Human Gene ELF5 (ENST00000429939.6) Description and Page Index
Description: Homo sapiens E74 like ETS transcription factor 5 (ELF5), transcript variant 3, mRNA. (from RefSeq NM_001243080) RefSeq Summary (NM_001243080): The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]. Gencode Transcript: ENST00000429939.6 Gencode Gene: ENSG00000135374.9 Transcript (Including UTRs) Position: hg38 chr11:34,480,197-34,513,805 Size: 33,609 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr11:34,480,218-34,505,749 Size: 25,532 Coding Exon Count: 4
ID:ELF5_HUMAN DESCRIPTION: RecName: Full=ETS-related transcription factor Elf-5; AltName: Full=E74-like factor 5; AltName: Full=Epithelium-restricted ESE-1-related Ets factor; AltName: Full=Epithelium-specific Ets transcription factor 2; Short=ESE-2; FUNCTION: Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. FUNCTION: Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression. DOMAIN: The PNT domain acts as a transcriptional activator (By similarity). SIMILARITY: Belongs to the ETS family. SIMILARITY: Contains 1 ETS DNA-binding domain. SIMILARITY: Contains 1 PNT (pointed) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UKW6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0001712 ectodermal cell fate commitment GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0007398 ectoderm development GO:0008283 cell proliferation GO:0030154 cell differentiation GO:0035019 somatic stem cell population maintenance GO:0045596 negative regulation of cell differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0060644 mammary gland epithelial cell differentiation