Human Gene STMN1 (ENST00000426559.6) Description and Page Index
  Description: Homo sapiens stathmin 1 (STMN1), transcript variant 4, mRNA. (from RefSeq NM_001145454)
RefSeq Summary (NM_001145454): This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].
Gencode Transcript: ENST00000426559.6
Gencode Gene: ENSG00000117632.23
Transcript (Including UTRs)
   Position: hg38 chr1:25,885,440-25,906,466 Size: 21,027 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr1:25,885,723-25,904,676 Size: 18,954 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:25,885,440-25,906,466)mRNA (may differ from genome)Protein (174 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: STMN1_HUMAN
DESCRIPTION: RecName: Full=Stathmin; AltName: Full=Leukemia-associated phosphoprotein p18; AltName: Full=Metablastin; AltName: Full=Oncoprotein 18; Short=Op18; AltName: Full=Phosphoprotein p19; Short=pp19; AltName: Full=Prosolin; AltName: Full=Protein Pr22; AltName: Full=pp17;
FUNCTION: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
SUBUNIT: Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
TISSUE SPECIFICITY: Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.
INDUCTION: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).
PTM: Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.
SIMILARITY: Belongs to the stathmin family.

-  MalaCards Disease Associations
  MalaCards Gene Search: STMN1
Diseases sorted by gene-association score: pancreatic intraductal papillary-mucinous adenoma (16), acute leukemia (13), agoraphobia (9), humeroradial synostosis (9), ovarian clear cell adenocarcinoma (8), triple-receptor negative breast cancer (6), renpenning syndrome (5), shprintzen-goldberg syndrome (4), partington syndrome (4), medulloblastoma (2), breast cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 123.01 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 1309.33 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -41.90140-0.299 Picture PostScript Text
3' UTR -80.40283-0.284 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000956 - Stathmin_fam

Pfam Domains:
PF00836 - Stathmin family

ModBase Predicted Comparative 3D Structure on P16949
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0015631 tubulin binding

Biological Process:
GO:0000281 mitotic cytokinesis
GO:0007019 microtubule depolymerization
GO:0007052 mitotic spindle organization
GO:0007165 signal transduction
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007409 axonogenesis
GO:0007420 brain development
GO:0009615 response to virus
GO:0030154 cell differentiation
GO:0031110 regulation of microtubule polymerization or depolymerization
GO:0031115 negative regulation of microtubule polymerization
GO:0031175 neuron projection development
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0051272 positive regulation of cellular component movement
GO:0051497 negative regulation of stress fiber assembly
GO:0061436 establishment of skin barrier
GO:0070495 negative regulation of thrombin-activated receptor signaling pathway
GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity

Cellular Component:
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0016020 membrane
GO:0043005 neuron projection
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK056768 - Homo sapiens cDNA FLJ32206 fis, clone PLACE6003109.
BC028398 - Homo sapiens chromosome 1 open reading frame 215, mRNA (cDNA clone IMAGE:4801127).
BC114443 - Homo sapiens stathmin 1/oncoprotein 18, mRNA (cDNA clone MGC:138869 IMAGE:40083863), complete cds.
BC114502 - Homo sapiens stathmin 1/oncoprotein 18, mRNA (cDNA clone MGC:138870 IMAGE:40083868), complete cds.
JD271928 - Sequence 252952 from Patent EP1572962.
AK303692 - Homo sapiens cDNA FLJ57769 complete cds, highly similar to Stathmin.
JD459953 - Sequence 440977 from Patent EP1572962.
JD273671 - Sequence 254695 from Patent EP1572962.
JD239549 - Sequence 220573 from Patent EP1572962.
JD486036 - Sequence 467060 from Patent EP1572962.
JD043820 - Sequence 24844 from Patent EP1572962.
HM005502 - Homo sapiens clone HTL-T-189 testicular tissue protein Li 189 mRNA, complete cds.
JD048571 - Sequence 29595 from Patent EP1572962.
JD242295 - Sequence 223319 from Patent EP1572962.
JD323874 - Sequence 304898 from Patent EP1572962.
JD403974 - Sequence 384998 from Patent EP1572962.
JD555778 - Sequence 536802 from Patent EP1572962.
JD247145 - Sequence 228169 from Patent EP1572962.
JD203896 - Sequence 184920 from Patent EP1572962.
BC040585 - Homo sapiens cDNA clone IMAGE:5269067, **** WARNING: chimeric clone ****.
J04991 - Human p18 protein mRNA, complete cds.
X53305 - H.sapiens mRNA for stathmin.
Z11566 - H.sapiens mRNA for Pr22 protein.
AK054594 - Homo sapiens cDNA FLJ30032 fis, clone 3NB692001366, highly similar to STATHMIN.
BC023313 - Homo sapiens stathmin 1/oncoprotein 18, mRNA (cDNA clone IMAGE:4939590), with apparent retained intron.
AB209282 - Homo sapiens mRNA for stathmin 1 variant protein.
BX647885 - Homo sapiens mRNA; cDNA DKFZp686C18102 (from clone DKFZp686C18102).
BC014353 - Homo sapiens stathmin 1/oncoprotein 18, mRNA (cDNA clone MGC:24199 IMAGE:3683516), complete cds.
BC082228 - Homo sapiens stathmin 1/oncoprotein 18, mRNA (cDNA clone MGC:99593 IMAGE:2822803), complete cds.
AB451319 - Homo sapiens STMN1 mRNA for stathmin 1, complete cds, clone: FLJ08188AAAN.
KJ905819 - Synthetic construct Homo sapiens clone ccsbBroadEn_15489 STMN1 gene, encodes complete protein.
AK311801 - Homo sapiens cDNA, FLJ92062, Homo sapiens stathmin 1/oncoprotein 18 (STMN1), mRNA.
CU687358 - Synthetic construct Homo sapiens gateway clone IMAGE:100023060 5' read STMN1 mRNA.
KJ897121 - Synthetic construct Homo sapiens clone ccsbBroadEn_06515 STMN1 gene, encodes complete protein.
AB451448 - Homo sapiens STMN1 mRNA for stathmin 1, partial cds, clone: FLJ08188AAAF.
AB464250 - Synthetic construct DNA, clone: pF1KB8233, Homo sapiens STMN1 gene for stathmin 1/oncoprotein 18, without stop codon, in Flexi system.
AM392854 - Synthetic construct Homo sapiens clone IMAGE:100002031 for hypothetical protein (STMN1 gene).
LF378811 - JP 2014500723-A/186314: Polycomb-Associated Non-Coding RNAs.
MA614388 - JP 2018138019-A/186314: Polycomb-Associated Non-Coding RNAs.
D28428 - Homo sapiens mRNA for stathmin, 5'UTR region.
DQ585108 - Homo sapiens piRNA piR-52220, complete sequence.
HZ409179 - JP 2015528002-A/1776: CHIRAL CONTROL.
HZ460751 - WO 2015190584-A/248: Kit or device and method for detecting prostate cancer.
HZ462269 - WO 2015190591-A/424: Kit and method for detecting breast cancer.
HZ464481 - WO 2015194615-A/299: Kit or device and method for detecting hepatic cancer.
LG052513 - KR 1020150036642-A/1779: CHIRAL CONTROL.
LY498382 - KR 1020170018411-A/299: LIVER CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD.
LY499272 - KR 1020170018412-A/424: BREAST CANCER DETECTION KIT OR DEVICE, AND METHOD FOR DETECTING BREAST CANCER.
LY500624 - KR 1020170016490-A/248: PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD.
LZ238643 - WO 2017171048-A/304: Kit, device and method for detecting early pancreatic cancer or precancerous lesion of pancreas.
MS869543 - Sequence 248 from Patent EP3156483.
MS880587 - Sequence 424 from Patent EP3156498.
HW798928 - WO 2014192907-A/34: Method for detecting miRNA used for differentiating disorders causing motor neuropathy.
HZ083302 - JP 2015513906-A/659: Stem Cell Microparticles.
HZ437083 - JP 2015529450-A/659: Stem Cell Microparticles.
HZ460565 - WO 2015190584-A/62: Kit or device and method for detecting prostate cancer.
HZ461991 - WO 2015190591-A/146: Kit and method for detecting breast cancer.
HZ464258 - WO 2015194615-A/76: Kit or device and method for detecting hepatic cancer.
HZ480412 - JP 2015535430-A/918: TERMINALLY MODIFIED RNA.
HZ790343 - JP 2016504050-A/2088: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
JC172287 - Sequence 659 from Patent WO2013150303.
JC513075 - Sequence 3328 from Patent WO2014113089.
JC573098 - Sequence 659 from Patent WO2014125276.
JC582786 - Sequence 659 from Patent WO2014125277.
JE954482 - Sequence 659 from Patent WO2015052526.
JE956235 - Sequence 659 from Patent WO2015052527.
LF137987 - JP 2016507550-A/659: Method of Producing Microparticles.
LF160085 - JP 2016513950-A/151: Oligomers with improved off-target profile.
LF162952 - JP 2016513095-A/659: Stem Cell Microparticles and miRNA.
LF953704 - JP 2016534103-A/659: Stem Cell Microparticles and miRNA.
LG006049 - KR 1020150004822-A/659: STEM CELL MICROPARTICLES.
LG053745 - KR 1020150059168-A/659: STEM CELL MICROPARTICLES.
LG240984 - KR 1020160035087-A/659: STEM CELL MICROPARTICLES AND MIRNA.
LP896702 - Sequence 1566 from Patent EP3253886.
LQ070663 - Sequence 987 from Patent EP2964234.
LQ724413 - Sequence 46 from Patent WO2018096084.
LV471069 - JP 2016534036-A/659: Stem Cell Microparticles and miRNA.
LY498159 - KR 1020170018411-A/76: LIVER CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD.
LY498994 - KR 1020170018412-A/146: BREAST CANCER DETECTION KIT OR DEVICE, AND METHOD FOR DETECTING BREAST CANCER.
LY500438 - KR 1020170016490-A/62: PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD.
LZ238392 - WO 2017171048-A/53: Kit, device and method for detecting early pancreatic cancer or precancerous lesion of pancreas.
MA405387 - WO 2018155427-A/161: A probe with reduced false positive binding, a method to desing the probe, and the use thereof.
MA644164 - JP 2017113010-A/2088: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA732048 - JP 2017140048-A/918: TERMINALLY MODIFIED RNA.
MP014953 - Sequence 156 from Patent WO2019016252.
MS869357 - Sequence 62 from Patent EP3156483.
MS880309 - Sequence 146 from Patent EP3156498.
HZ460943 - WO 2015190584-A/440: Kit or device and method for detecting prostate cancer.
HZ462556 - WO 2015190591-A/711: Kit and method for detecting breast cancer.
HZ464694 - WO 2015194615-A/512: Kit or device and method for detecting hepatic cancer.
LY498595 - KR 1020170018411-A/512: LIVER CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD.
LY499559 - KR 1020170018412-A/711: BREAST CANCER DETECTION KIT OR DEVICE, AND METHOD FOR DETECTING BREAST CANCER.
LY500816 - KR 1020170016490-A/440: PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD.
LZ238910 - WO 2017171048-A/571: Kit, device and method for detecting early pancreatic cancer or precancerous lesion of pancreas.
MS869735 - Sequence 440 from Patent EP3156483.
MS880874 - Sequence 711 from Patent EP3156498.
MA806141 - WO 2018199275-A/401: Kit, device and method for detection of ovary tumor.
MA801217 - JP 2018183181-A/2088: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA805864 - WO 2018199275-A/124: Kit, device and method for detection of ovary tumor.
MA806418 - WO 2018199275-A/678: Kit, device and method for detection of ovary tumor.
MA822561 - WO 2019004436-A/374: Kit, device, and method for detection of lung cancer.
MA822225 - WO 2019004436-A/38: Kit, device, and method for detection of lung cancer.
MP129759 - Sequence 659 from Patent EP3470073.
MP162682 - Sequence 659 from Patent WO2019069093.
MA822894 - WO 2019004436-A/707: Kit, device, and method for detection of lung cancer.
LY616407 - KR 1020180129785-A/304: KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR.
LY616156 - KR 1020180129785-A/53: KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR.
LY616674 - KR 1020180129785-A/571: KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway

BioCarta from NCI Cancer Genome Anatomy Project
h_stathminPathway - Stathmin and breast cancer resistance to antimicrotubule agents

-  Other Names for This Gene
  Alternate Gene Symbols: A2A2D1, B2R4E7, B7Z8N4, C1orf215, D3DPJ5, LAP18, NM_001145454, OP18, P16949, STMN1_HUMAN, uc010oev.1, uc010oev.2, uc010oev.3
UCSC ID: uc010oev.3
RefSeq Accession: NM_001145454
Protein: P16949 (aka STMN1_HUMAN or STN1_HUMAN)
CCDS: CCDS44090.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.