Human Gene IKZF3 (ENST00000439016.2) Description and Page Index
Description: Homo sapiens IKAROS family zinc finger 3 (IKZF3), transcript variant 5, mRNA. (from RefSeq NM_183231) RefSeq Summary (NM_183231): This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]. Gencode Transcript: ENST00000439016.2 Gencode Gene: ENSG00000161405.17 Transcript (Including UTRs) Position: hg38 chr17:39,765,790-39,864,127 Size: 98,338 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr17:39,765,790-39,864,126 Size: 98,337 Coding Exon Count: 6
ID:IKZF3_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein Aiolos; AltName: Full=Ikaros family zinc finger protein 3; FUNCTION: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner. SUBUNIT: Homodimer, and heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5. Interacts with IKZF1. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform Bcl-X(L); this interaction blocks the anti- apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A. INTERACTION: Q9BZS1:FOXP3; NbExp=2; IntAct=EBI-747204, EBI-983719; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. TISSUE SPECIFICITY: Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus. INDUCTION: Up-regulated by TGFB1 and 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) in activated AHR T-cells. PTM: Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells. SIMILARITY: Belongs to the Ikaros C2H2-type zinc-finger protein family. SIMILARITY: Contains 6 C2H2-type zinc fingers.
ModBase Predicted Comparative 3D Structure on Q9UKT9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0042802 identical protein binding GO:0042803 protein homodimerization activity GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0046872 metal ion binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0007498 mesoderm development GO:0030888 regulation of B cell proliferation GO:0042113 B cell activation GO:0042981 regulation of apoptotic process GO:0045577 regulation of B cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter