Human Gene NRG3 (ENST00000404576.6) Description and Page Index
Description: neuregulin 3 (from HGNC NRG3) RefSeq Summary (NM_001165973): This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]. Gencode Transcript: ENST00000404576.6 Gencode Gene: ENSG00000185737.13 Transcript (Including UTRs) Position: hg38 chr10:81,877,961-82,985,605 Size: 1,107,645 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr10:81,877,961-82,985,605 Size: 1,107,645 Coding Exon Count: 10
ModBase Predicted Comparative 3D Structure on D9ZHQ6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.