Human Gene NOSTRIN (ENST00000445023.6) Description and Page Index
Description: Homo sapiens nitric oxide synthase trafficking (NOSTRIN), transcript variant 1, mRNA. (from RefSeq NM_052946) RefSeq Summary (NM_052946): Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]. Gencode Transcript: ENST00000445023.6 Gencode Gene: ENSG00000163072.15 Transcript (Including UTRs) Position: hg38 chr2:168,802,597-168,865,054 Size: 62,458 Total Exon Count: 15 Strand: + Coding Region Position: hg38 chr2:168,828,195-168,864,970 Size: 36,776 Coding Exon Count: 13
ID:NOSTN_HUMAN DESCRIPTION: RecName: Full=Nostrin; AltName: Full=BM247 homolog; AltName: Full=Nitric oxide synthase traffic inducer; AltName: Full=Nitric oxide synthase trafficker; AltName: Full=eNOS-trafficking inducer; FUNCTION: Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. SUBUNIT: Homotrimer. Interacts with DAB2 (By similarity). Interacts with NOS3, DNM2, WASL and CAV1. INTERACTION: P29474:NOS3; NbExp=7; IntAct=EBI-1391643, EBI-1391623; SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Note=Enriched in selected actin structures. TISSUE SPECIFICITY: Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over- expressed in placenta from women with pre-eclampsia (at protein level). DOMAIN: The SH3 domain mediates interaction with NOS3, DNM2 and WASL. DOMAIN: The FCH domain is necessary for membrane targeting. SIMILARITY: Contains 1 FCH domain. SIMILARITY: Contains 1 SH3 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IVI9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.