Human Gene SULT1C2 (ENST00000409880.5) Description and Page Index
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt B8ZZF7)
RefSeq Summary (NM_001056): Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000409880.5
Gencode Gene: ENSG00000198203.10
Transcript (Including UTRs)
   Position: hg38 chr2:108,288,915-108,308,713 Size: 19,799 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr2:108,293,668-108,308,464 Size: 14,797 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:108,288,915-108,308,713)mRNA (may differ from genome)Protein (259 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: B8ZZF7_HUMAN
DESCRIPTION: SubName: Full=Sulfotransferase 1C2;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: SULT1C2
Diseases sorted by gene-association score: colon mucinous adenocarcinoma (16), macular corneal dystrophy (11), stromal dystrophy (8), spherocytosis, type 3 (6), corneal dystrophy, avellino type (6), spherocytosis, type 2 (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • D004052 Diethylnitrosamine
  • C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene
  • C016403 2,4-dinitrotoluene
  • C023514 2,6-dinitrotoluene
  • D015073 2-Acetylaminofluorene
  • D015081 2-Naphthylamine
  • C017821 2-amino-3-methyl-9H-pyrido(2,3-b)indole
  • C024836 4-nitrophenol
  • C521334 5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.18 RPKM in Kidney - Cortex
Total median expression: 94.03 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -51.40177-0.290 Picture PostScript Text
3' UTR -37.70249-0.151 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000863 - Sulfotransferase_dom

Pfam Domains:
PF00685 - Sulfotransferase domain

ModBase Predicted Comparative 3D Structure on B8ZZF7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein Sequence     
Alignment     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008146 sulfotransferase activity
GO:0016740 transferase activity


-  Descriptions from all associated GenBank mRNAs
  AF186252 - Homo sapiens sulfotransferase 1C1 (SULT1C1) mRNA, complete cds, alternatively spliced.
AF186255 - Homo sapiens sulfotransferase 1C1 (SULT1C1) mRNA, complete cds, alternatively spliced.
AF186251 - Homo sapiens sulfotransferase 1C1 (SULT1C1) mRNA, complete cds, alternatively spliced.
AF186254 - Homo sapiens sulfotransferase 1C1 (SULT1C1) mRNA, complete cds, alternatively spliced.
AK297086 - Homo sapiens cDNA FLJ51893 complete cds, highly similar to Sulfotransferase 1C1 (EC 2.8.2.-).
AK313193 - Homo sapiens cDNA, FLJ93692, Homo sapiens sulfotransferase family, cytosolic, 1C, member 1 (SULT1C1), mRNA.
AK298306 - Homo sapiens cDNA FLJ52581 complete cds, highly similar to Sulfotransferase 1C1 (EC 2.8.2.-).
JD065095 - Sequence 46119 from Patent EP1572962.
U66036 - Human sulfotransferase mRNA, complete cds.
AF186253 - Homo sapiens sulfotransferase 1C1 (SULT1C1) mRNA, complete cds, alternatively spliced.
AF186256 - Homo sapiens sulfotransferase 1C1 (SULT1C1) mRNA, complete cds, alternatively spliced.
AB008164 - Homo sapiens mRNA for ST1C2, complete cds.
AF026303 - Homo sapiens sulfotransferase mRNA, complete cds.
BC005353 - Homo sapiens sulfotransferase family, cytosolic, 1C, member 2, mRNA (cDNA clone MGC:12452 IMAGE:4051264), complete cds.
JD217285 - Sequence 198309 from Patent EP1572962.
JD195682 - Sequence 176706 from Patent EP1572962.
BT006951 - Homo sapiens sulfotransferase family, cytosolic, 1C, member 1 mRNA, complete cds.
KJ892228 - Synthetic construct Homo sapiens clone ccsbBroadEn_01622 SULT1C2 gene, encodes complete protein.
KR710143 - Synthetic construct Homo sapiens clone CCSBHm_00010056 SULT1C2 (SULT1C2) mRNA, encodes complete protein.
KR710144 - Synthetic construct Homo sapiens clone CCSBHm_00010057 SULT1C2 (SULT1C2) mRNA, encodes complete protein.
KR710145 - Synthetic construct Homo sapiens clone CCSBHm_00010058 SULT1C2 (SULT1C2) mRNA, encodes complete protein.
AL832145 - Homo sapiens mRNA; cDNA DKFZp686K19111 (from clone DKFZp686K19111).

-  Other Names for This Gene
  Alternate Gene Symbols: AK297086, B8ZZF7, B8ZZF7_HUMAN, uc061mrl.1
UCSC ID: uc061mrl.1
RefSeq Accession: NM_001056
Protein: B8ZZF7

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.