Human Gene PLEKHB2 (ENST00000409612.5) Description and Page Index
Description: Homo sapiens pleckstrin homology domain containing B2 (PLEKHB2), transcript variant 14, mRNA. (from RefSeq NM_001309452)
Gencode Transcript: ENST00000409612.5
Gencode Gene: ENSG00000115762.16
Transcript (Including UTRs)
Position: hg38 chr2:131,107,556-131,147,797 Size: 40,242 Total Exon Count: 8 Strand: +
Position: hg38 chr2:131,120,942-131,146,773 Size: 25,832 Coding Exon Count: 7
Data last updated: 2019-09-04
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Pleckstrin homology domain-containing family B member 2; Short=PH domain-containing family B member 2; AltName: Full=Evectin-2;
FUNCTION: Involved in retrograde transport of recycling endosomes. SUBCELLULAR LOCATION: Recycling endosome membrane; Peripheral membrane protein. Note=Specifically detected in tubulovesicular structures, and colocalizes with TFNR. DOMAIN: The PH domain specifically binds phosphatidylserine, which is enriched in recycling endosome membranes, it doesn't recognize PIPs. SIMILARITY: Contains 1 PH domain.
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
Pfam Domains: PF00169 - PH domain
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q96CS7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LP895394 - Sequence 258 from Patent EP3253886. BC001428 - Homo sapiens pleckstrin homology domain containing, family B (evectins) member 2, mRNA (cDNA clone MGC:1005 IMAGE:3139876), complete cds. DQ895139 - Synthetic construct Homo sapiens clone IMAGE:100009599; FLH181721.01L; RZPDo839G06135D pleckstrin homology domain containing, family B (evectins) member 2 (PLEKHB2) gene, encodes complete protein. DQ891953 - Synthetic construct clone IMAGE:100004583; FLH181725.01X; RZPDo839G06136D pleckstrin homology domain containing, family B (evectins) member 2 (PLEKHB2) gene, encodes complete protein. AK126289 - Homo sapiens cDNA FLJ44309 fis, clone TRACH2025535, highly similar to Mus musculus evectin-2 (Evt2). AK302770 - Homo sapiens cDNA FLJ54089 complete cds, highly similar to Pleckstrin homology domain-containing family B member 2. AK293880 - Homo sapiens cDNA FLJ52534 complete cds, highly similar to Pleckstrin homology domain-containing family B member 2. AK000790 - Homo sapiens cDNA FLJ20783 fis, clone COL03108. AK223338 - Homo sapiens mRNA for pleckstrin homology domain containing, family B (evectins) member 2 variant, clone: TST02947. AK296008 - Homo sapiens cDNA FLJ59903 complete cds, highly similar to Pleckstrin homology domain-containing familyB member 2. BC050695 - Homo sapiens pleckstrin homology domain containing, family B (evectins) member 2, mRNA (cDNA clone MGC:60279 IMAGE:6162960), complete cds. BC013991 - Homo sapiens pleckstrin homology domain containing, family B (evectins) member 2, mRNA (cDNA clone MGC:19978 IMAGE:3639839), complete cds. AK123710 - Homo sapiens cDNA FLJ41716 fis, clone HLUNG2012546, highly similar to Pleckstrin homology domain-containing family B member 2. AK093730 - Homo sapiens cDNA FLJ36411 fis, clone THYMU2010699, highly similar to Mus musculus evectin-2 (Evt2) mRNA. AX748281 - Sequence 1806 from Patent EP1308459. CU680728 - Synthetic construct Homo sapiens gateway clone IMAGE:100023322 5' read PLEKHB2 mRNA. KJ894117 - Synthetic construct Homo sapiens clone ccsbBroadEn_03511 PLEKHB2 gene, encodes complete protein. DQ581595 - Homo sapiens piRNA piR-49707, complete sequence. DQ572159 - Homo sapiens piRNA piR-40271, complete sequence. DQ572774 - Homo sapiens piRNA piR-40886, complete sequence. JD501188 - Sequence 482212 from Patent EP1572962. JD485469 - Sequence 466493 from Patent EP1572962. JD484396 - Sequence 465420 from Patent EP1572962. JD137176 - Sequence 118200 from Patent EP1572962. DQ584420 - Homo sapiens piRNA piR-51532, complete sequence. JD566529 - Sequence 547553 from Patent EP1572962. JD040765 - Sequence 21789 from Patent EP1572962. JD241660 - Sequence 222684 from Patent EP1572962. JD078335 - Sequence 59359 from Patent EP1572962. JD143266 - Sequence 124290 from Patent EP1572962. JD420329 - Sequence 401353 from Patent EP1572962. JD295593 - Sequence 276617 from Patent EP1572962. DQ589844 - Homo sapiens piRNA piR-56956, complete sequence. DQ589845 - Homo sapiens piRNA piR-56957, complete sequence. JD533518 - Sequence 514542 from Patent EP1572962. JD101769 - Sequence 82793 from Patent EP1572962. JD452653 - Sequence 433677 from Patent EP1572962. JD440722 - Sequence 421746 from Patent EP1572962. JD444772 - Sequence 425796 from Patent EP1572962. JD177432 - Sequence 158456 from Patent EP1572962. JD096303 - Sequence 77327 from Patent EP1572962. JD044116 - Sequence 25140 from Patent EP1572962. JD331645 - Sequence 312669 from Patent EP1572962. JD182204 - Sequence 163228 from Patent EP1572962. JD349515 - Sequence 330539 from Patent EP1572962. JD243563 - Sequence 224587 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: EVT2, NM_001309452, PKHB2_HUMAN, Q53FF1, Q53TH7, Q86W37, Q96CS7, Q9BV75, Q9NWK1, uc061nwf.1 UCSC ID: uc061nwf.1 RefSeq Accession: NM_001100623
(aka PKHB2_HUMAN) Q96CS7
CCDS: CCDS2166.1, CCDS46413.1, CCDS58730.1
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.