDNA clone MGC:20748 IMAGE:4581284), complete cds.
AL136942 - Homo sapiens mRNA; cDNA DKFZp586E1124 (from clone DKFZp586E1124).
AK311377 - Homo sapiens cDNA, FLJ18419.
AX810698 - Sequence 22 from Patent EP1333092.
AJ276485 - Homo sapiens mRNA for putative integral membrane transporter protein (LC27 gene).
AB528832 - Synthetic construct DNA, clone: pF1KE0455, Homo sapiens LAPTM4B gene for lysosomal protein transmembrane 4 beta, without stop codon, in Flexi system.
AM392726 - Synthetic construct Homo sapiens clone IMAGE:100002324 for hypothetical protein (LAPTM4B gene).
AM393691 - Synthetic construct Homo sapiens clone IMAGE:100002322 for hypothetical protein (LAPTM4B gene).
AF317417 - Homo sapiens lysosomal-associated transmembrane protein 4 beta (LAPTM4beta) mRNA, complete cds.
KJ902815 - Synthetic construct Homo sapiens clone ccsbBroadEn_12209 LAPTM4B gene, encodes complete protein.
JD292536 - Sequence 273560 from Patent EP1572962.
JD155878 - Sequence 136902 from Patent EP1572962.
JD366269 - Sequence 347293 from Patent EP1572962.
JD366467 - Sequence 347491 from Patent EP1572962.
JD324803 - Sequence 305827 from Patent EP1572962.
JD324804 - Sequence 305828 from Patent EP1572962.
JD217310 - Sequence 198334 from Patent EP1572962.
JD149162 - Sequence 130186 from Patent EP1572962.
JD026902 - Sequence 7926 from Patent EP1572962.
LF336121 - JP 2014500723-A/143624: Polycomb-Associated Non-Coding RNAs.
MA571698 - JP 2018138019-A/143624: Polycomb-Associated Non-Coding RNAs.
JD028147 - Sequence 9171 from Patent EP1572962.
JD071327 - Sequence 52351 from Patent EP1572962.
LF336122 - JP 2014500723-A/143625: Polycomb-Associated Non-Coding RNAs.
MA571699 - JP 2018138019-A/143625: Polycomb-Associated Non-Coding RNAs.
JD327855 - Sequence 308879 from Patent EP1572962.
JD456075 - Sequence 437099 from Patent EP1572962.
JD456076 - Sequence 437100 from Patent EP1572962.
JD299741 - Sequence 280765 from Patent EP1572962.
JD025391 - Sequence 6415 from Patent EP1572962.
JD349656 - Sequence 330680 from Patent EP1572962.
JD029610 - Sequence 10634 from Patent EP1572962.
JD304290 - Sequence 285314 from Patent EP1572962.
JD233817 - Sequence 214841 from Patent EP1572962.
JD320312 - Sequence 301336 from Patent EP1572962.
JD274099 - Sequence 255123 from Patent EP1572962.
JD269060 - Sequence 250084 from Patent EP1572962.
JD392593 - Sequence 373617 from Patent EP1572962.
JD337153 - Sequence 318177 from Patent EP1572962.
JD433716 - Sequence 414740 from Patent EP1572962.
JD094036 - Sequence 75060 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04142 - Lysosome

-  Other Names for This Gene
  Alternate Gene Symbols: BC038117, LAP4B_HUMAN, PSEC0001, Q3ZCV5, Q7L909, Q86VH8, Q86VI4, Q9H060, uc064ovk.1
UCSC ID: uc064ovk.1
RefSeq Accession: NM_018407
Protein: Q86VI4 (aka LAP4B_HUMAN)
CCDS: CCDS6275.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.