Human Gene PLEKHB2 (ENST00000438882.6) Description and Page Index
  Description: Homo sapiens pleckstrin homology domain containing B2 (PLEKHB2), transcript variant 8, mRNA. (from RefSeq NM_001267066)
Gencode Transcript: ENST00000438882.6
Gencode Gene: ENSG00000115762.16
Transcript (Including UTRs)
   Position: hg38 chr2:131,105,336-131,147,602 Size: 42,267 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr2:131,120,942-131,146,750 Size: 25,809 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:131,105,336-131,147,602)mRNA (may differ from genome)Protein (178 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtOMIMPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Pleckstrin homology domain-containing family B member 2; Short=PH domain-containing family B member 2; AltName: Full=Evectin-2;
FUNCTION: Involved in retrograde transport of recycling endosomes.
SUBCELLULAR LOCATION: Recycling endosome membrane; Peripheral membrane protein. Note=Specifically detected in tubulovesicular structures, and colocalizes with TFNR.
DOMAIN: The PH domain specifically binds phosphatidylserine, which is enriched in recycling endosome membranes, it doesn't recognize PIPs.
SIMILARITY: Contains 1 PH domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: PLEKHB2
Diseases sorted by gene-association score: exudative vitreoretinopathy (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.74 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 854.82 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -28.4071-0.400 Picture PostScript Text
3' UTR -264.50852-0.310 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology

Pfam Domains:
PF00169 - PH domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q96CS7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding

Biological Process:
GO:0045595 regulation of cell differentiation

Cellular Component:
GO:0005768 endosome
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0055038 recycling endosome membrane

-  Descriptions from all associated GenBank mRNAs
  LP895394 - Sequence 258 from Patent EP3253886.
BC001428 - Homo sapiens pleckstrin homology domain containing, family B (evectins) member 2, mRNA (cDNA clone MGC:1005 IMAGE:3139876), complete cds.
DQ895139 - Synthetic construct Homo sapiens clone IMAGE:100009599; FLH181721.01L; RZPDo839G06135D pleckstrin homology domain containing, family B (evectins) member 2 (PLEKHB2) gene, encodes complete protein.
DQ891953 - Synthetic construct clone IMAGE:100004583; FLH181725.01X; RZPDo839G06136D pleckstrin homology domain containing, family B (evectins) member 2 (PLEKHB2) gene, encodes complete protein.
AK126289 - Homo sapiens cDNA FLJ44309 fis, clone TRACH2025535, highly similar to Mus musculus evectin-2 (Evt2).
AK302770 - Homo sapiens cDNA FLJ54089 complete cds, highly similar to Pleckstrin homology domain-containing family B member 2.
AK293880 - Homo sapiens cDNA FLJ52534 complete cds, highly similar to Pleckstrin homology domain-containing family B member 2.
AK000790 - Homo sapiens cDNA FLJ20783 fis, clone COL03108.
AK223338 - Homo sapiens mRNA for pleckstrin homology domain containing, family B (evectins) member 2 variant, clone: TST02947.
AK296008 - Homo sapiens cDNA FLJ59903 complete cds, highly similar to Pleckstrin homology domain-containing familyB member 2.
BC050695 - Homo sapiens pleckstrin homology domain containing, family B (evectins) member 2, mRNA (cDNA clone MGC:60279 IMAGE:6162960), complete cds.
BC013991 - Homo sapiens pleckstrin homology domain containing, family B (evectins) member 2, mRNA (cDNA clone MGC:19978 IMAGE:3639839), complete cds.
AK123710 - Homo sapiens cDNA FLJ41716 fis, clone HLUNG2012546, highly similar to Pleckstrin homology domain-containing family B member 2.
AK093730 - Homo sapiens cDNA FLJ36411 fis, clone THYMU2010699, highly similar to Mus musculus evectin-2 (Evt2) mRNA.
AX748281 - Sequence 1806 from Patent EP1308459.
CU680728 - Synthetic construct Homo sapiens gateway clone IMAGE:100023322 5' read PLEKHB2 mRNA.
KJ894117 - Synthetic construct Homo sapiens clone ccsbBroadEn_03511 PLEKHB2 gene, encodes complete protein.
DQ581595 - Homo sapiens piRNA piR-49707, complete sequence.
DQ572159 - Homo sapiens piRNA piR-40271, complete sequence.
DQ572774 - Homo sapiens piRNA piR-40886, complete sequence.
JD501188 - Sequence 482212 from Patent EP1572962.
JD485469 - Sequence 466493 from Patent EP1572962.
JD484396 - Sequence 465420 from Patent EP1572962.
JD137176 - Sequence 118200 from Patent EP1572962.
DQ584420 - Homo sapiens piRNA piR-51532, complete sequence.
JD566529 - Sequence 547553 from Patent EP1572962.
JD040765 - Sequence 21789 from Patent EP1572962.
JD241660 - Sequence 222684 from Patent EP1572962.
JD078335 - Sequence 59359 from Patent EP1572962.
JD143266 - Sequence 124290 from Patent EP1572962.
JD420329 - Sequence 401353 from Patent EP1572962.
JD295593 - Sequence 276617 from Patent EP1572962.
DQ589844 - Homo sapiens piRNA piR-56956, complete sequence.
DQ589845 - Homo sapiens piRNA piR-56957, complete sequence.
JD533518 - Sequence 514542 from Patent EP1572962.
JD101769 - Sequence 82793 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: EVT2, NM_001267066, PKHB2_HUMAN, Q53FF1, Q53TH7, Q86W37, Q96CS7, Q9BV75, Q9NWK1, uc010zap.1, uc010zap.2, uc010zap.3
UCSC ID: uc010zap.3
RefSeq Accession: NM_001267066
Protein: Q96CS7 (aka PKHB2_HUMAN)
CCDS: CCDS58729.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.