Human Gene EPPIN (ENST00000409554.1) Description and Page Index
Description: Homo sapiens epididymal peptidase inhibitor (EPPIN), transcript variant 2, mRNA. (from RefSeq NM_001302861) RefSeq Summary (NM_020398): This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]. Gencode Transcript: ENST00000409554.1 Gencode Gene: ENSG00000101448.13 Transcript (Including UTRs) Position: hg38 chr20:45,541,833-45,547,752 Size: 5,920 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr20:45,542,747-45,547,357 Size: 4,611 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on B7ZBA9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.