Human Gene TUBGCP2 (ENST00000417178.6) Description and Page Index
  Description: Homo sapiens tubulin gamma complex associated protein 2 (TUBGCP2), transcript variant 3, mRNA. (from RefSeq NM_001256618)
Gencode Transcript: ENST00000417178.6
Gencode Gene: ENSG00000130640.13
Transcript (Including UTRs)
   Position: hg38 chr10:133,278,630-133,309,156 Size: 30,527 Total Exon Count: 17 Strand: -
Coding Region
   Position: hg38 chr10:133,279,766-133,299,492 Size: 19,727 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:133,278,630-133,309,156)mRNA (may differ from genome)Protein (772 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGImyGene2neXtProtOMIM
PubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: GCP2_HUMAN
DESCRIPTION: RecName: Full=Gamma-tubulin complex component 2; Short=GCP-2; Short=hGCP2; AltName: Full=Gamma-ring complex protein 103 kDa; Short=h103p; Short=hGrip103; AltName: Full=Spindle pole body protein Spc97 homolog; Short=hSpc97;
FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
SUBUNIT: Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome.
TISSUE SPECIFICITY: Ubiquitously expressed.
SIMILARITY: Belongs to the TUBGCP family.
SEQUENCE CAUTION: Sequence=BC005011; Type=Frameshift; Positions=513;

-  MalaCards Disease Associations
  MalaCards Gene Search: TUBGCP2
Diseases sorted by gene-association score: cardiomyopathy, dilated, 1p (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 26.98 RPKM in Testis
Total median expression: 871.95 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -234.80574-0.409 Picture PostScript Text
3' UTR -480.801136-0.423 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007259 - Spc97_Spc98

Pfam Domains:
PF04130 - Spc97 / Spc98 family

ModBase Predicted Comparative 3D Structure on Q9BSJ2
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0043015 gamma-tubulin binding
GO:0051011 microtubule minus-end binding

Biological Process:
GO:0000226 microtubule cytoskeleton organization
GO:0007020 microtubule nucleation
GO:0031122 cytoplasmic microtubule organization
GO:0051298 centrosome duplication
GO:0051321 meiotic cell cycle
GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center
GO:0065003 macromolecular complex assembly
GO:0090307 mitotic spindle assembly

Cellular Component:
GO:0000922 spindle pole
GO:0000923 equatorial microtubule organizing center
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005881 cytoplasmic microtubule
GO:0008275 gamma-tubulin small complex
GO:0016020 membrane
GO:0005816 spindle pole body


-  Descriptions from all associated GenBank mRNAs
  AK299564 - Homo sapiens cDNA FLJ58259 complete cds, highly similar to Gamma-tubulin complex component 2.
AK297251 - Homo sapiens cDNA FLJ58511 complete cds, highly similar to Gamma-tubulin complex component 2.
BC005011 - Homo sapiens cDNA clone IMAGE:3640780, containing frame-shift errors.
AK223586 - Homo sapiens mRNA for tubulin, gamma complex associated protein 2 variant, clone: FCC130D10.
AK092113 - Homo sapiens cDNA FLJ34794 fis, clone NT2NE2005676, highly similar to Gamma-tubulin complex component 2.
AF042379 - Homo sapiens spindle pole body protein spc97 homolog GCP2 mRNA, complete cds.
BC093770 - Homo sapiens tubulin, gamma complex associated protein 2, mRNA (cDNA clone MGC:120805 IMAGE:7939615), complete cds.
BC111957 - Homo sapiens tubulin, gamma complex associated protein 2, mRNA (cDNA clone MGC:138162 IMAGE:8327425), complete cds.
BC143247 - Homo sapiens tubulin, gamma complex associated protein 2, mRNA (cDNA clone MGC:176766 IMAGE:9051749), complete cds.
AK314520 - Homo sapiens cDNA, FLJ95339.
KJ898295 - Synthetic construct Homo sapiens clone ccsbBroadEn_07689 TUBGCP2 gene, encodes complete protein.
AK096087 - Homo sapiens cDNA FLJ38768 fis, clone KIDNE2015313, highly similar to Gamma-tubulin complex component 2.
JD060853 - Sequence 41877 from Patent EP1572962.
JD128360 - Sequence 109384 from Patent EP1572962.
AK128430 - Homo sapiens cDNA FLJ46573 fis, clone THYMU3041603.
BC052368 - Homo sapiens tubulin, gamma complex associated protein 2, mRNA (cDNA clone IMAGE:6303238), complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BSJ2 (Reactome details) participates in the following event(s):

R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
R-HSA-380508 Translocation of NuMA to the centrosomes
R-HSA-380316 Association of NuMA with microtubules
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-380287 Centrosome maturation
R-HSA-68877 Mitotic Prometaphase
R-HSA-69275 G2/M Transition
R-HSA-68886 M Phase
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-1640170 Cell Cycle

-  Other Names for This Gene
  Alternate Gene Symbols: GCP2, GCP2_HUMAN, NM_001256618, O43632, Q5VWX7, Q9BSJ2, uc010qvd.1, uc010qvd.2
UCSC ID: uc010qvd.2
RefSeq Accession: NM_001256618
Protein: Q9BSJ2 (aka GCP2_HUMAN)
CCDS: CCDS58104.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.