Human Gene RANBP3 (ENST00000439268.6) Description and Page Index
Description: Homo sapiens RAN binding protein 3 (RANBP3), transcript variant RANBP3-a, mRNA. (from RefSeq NM_003624) RefSeq Summary (NM_003624): This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000439268.6 Gencode Gene: ENSG00000031823.14 Transcript (Including UTRs) Position: hg38 chr19:5,916,139-5,978,108 Size: 61,970 Total Exon Count: 17 Strand: - Coding Region Position: hg38 chr19:5,917,610-5,978,082 Size: 60,473 Coding Exon Count: 17
ID:RANB3_HUMAN DESCRIPTION: RecName: Full=Ran-binding protein 3; Short=RanBP3; FUNCTION: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF- beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. SUBUNIT: Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1. Interacts (via its C-terminal R domain) with SMAD2 (dephosphorylated form via its MH1 and MH2 domains); the interaction results in the nuclear export of SMAD2 and termination of the TGF-beta signaling. Interacts (via its C-terminal R domain) with SMAD3 (dephosphorylated form via its MH1 domain); the interaction results in the nuclear export of SMAD3 and termination of the TGF-beta signaling. INTERACTION: P18754:RCC1; NbExp=2; IntAct=EBI-992681, EBI-992720; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Widely expressed with high levels in testis and heart. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 RanBD1 domain. SEQUENCE CAUTION: Sequence=AAH04349.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=CAB43293.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H6Z4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.