Human Gene NHLRC4 (ENST00000424439.3) Description and Page Index
  Description: Homo sapiens NHL repeat containing 4 (NHLRC4), transcript variant 1, mRNA. (from RefSeq NM_001301159)
Gencode Transcript: ENST00000424439.3
Gencode Gene: ENSG00000257108.2
Transcript (Including UTRs)
   Position: hg38 chr16:567,005-569,495 Size: 2,491 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr16:568,048-568,419 Size: 372 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsRNA StructureProtein StructureOther Species
mRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:567,005-569,495)mRNA (may differ from genome)Protein (123 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsHGNCLynx
MGIneXtProtPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=NHL-repeat-containing protein 4;
SIMILARITY: Contains 2 NHL repeats.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -326.50648-0.504 Picture PostScript Text
3' UTR -557.001076-0.518 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011042 - 6-blade_b-propeller_TolB-like
IPR001258 - NHL_repeat
IPR013017 - NHL_repeat_subgr

Pfam Domains:
PF01436 - NHL repeat

ModBase Predicted Comparative 3D Structure on P0CG21
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  AK314361 - Homo sapiens cDNA, FLJ95129, highly similar to Homo sapiens phosphatidylinositol glycan, class Q (PIGQ), transcript variant 2, mRNA.
AK093527 - Homo sapiens cDNA FLJ36208 fis, clone THYMU1000428, weakly similar to ZINC-FINGER PROTEIN HT2A.
AX748186 - Sequence 1711 from Patent EP1308459.
BC048340 - Homo sapiens hypothetical protein FLJ36208, mRNA (cDNA clone IMAGE:5210125).
BC032015 - Homo sapiens hypothetical protein FLJ36208, mRNA (cDNA clone IMAGE:5170412).
BC113527 - Homo sapiens hypothetical protein FLJ36208, mRNA (cDNA clone MGC:142087 IMAGE:8322579), complete cds.
BC113529 - Homo sapiens hypothetical protein FLJ36208, mRNA (cDNA clone MGC:142089 IMAGE:8322581), complete cds.
JD141485 - Sequence 122509 from Patent EP1572962.
JD174423 - Sequence 155447 from Patent EP1572962.
JD518666 - Sequence 499690 from Patent EP1572962.
JD405690 - Sequence 386714 from Patent EP1572962.
JD218552 - Sequence 199576 from Patent EP1572962.
JD123596 - Sequence 104620 from Patent EP1572962.
JD395997 - Sequence 377021 from Patent EP1572962.
JD354241 - Sequence 335265 from Patent EP1572962.
JD095202 - Sequence 76226 from Patent EP1572962.
JD400307 - Sequence 381331 from Patent EP1572962.
JD201754 - Sequence 182778 from Patent EP1572962.
JD210192 - Sequence 191216 from Patent EP1572962.
JD105085 - Sequence 86109 from Patent EP1572962.
HQ258060 - Synthetic construct Homo sapiens clone IMAGE:100072369 NHL repeat containing 4 (NHLRC4) (C16orf11) gene, encodes complete protein.
KJ895974 - Synthetic construct Homo sapiens clone ccsbBroadEn_05368 NHLRC4 gene, encodes complete protein.
JD466660 - Sequence 447684 from Patent EP1572962.
JD431968 - Sequence 412992 from Patent EP1572962.
JD329644 - Sequence 310668 from Patent EP1572962.
JD461398 - Sequence 442422 from Patent EP1572962.
JD554812 - Sequence 535836 from Patent EP1572962.
JD403369 - Sequence 384393 from Patent EP1572962.
JD294298 - Sequence 275322 from Patent EP1572962.
JD476532 - Sequence 457556 from Patent EP1572962.
JD221080 - Sequence 202104 from Patent EP1572962.
JD209420 - Sequence 190444 from Patent EP1572962.
JD278526 - Sequence 259550 from Patent EP1572962.
JD139302 - Sequence 120326 from Patent EP1572962.
JD546170 - Sequence 527194 from Patent EP1572962.
JD221602 - Sequence 202626 from Patent EP1572962.
JD341887 - Sequence 322911 from Patent EP1572962.
JD134930 - Sequence 115954 from Patent EP1572962.
JD107211 - Sequence 88235 from Patent EP1572962.
JD474890 - Sequence 455914 from Patent EP1572962.
JD425649 - Sequence 406673 from Patent EP1572962.
JD474279 - Sequence 455303 from Patent EP1572962.
JD282892 - Sequence 263916 from Patent EP1572962.
JD477509 - Sequence 458533 from Patent EP1572962.
JD410392 - Sequence 391416 from Patent EP1572962.
JD443631 - Sequence 424655 from Patent EP1572962.
JD225471 - Sequence 206495 from Patent EP1572962.
JD499352 - Sequence 480376 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B8ZZ27, NHLC4_HUMAN, NM_001301159, P0CG21, Q8N233, Q96AX3, Q96S23, uc021szs.1, uc021szs.2, uc021szs.3, uc021szs.4
UCSC ID: uc021szs.4
RefSeq Accession: NM_001301159
Protein: P0CG21 (aka NHLC4_HUMAN)
CCDS: CCDS45366.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.