Human Gene NRG3 (ENST00000404576.6) Description and Page Index
  Description: neuregulin 3 (from HGNC NRG3)
RefSeq Summary (NM_001165973): This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009].
Gencode Transcript: ENST00000404576.6
Gencode Gene: ENSG00000185737.13
Transcript (Including UTRs)
   Position: hg38 chr10:81,877,961-82,985,605 Size: 1,107,645 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg38 chr10:81,877,961-82,985,605 Size: 1,107,645 Coding Exon Count: 10 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:81,877,961-82,985,605)mRNA (may differ from genome)Protein (500 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: NRG3
Diseases sorted by gene-association score: schizophrenia (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.53 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 46.91 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000742 - EG-like_dom
IPR013032 - EGF-like_CS
IPR002154 - Neuregulin_1_C

Pfam Domains:
PF02158 - Neuregulin family

ModBase Predicted Comparative 3D Structure on D9ZHQ6
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC136811 - Homo sapiens neuregulin 3, mRNA (cDNA clone MGC:168424 IMAGE:9020801), complete cds.
DQ001411 - Homo sapiens neuregulin-3 (NRG3) mRNA, complete cds, alternatively spliced.
HM068873 - Homo sapiens neuregulin 3 variant 1 (NRG3) mRNA, complete cds, alternatively spliced.
HM068874 - Homo sapiens neuregulin 3 variant 3 (NRG3) mRNA, complete cds, alternatively spliced.
AK296563 - Homo sapiens cDNA FLJ54417 complete cds, highly similar to Pro-neuregulin-3, membrane-bound isoform precursor.
DQ338459 - Homo sapiens neuregulin-3-like polypeptide mRNA, complete cds.
DQ857894 - Homo sapiens neuregulin 3 (NRG3) mRNA, complete cds, alternatively spliced.
AK122886 - Homo sapiens cDNA FLJ16534 fis, clone OCBBF2029471, highly similar to Pro-neuregulin-3, membrane-bound isoform precursor.
HM068875 - Homo sapiens neuregulin 3 variant 4 (NRG3) mRNA, complete cds, alternatively spliced.
HM068880 - Homo sapiens neuregulin 3 variant 9 (NRG3) mRNA, complete cds, alternatively spliced.
HM068881 - Homo sapiens neuregulin 3 variant 10 (NRG3) mRNA, complete cds, alternatively spliced.
HM068882 - Homo sapiens neuregulin 3 variant 11 (NRG3) mRNA, complete cds, alternatively spliced.
HM068883 - Homo sapiens neuregulin 3 variant 12 (NRG3) mRNA, complete cds, alternatively spliced.
HM068884 - Homo sapiens neuregulin 3 variant 13 (NRG3) mRNA, complete cds, alternatively spliced.
HM068876 - Homo sapiens neuregulin 3 variant 5 (NRG3) mRNA, complete cds, alternatively spliced.
HM068877 - Homo sapiens neuregulin 3 variant 6 (NRG3) mRNA, complete cds, alternatively spliced.
HM068878 - Homo sapiens neuregulin 3 variant 7 (NRG3) mRNA, complete cds, alternatively spliced.
HM068879 - Homo sapiens neuregulin 3 variant 8 (NRG3) mRNA, complete cds, alternatively spliced.
HM068885 - Homo sapiens neuregulin 3 variant 14 (NRG3) mRNA, complete cds, alternatively spliced.
AK098823 - Homo sapiens cDNA FLJ25957 fis, clone TST05491, highly similar to Mus musculus neuregulin-3 (NRG3) mRNA.
BC143665 - Homo sapiens cDNA clone IMAGE:9052179.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04012 - ErbB signaling pathway

BioCarta from NCI Cancer Genome Anatomy Project
h_agrPathway - Agrin in Postsynaptic Differentiation
h_erbB4pathway - g-Secretase mediated ErbB4 Signaling Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: D9ZHQ6, D9ZHQ6_HUMAN, HM068883, uc021pve.1, uc021pve.2
UCSC ID: uc021pve.2
RefSeq Accession: NM_001165973
Protein: D9ZHQ6 CCDS: CCDS53547.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.