Human Gene SLC4A7 (ENST00000425128.6) Description and Page Index
Description: solute carrier family 4 member 7 (from HGNC SLC4A7) RefSeq Summary (NM_001321106): This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU934246.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## Gencode Transcript: ENST00000425128.6 Gencode Gene: ENSG00000033867.16 Transcript (Including UTRs) Position: hg38 chr3:27,372,721-27,484,420 Size: 111,700 Total Exon Count: 28 Strand: - Coding Region Position: hg38 chr3:27,376,764-27,484,099 Size: 107,336 Coding Exon Count: 28
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.