Human Gene SLC4A7 (ENST00000425128.6) Description and Page Index
  Description: solute carrier family 4 member 7 (from HGNC SLC4A7)
RefSeq Summary (NM_001321106): This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU934246.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##
Gencode Transcript: ENST00000425128.6
Gencode Gene: ENSG00000033867.16
Transcript (Including UTRs)
   Position: hg38 chr3:27,372,721-27,484,420 Size: 111,700 Total Exon Count: 28 Strand: -
Coding Region
   Position: hg38 chr3:27,376,764-27,484,099 Size: 107,336 Coding Exon Count: 28 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:27,372,721-27,484,420)mRNA (may differ from genome)Protein (1201 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: SLC4A7
Diseases sorted by gene-association score: renal tubular acidosis (9), usher syndrome, type 3a (7), usher syndrome, type 2c (5), usher syndrome type 2 (4), usher syndrome (2), usher syndrome, type 1b (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.92 RPKM in Colon - Sigmoid
Total median expression: 219.32 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -148.30321-0.462 Picture PostScript Text
3' UTR -869.404043-0.215 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  CR627428 - Homo sapiens mRNA; cDNA DKFZp686H168 (from clone DKFZp686H168).
AF047033 - Homo sapiens sodium bicarbonate cotransporter 3 (SLC4A7) mRNA, complete cds.
AF089726 - Homo sapiens sodium bicarbonate cotransporter 2b (NBC2B) mRNA, complete cds.
JA482255 - Sequence 238 from Patent WO2011072091.
JE980547 - Sequence 238 from Patent EP2862929.
AF053755 - Homo sapiens bicarbonate transporter (BT) mRNA, complete cds.
EU499349 - Homo sapiens clone NBCn1-G solute carrier family 4 sodium bicarbonate cotransporter member 7 (SLC4A7) mRNA, complete cds, alternatively spliced.
EU934246 - Homo sapiens clone NBCn1-Ha solute carrier family 4 sodium bicarbonate cotransporter member 7 (SLC4A7) mRNA, complete cds, alternatively spliced.
EU934247 - Homo sapiens clone NBCn1-Hb solute carrier family 4 sodium bicarbonate cotransporter member 7 (SLC4A7) mRNA, complete cds, alternatively spliced.
EU934248 - Homo sapiens clone NBCn1-D solute carrier family 4 sodium bicarbonate cotransporter member 7 (SLC4A7) mRNA, complete cds, alternatively spliced.
EU934249 - Homo sapiens clone NBCn1-E solute carrier family 4 sodium bicarbonate cotransporter member 7 (SLC4A7) mRNA, complete cds, alternatively spliced.
EU934250 - Homo sapiens clone NBCn1-C solute carrier family 4 sodium bicarbonate cotransporter member 7 (SLC4A7) mRNA, complete cds, alternatively spliced.
FJ178574 - Homo sapiens solute carrier family 4 sodium bicarbonate cotransporter member 7 type 3 variant (SLC4A7) mRNA, complete cds, alternatively spliced.
FJ178575 - Homo sapiens solute carrier family 4 sodium bicarbonate cotransporter member 7 type 1 variant (SLC4A7) mRNA, complete cds, alternatively spliced.
GU354307 - Homo sapiens solute carrier family 4 sodium bicarbonate cotransporter member 7 truncated type 4 variant mRNA, complete cds, alternatively spliced.
GU354308 - Homo sapiens solute carrier family 4 sodium bicarbonate cotransporter member 7 mRNA, complete cds, alternatively spliced.
GU354310 - Homo sapiens solute carrier family 4 sodium bicarbonate cotransporter member 7 truncated type 1b variant mRNA, complete cds, alternatively spliced.
AB012130 - Homo sapiens SBC2 mRNA for sodium bicarbonate cotransporter2, complete cds.
FJ178576 - Homo sapiens solute carrier family 4 sodium bicarbonate cotransporter member 7 type 2 variant (SLC4A7) mRNA, complete cds, alternatively spliced.
GU354309 - Homo sapiens solute carrier family 4 sodium bicarbonate cotransporter member 7 truncated type 2b variant mRNA, complete cds, alternatively spliced.
BC172463 - Synthetic construct Homo sapiens clone IMAGE:100069157, MGC:199168 solute carrier family 4, sodium bicarbonate cotransporter, member 7 (SLC4A7) mRNA, encodes complete protein.
BC156213 - Synthetic construct Homo sapiens clone IMAGE:100061541, MGC:190018 solute carrier family 4, sodium bicarbonate cotransporter, member 7 (SLC4A7) mRNA, encodes complete protein.
AL833589 - Homo sapiens mRNA; cDNA DKFZp686D0264 (from clone DKFZp686D0264).
AL389947 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 2005674.
JD560147 - Sequence 541171 from Patent EP1572962.
JD082751 - Sequence 63775 from Patent EP1572962.
JD357082 - Sequence 338106 from Patent EP1572962.
JD508951 - Sequence 489975 from Patent EP1572962.
JD110589 - Sequence 91613 from Patent EP1572962.
JD089993 - Sequence 71017 from Patent EP1572962.
JD038988 - Sequence 20012 from Patent EP1572962.
JD261587 - Sequence 242611 from Patent EP1572962.
JD565006 - Sequence 546030 from Patent EP1572962.
JD202433 - Sequence 183457 from Patent EP1572962.
JD268537 - Sequence 249561 from Patent EP1572962.
JD232288 - Sequence 213312 from Patent EP1572962.
JD279795 - Sequence 260819 from Patent EP1572962.
JD314453 - Sequence 295477 from Patent EP1572962.
MF281507 - Homo sapiens miAB18_pre miRNA, complete sequence.
JD182947 - Sequence 163971 from Patent EP1572962.
MF281469 - Homo sapiens miAB18 miRNA, complete sequence.
JD043207 - Sequence 24231 from Patent EP1572962.
JD502225 - Sequence 483249 from Patent EP1572962.
JD551782 - Sequence 532806 from Patent EP1572962.
JD350671 - Sequence 331695 from Patent EP1572962.
JD240268 - Sequence 221292 from Patent EP1572962.
JD236746 - Sequence 217770 from Patent EP1572962.
JD428801 - Sequence 409825 from Patent EP1572962.
AK310865 - Homo sapiens cDNA, FLJ17907.
JD500786 - Sequence 481810 from Patent EP1572962.
JD528105 - Sequence 509129 from Patent EP1572962.
JD048800 - Sequence 29824 from Patent EP1572962.
JD521386 - Sequence 502410 from Patent EP1572962.
JD499402 - Sequence 480426 from Patent EP1572962.
JD320112 - Sequence 301136 from Patent EP1572962.
JD171330 - Sequence 152354 from Patent EP1572962.
JD258609 - Sequence 239633 from Patent EP1572962.
JD299135 - Sequence 280159 from Patent EP1572962.
JD491250 - Sequence 472274 from Patent EP1572962.
JD509767 - Sequence 490791 from Patent EP1572962.
AK309734 - Homo sapiens cDNA, FLJ99775.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A0A0MST8, JA482255, uc062hqm.1
UCSC ID: uc062hqm.1
RefSeq Accession: NM_001321106
CCDS: CCDS33721.1, CCDS82748.1, CCDS82749.1, CCDS82751.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.