Human Gene TUBGCP2 (ENST00000417178.6) Description and Page Index
  Description: Homo sapiens tubulin gamma complex associated protein 2 (TUBGCP2), transcript variant 3, mRNA. (from RefSeq NM_001256618)
Gencode Transcript: ENST00000417178.6
Gencode Gene: ENSG00000130640.13
Transcript (Including UTRs)
   Position: hg38 chr10:133,278,630-133,309,156 Size: 30,527 Total Exon Count: 17 Strand: -
Coding Region
   Position: hg38 chr10:133,279,766-133,299,492 Size: 19,727 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:133,278,630-133,309,156)mRNA (may differ from genome)Protein (772 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
PubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Gamma-tubulin complex component 2; Short=GCP-2; Short=hGCP2; AltName: Full=Gamma-ring complex protein 103 kDa; Short=h103p; Short=hGrip103; AltName: Full=Spindle pole body protein Spc97 homolog; Short=hSpc97;
FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
SUBUNIT: Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome.
TISSUE SPECIFICITY: Ubiquitously expressed.
SIMILARITY: Belongs to the TUBGCP family.
SEQUENCE CAUTION: Sequence=BC005011; Type=Frameshift; Positions=513;

-  MalaCards Disease Associations
  MalaCards Gene Search: TUBGCP2
Diseases sorted by gene-association score: cardiomyopathy, dilated, 1p (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 26.98 RPKM in Testis
Total median expression: 871.95 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -234.80574-0.409 Picture PostScript Text
3' UTR -480.801136-0.423 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007259 - Spc97_Spc98

Pfam Domains:
PF04130 - Spc97 / Spc98 family

ModBase Predicted Comparative 3D Structure on Q9BSJ2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0043015 gamma-tubulin binding
GO:0051011 microtubule minus-end binding

Biological Process:
GO:0000226 microtubule cytoskeleton organization
GO:0007020 microtubule nucleation
GO:0031122 cytoplasmic microtubule organization
GO:0051298 centrosome duplication
GO:0051321 meiotic cell cycle
GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center
GO:0065003 macromolecular complex assembly
GO:0090307 mitotic spindle assembly

Cellular Component:
GO:0000922 spindle pole
GO:0000923 equatorial microtubule organizing center
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005881 cytoplasmic microtubule
GO:0008275 gamma-tubulin small complex
GO:0016020 membrane
GO:0005816 spindle pole body

-  Descriptions from all associated GenBank mRNAs
  AK299564 - Homo sapiens cDNA FLJ58259 complete cds, highly similar to Gamma-tubulin complex component 2.
AK297251 - Homo sapiens cDNA FLJ58511 complete cds, highly similar to Gamma-tubulin complex component 2.
BC005011 - Homo sapiens cDNA clone IMAGE:3640780, containing frame-shift errors.
AK223586 - Homo sapiens mRNA for tubulin, gamma complex associated protein 2 variant, clone: FCC130D10.
AK092113 - Homo sapiens cDNA FLJ34794 fis, clone NT2NE2005676, highly similar to Gamma-tubulin complex component 2.
AF042379 - Homo sapiens spindle pole body protein spc97 homolog GCP2 mRNA, complete cds.
BC093770 - Homo sapiens tubulin, gamma complex associated protein 2, mRNA (cDNA clone MGC:120805 IMAGE:7939615), complete cds.
BC111957 - Homo sapiens tubulin, gamma complex associated protein 2, mRNA (cDNA clone MGC:138162 IMAGE:8327425), complete cds.
BC143247 - Homo sapiens tubulin, gamma complex associated protein 2, mRNA (cDNA clone MGC:176766 IMAGE:9051749), complete cds.
AK314520 - Homo sapiens cDNA, FLJ95339.
KJ898295 - Synthetic construct Homo sapiens clone ccsbBroadEn_07689 TUBGCP2 gene, encodes complete protein.
AK096087 - Homo sapiens cDNA FLJ38768 fis, clone KIDNE2015313, highly similar to Gamma-tubulin complex component 2.
JD060853 - Sequence 41877 from Patent EP1572962.
JD128360 - Sequence 109384 from Patent EP1572962.
AK128430 - Homo sapiens cDNA FLJ46573 fis, clone THYMU3041603.
BC052368 - Homo sapiens tubulin, gamma complex associated protein 2, mRNA (cDNA clone IMAGE:6303238), complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BSJ2 (Reactome details) participates in the following event(s):

R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
R-HSA-380508 Translocation of NuMA to the centrosomes
R-HSA-380316 Association of NuMA with microtubules
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-380287 Centrosome maturation
R-HSA-68877 Mitotic Prometaphase
R-HSA-69275 G2/M Transition
R-HSA-68886 M Phase
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-1640170 Cell Cycle

-  Other Names for This Gene
  Alternate Gene Symbols: GCP2, GCP2_HUMAN, NM_001256618, O43632, Q5VWX7, Q9BSJ2, uc010qvd.1, uc010qvd.2
UCSC ID: uc010qvd.2
RefSeq Accession: NM_001256618
Protein: Q9BSJ2 (aka GCP2_HUMAN)
CCDS: CCDS58104.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.