Human Gene CDH17 (ENST00000441892.6) Description and Page Index
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt E7EN24)
RefSeq Summary (NM_004063): This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009].
Gencode Transcript: ENST00000441892.6
Gencode Gene: ENSG00000079112.10
Transcript (Including UTRs)
   Position: hg38 chr8:94,127,872-94,208,555 Size: 80,684 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg38 chr8:94,128,240-94,194,685 Size: 66,446 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr8:94,127,872-94,208,555)mRNA (may differ from genome)Protein (580 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Cadherin-17;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: CDH17
Diseases sorted by gene-association score: gastric adenocarcinoma (4), hypotrichosis, congenital, with juvenile macular dystrophy (3), stomach cancer (2), van maldergem syndrome (2), hepatocellular carcinoma (2), deafness, autosomal recessive 23 (2), epithelial predominant wilms' tumor (2), deafness, autosomal recessive 12 (2), cleft lip/palate-ectodermal dysplasia syndrome (1), epileptic encephalopathy, early infantile, 9 (1), subcorneal pustular dermatosis (1), microcystic meningioma (1), usher syndrome, type 1b (1), hennekam syndrome (1), infiltrative basal cell carcinoma (1), gastric cancer, somatic (1), spinal canal and spinal cord meningioma (1), spinal meningioma (1), spindle cell synovial sarcoma (1), parotid gland cancer (1), cystitis cystica (1), cervix small cell carcinoma (1), appendix adenocarcinoma (1), breast papillary carcinoma (1), popliteal pterygium syndrome 1 (1), usher syndrome, type 2c (1), breast metaplastic carcinoma (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 119.41 RPKM in Colon - Transverse
Total median expression: 215.32 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.5093-0.145 Picture PostScript Text
3' UTR -95.00368-0.258 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002126 - Cadherin
IPR015919 - Cadherin-like
IPR020894 - Cadherin_CS

Pfam Domains:
PF00028 - Cadherin domain

ModBase Predicted Comparative 3D Structure on E7EN24
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding

Biological Process:
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component:
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction

-  Descriptions from all associated GenBank mRNAs
  AK130441 - Homo sapiens cDNA FLJ26931 fis, clone RCT06175, highly similar to Homo sapiens cadherin 17, LI cadherin (liver-intestine) (CDH17).
X83228 - H.sapiens mRNA for LI-cadherin.
U07969 - Human intestinal peptide-associated transporter HPT-1 mRNA, complete cds.
JD342408 - Sequence 323432 from Patent EP1572962.
AK301001 - Homo sapiens cDNA FLJ53459 complete cds, highly similar to Cadherin-17 precursor.
JD331112 - Sequence 312136 from Patent EP1572962.
JD237800 - Sequence 218824 from Patent EP1572962.
JD072511 - Sequence 53535 from Patent EP1572962.
JD555353 - Sequence 536377 from Patent EP1572962.
JD163898 - Sequence 144922 from Patent EP1572962.
JD072933 - Sequence 53957 from Patent EP1572962.
JD255996 - Sequence 237020 from Patent EP1572962.
JD255995 - Sequence 237019 from Patent EP1572962.
JD489269 - Sequence 470293 from Patent EP1572962.
JD321972 - Sequence 302996 from Patent EP1572962.
AK300638 - Homo sapiens cDNA FLJ57006 complete cds, highly similar to Cadherin-17 precursor.
JD362719 - Sequence 343743 from Patent EP1572962.
JD450423 - Sequence 431447 from Patent EP1572962.
BC112013 - Homo sapiens cadherin 17, LI cadherin (liver-intestine), mRNA (cDNA clone MGC:138218 IMAGE:8327481), complete cds.
BC113464 - Homo sapiens cadherin 17, LI cadherin (liver-intestine), mRNA (cDNA clone MGC:142024 IMAGE:8322516), complete cds.
AK312873 - Homo sapiens cDNA, FLJ93317, highly similar to Homo sapiens cadherin 17, LI cadherin (liver-intestine) (CDH17), mRNA.
HQ258682 - Synthetic construct Homo sapiens clone IMAGE:100072712 cadherin 17, LI cadherin (liver-intestine) (CDH17), transcript variant 2 (CDH17) gene, encodes complete protein.
KJ896583 - Synthetic construct Homo sapiens clone ccsbBroadEn_05977 CDH17 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: AK301001, E7EN24, E7EN24_HUMAN, uc011lgo.1, uc011lgo.2
UCSC ID: uc011lgo.2
RefSeq Accession: NM_004063
Protein: E7EN24

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.