Human Gene TUBGCP2 (ENST00000417178.6) Description and Page Index
Description: Homo sapiens tubulin gamma complex associated protein 2 (TUBGCP2), transcript variant 3, mRNA. (from RefSeq NM_001256618)
Gencode Transcript: ENST00000417178.6
Gencode Gene: ENSG00000130640.13
Transcript (Including UTRs)
Position: hg38 chr10:133,278,630-133,309,156 Size: 30,527 Total Exon Count: 17 Strand: -
Position: hg38 chr10:133,279,766-133,299,492 Size: 19,727 Coding Exon Count: 15
Data last updated: 2019-09-04
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Gamma-tubulin complex component 2; Short=GCP-2; Short=hGCP2; AltName: Full=Gamma-ring complex protein 103 kDa; Short=h103p; Short=hGrip103; AltName: Full=Spindle pole body protein Spc97 homolog; Short=hSpc97;
FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. SUBUNIT: Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. TISSUE SPECIFICITY: Ubiquitously expressed. SIMILARITY: Belongs to the TUBGCP family. SEQUENCE CAUTION: Sequence=BC005011; Type=Frameshift; Positions=513;
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR007259 - Spc97_Spc98
Pfam Domains: PF04130 - Spc97 / Spc98 family
ModBase Predicted Comparative 3D Structure on Q9BSJ2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK299564 - Homo sapiens cDNA FLJ58259 complete cds, highly similar to Gamma-tubulin complex component 2. AK297251 - Homo sapiens cDNA FLJ58511 complete cds, highly similar to Gamma-tubulin complex component 2. BC005011 - Homo sapiens cDNA clone IMAGE:3640780, containing frame-shift errors. AK223586 - Homo sapiens mRNA for tubulin, gamma complex associated protein 2 variant, clone: FCC130D10. AK092113 - Homo sapiens cDNA FLJ34794 fis, clone NT2NE2005676, highly similar to Gamma-tubulin complex component 2. AF042379 - Homo sapiens spindle pole body protein spc97 homolog GCP2 mRNA, complete cds. BC093770 - Homo sapiens tubulin, gamma complex associated protein 2, mRNA (cDNA clone MGC:120805 IMAGE:7939615), complete cds. BC111957 - Homo sapiens tubulin, gamma complex associated protein 2, mRNA (cDNA clone MGC:138162 IMAGE:8327425), complete cds. BC143247 - Homo sapiens tubulin, gamma complex associated protein 2, mRNA (cDNA clone MGC:176766 IMAGE:9051749), complete cds. AK314520 - Homo sapiens cDNA, FLJ95339. KJ898295 - Synthetic construct Homo sapiens clone ccsbBroadEn_07689 TUBGCP2 gene, encodes complete protein. AK096087 - Homo sapiens cDNA FLJ38768 fis, clone KIDNE2015313, highly similar to Gamma-tubulin complex component 2. JD060853 - Sequence 41877 from Patent EP1572962. JD128360 - Sequence 109384 from Patent EP1572962. AK128430 - Homo sapiens cDNA FLJ46573 fis, clone THYMU3041603. BC052368 - Homo sapiens tubulin, gamma complex associated protein 2, mRNA (cDNA clone IMAGE:6303238), complete cds.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: GCP2, GCP2_HUMAN, NM_001256618, O43632, Q5VWX7, Q9BSJ2, uc010qvd.1, uc010qvd.2 UCSC ID: uc010qvd.2 RefSeq Accession: NM_001256618
(aka GCP2_HUMAN) Q9BSJ2
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.