Human Gene PRDM10 (ENST00000423662.6) Description and Page Index
Description: Homo sapiens PR/SET domain 10 (PRDM10), transcript variant 3, mRNA. (from RefSeq NM_199438) RefSeq Summary (NM_199438): The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000423662.6 Gencode Gene: ENSG00000170325.14 Transcript (Including UTRs) Position: hg38 chr11:129,899,717-129,947,622 Size: 47,906 Total Exon Count: 18 Strand: - Coding Region Position: hg38 chr11:129,902,313-129,947,406 Size: 45,094 Coding Exon Count: 18
ID:PRD10_HUMAN DESCRIPTION: RecName: Full=PR domain zinc finger protein 10; AltName: Full=PR domain-containing protein 10; AltName: Full=Tristanin; FUNCTION: May be involved in transcriptional regulation (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). DOMAIN: The SET domain is degenerated, suggesting that it has lost mehtyltransferase activity. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 10 C2H2-type zinc fingers. SIMILARITY: Contains 1 SET domain. SEQUENCE CAUTION: Sequence=BAA91026.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NQV6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.