Human Gene TCHP (ENST00000405876.9) Description and Page Index
  Description: Homo sapiens trichoplein keratin filament binding (TCHP), transcript variant 2, mRNA. (from RefSeq NM_001143852)
Gencode Transcript: ENST00000405876.9
Gencode Gene: ENSG00000139437.18
Transcript (Including UTRs)
   Position: hg38 chr12:109,900,274-109,918,069 Size: 17,796 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg38 chr12:109,903,027-109,916,623 Size: 13,597 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr12:109,900,274-109,918,069)mRNA (may differ from genome)Protein (498 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Trichoplein keratin filament-binding protein; Short=Protein TCHP; AltName: Full=Mitochondrial protein with oncostatic activity; Short=Mitostatin; AltName: Full=Tumor suppressor protein;
FUNCTION: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.
SUBUNIT: Interacts specifically with keratin proteins including, KRT5, KRT6A, KRT8, KRT14, KRT16 and KRT18.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion.
TISSUE SPECIFICITY: Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis.
SIMILARITY: Belongs to the TCHP family.

-  MalaCards Disease Associations
  MalaCards Gene Search: TCHP
Diseases sorted by gene-association score: vulvar sarcoma (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.48 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 385.39 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -61.10153-0.399 Picture PostScript Text
3' UTR -404.601446-0.280 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026773 - TCHP/CCDC11

ModBase Predicted Comparative 3D Structure on Q9BT92
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006915 apoptotic process
GO:0030030 cell projection organization
GO:0030308 negative regulation of cell growth
GO:1902018 negative regulation of cilium assembly

Cellular Component:
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
GO:0030057 desmosome
GO:0045095 keratin filament
GO:0045179 apical cortex
GO:0097539 ciliary transition fiber

-  Descriptions from all associated GenBank mRNAs
  LF213896 - JP 2014500723-A/21399: Polycomb-Associated Non-Coding RNAs.
MA449473 - JP 2018138019-A/21399: Polycomb-Associated Non-Coding RNAs.
AK092736 - Homo sapiens cDNA FLJ35417 fis, clone SMINT2000747.
AX747696 - Sequence 1221 from Patent EP1308459.
BC004285 - Homo sapiens trichoplein, keratin filament binding, mRNA (cDNA clone MGC:10854 IMAGE:3617849), complete cds.
AK301262 - Homo sapiens cDNA FLJ58860 complete cds, highly similar to Homo sapiens trichoplein, mRNA.
JD056416 - Sequence 37440 from Patent EP1572962.
JD141225 - Sequence 122249 from Patent EP1572962.
AY007230 - Homo sapiens mitostatin mRNA, complete cds.
BC022838 - Homo sapiens trichoplein, keratin filament binding, mRNA (cDNA clone IMAGE:4897871).
EU176406 - Synthetic construct Homo sapiens clone IMAGE:100006496; FLH191545.01X; RZPDo839D04252D trichoplein, keratin filament binding (TCHP) gene, encodes complete protein.
EU176751 - Synthetic construct Homo sapiens clone IMAGE:100011627; FLH263975.01L; RZPDo839B02245D trichoplein, keratin filament binding (TCHP) gene, encodes complete protein.
KJ894954 - Synthetic construct Homo sapiens clone ccsbBroadEn_04348 TCHP gene, encodes complete protein.
LF206925 - JP 2014500723-A/14428: Polycomb-Associated Non-Coding RNAs.
MA442502 - JP 2018138019-A/14428: Polycomb-Associated Non-Coding RNAs.
BX648596 - Homo sapiens mRNA; cDNA DKFZp686F12209 (from clone DKFZp686F12209).
AY210413 - Homo sapiens cell-line A-431 cell-type epidermoid carcinoma mRNA, partial sequence.
JD308717 - Sequence 289741 from Patent EP1572962.
JD504861 - Sequence 485885 from Patent EP1572962.
JD213768 - Sequence 194792 from Patent EP1572962.
JD252386 - Sequence 233410 from Patent EP1572962.
JD449849 - Sequence 430873 from Patent EP1572962.
JD463604 - Sequence 444628 from Patent EP1572962.
DQ582793 - Homo sapiens piRNA piR-32905, complete sequence.
JD217825 - Sequence 198849 from Patent EP1572962.
JD095266 - Sequence 76290 from Patent EP1572962.
JD304652 - Sequence 285676 from Patent EP1572962.
JD457007 - Sequence 438031 from Patent EP1572962.
AK000079 - Homo sapiens cDNA FLJ20072 fis, clone COL01976.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001143852, Q8NAG0, Q9BT92, TCHP_HUMAN, uc001tpn.1, uc001tpn.2, uc001tpn.3, uc001tpn.4, uc001tpn.5
UCSC ID: uc001tpn.5
RefSeq Accession: NM_001143852
Protein: Q9BT92 (aka TCHP_HUMAN)
CCDS: CCDS9137.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.