Human Gene AGBL1 (ENST00000441037.7) Description and Page Index
Description: Homo sapiens ATP/GTP binding protein like 1 (AGBL1), mRNA. (from RefSeq NM_152336) RefSeq Summary (NM_152336): Polyglutamylation is a reversible posttranslational modification catalyzed by polyglutamylases that results in the addition of glutamate side chains on the modified protein. This gene encodes a glutamate decarboxylase that catalyzes the deglutamylation of polyglutamylated proteins. Mutations in this gene result in dominant late-onset Fuchs corneal dystrophy. [provided by RefSeq, Nov 2013]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2158800, SAMN03465409 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## Gencode Transcript: ENST00000441037.7 Gencode Gene: ENSG00000273540.4 Transcript (Including UTRs) Position: hg38 chr15:86,079,973-87,029,052 Size: 949,080 Total Exon Count: 25 Strand: + Coding Region Position: hg38 chr15:86,079,973-87,028,840 Size: 948,868 Coding Exon Count: 25
ID:CBPC4_HUMAN DESCRIPTION: RecName: Full=Cytosolic carboxypeptidase 4; EC=3.4.17.-; AltName: Full=ATP/GTP-binding protein-like 1; FUNCTION: Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5 (By similarity). COFACTOR: Binds 1 zinc ion per subunit (By similarity). SUBUNIT: Interacts with MYLK (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytosol (By similarity). SIMILARITY: Belongs to the peptidase M14 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96MI9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.