Human Gene BRF1 (ENST00000440513.7) Description and Page Index
Description: Homo sapiens BRF1 RNA polymerase III transcription initiation factor subunit (BRF1), transcript variant 4, mRNA. (from RefSeq NM_001242786) RefSeq Summary (NM_001242786): This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011]. Gencode Transcript: ENST00000440513.7 Gencode Gene: ENSG00000185024.17 Transcript (Including UTRs) Position: hg38 chr14:105,210,367-105,315,589 Size: 105,223 Total Exon Count: 18 Strand: - Coding Region Position: hg38 chr14:105,210,551-105,272,814 Size: 62,264 Coding Exon Count: 16
ID:TF3B_HUMAN DESCRIPTION: RecName: Full=Transcription factor IIIB 90 kDa subunit; Short=TFIIIB90; Short=hTFIIIB90; AltName: Full=B-related factor 1; Short=BRF-1; Short=hBRF; AltName: Full=TAF3B2; AltName: Full=TATA box-binding protein-associated factor, RNA polymerase III, subunit 2; FUNCTION: General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. SUBUNIT: TFIIIB comprises at least the TATA-binding protein (TBP) and the B-related factor 1 (BRF1/TFIIIB90). Interacts with BDP1. SUBCELLULAR LOCATION: Nucleus (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the TFIIB family. SIMILARITY: Contains 1 TFIIB-type zinc finger. SEQUENCE CAUTION: Sequence=AAC50170.1; Type=Frameshift; Positions=344, 405;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92994
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
R-HSA-83723 Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex R-HSA-83790 Binding of TFIIIB to TFIIC: Type 2 Promoter Complex R-HSA-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex R-HSA-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex R-HSA-112055 RNA Polymerase III Abortive Initiation At Type 1 Open Promoters R-HSA-112153 RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters R-HSA-76060 RNA Polymerase III Promoter Opening at Type 1 Promoters R-HSA-112149 RNA Polymerase III Abortive Initiation At Type 2 Open Promoters R-HSA-112155 RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters R-HSA-112150 RNA Polymerase III Promoter Opening at Type 2 Promoters R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation R-HSA-76046 RNA Polymerase III Transcription Initiation R-HSA-74158 RNA Polymerase III Transcription R-HSA-74160 Gene expression (Transcription)