Human Gene PLEKHB2 (ENST00000403716.5) Description and Page Index
  Description: Homo sapiens pleckstrin homology domain containing B2 (PLEKHB2), transcript variant 5, mRNA. (from RefSeq NM_001267063)
Gencode Transcript: ENST00000403716.5
Gencode Gene: ENSG00000115762.16
Transcript (Including UTRs)
   Position: hg38 chr2:131,104,847-131,149,851 Size: 45,005 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg38 chr2:131,120,942-131,146,773 Size: 25,832 Coding Exon Count: 8 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:131,104,847-131,149,851)mRNA (may differ from genome)Protein (236 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIOMIMPubMedStanford SOURCEUniProtKB
Wikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: PLEKHB2
Diseases sorted by gene-association score: exudative vitreoretinopathy (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.74 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 854.82 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -191.20560-0.341 Picture PostScript Text
3' UTR -960.603078-0.312 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  LP895394 - Sequence 258 from Patent EP3253886.
BC001428 - Homo sapiens pleckstrin homology domain containing, family B (evectins) member 2, mRNA (cDNA clone MGC:1005 IMAGE:3139876), complete cds.
DQ895139 - Synthetic construct Homo sapiens clone IMAGE:100009599; FLH181721.01L; RZPDo839G06135D pleckstrin homology domain containing, family B (evectins) member 2 (PLEKHB2) gene, encodes complete protein.
DQ891953 - Synthetic construct clone IMAGE:100004583; FLH181725.01X; RZPDo839G06136D pleckstrin homology domain containing, family B (evectins) member 2 (PLEKHB2) gene, encodes complete protein.
AK126289 - Homo sapiens cDNA FLJ44309 fis, clone TRACH2025535, highly similar to Mus musculus evectin-2 (Evt2).
AK302770 - Homo sapiens cDNA FLJ54089 complete cds, highly similar to Pleckstrin homology domain-containing family B member 2.
AK293880 - Homo sapiens cDNA FLJ52534 complete cds, highly similar to Pleckstrin homology domain-containing family B member 2.
AK000790 - Homo sapiens cDNA FLJ20783 fis, clone COL03108.
AK223338 - Homo sapiens mRNA for pleckstrin homology domain containing, family B (evectins) member 2 variant, clone: TST02947.
AK296008 - Homo sapiens cDNA FLJ59903 complete cds, highly similar to Pleckstrin homology domain-containing familyB member 2.
BC050695 - Homo sapiens pleckstrin homology domain containing, family B (evectins) member 2, mRNA (cDNA clone MGC:60279 IMAGE:6162960), complete cds.
BC013991 - Homo sapiens pleckstrin homology domain containing, family B (evectins) member 2, mRNA (cDNA clone MGC:19978 IMAGE:3639839), complete cds.
AK123710 - Homo sapiens cDNA FLJ41716 fis, clone HLUNG2012546, highly similar to Pleckstrin homology domain-containing family B member 2.
AK093730 - Homo sapiens cDNA FLJ36411 fis, clone THYMU2010699, highly similar to Mus musculus evectin-2 (Evt2) mRNA.
AX748281 - Sequence 1806 from Patent EP1308459.
CU680728 - Synthetic construct Homo sapiens gateway clone IMAGE:100023322 5' read PLEKHB2 mRNA.
KJ894117 - Synthetic construct Homo sapiens clone ccsbBroadEn_03511 PLEKHB2 gene, encodes complete protein.
DQ581595 - Homo sapiens piRNA piR-49707, complete sequence.
DQ572159 - Homo sapiens piRNA piR-40271, complete sequence.
DQ572774 - Homo sapiens piRNA piR-40886, complete sequence.
JD501188 - Sequence 482212 from Patent EP1572962.
JD485469 - Sequence 466493 from Patent EP1572962.
JD484396 - Sequence 465420 from Patent EP1572962.
JD137176 - Sequence 118200 from Patent EP1572962.
DQ584420 - Homo sapiens piRNA piR-51532, complete sequence.
JD566529 - Sequence 547553 from Patent EP1572962.
JD040765 - Sequence 21789 from Patent EP1572962.
JD241660 - Sequence 222684 from Patent EP1572962.
JD078335 - Sequence 59359 from Patent EP1572962.
JD143266 - Sequence 124290 from Patent EP1572962.
JD420329 - Sequence 401353 from Patent EP1572962.
JD295593 - Sequence 276617 from Patent EP1572962.
DQ589844 - Homo sapiens piRNA piR-56956, complete sequence.
DQ589845 - Homo sapiens piRNA piR-56957, complete sequence.
JD533518 - Sequence 514542 from Patent EP1572962.
JD101769 - Sequence 82793 from Patent EP1572962.
JD452653 - Sequence 433677 from Patent EP1572962.
JD440722 - Sequence 421746 from Patent EP1572962.
JD444772 - Sequence 425796 from Patent EP1572962.
JD177432 - Sequence 158456 from Patent EP1572962.
JD096303 - Sequence 77327 from Patent EP1572962.
JD044116 - Sequence 25140 from Patent EP1572962.
JD331645 - Sequence 312669 from Patent EP1572962.
JD182204 - Sequence 163228 from Patent EP1572962.
JD349515 - Sequence 330539 from Patent EP1572962.
JD243563 - Sequence 224587 from Patent EP1572962.
AK074259 - Homo sapiens cDNA FLJ23679 fis, clone HEP09084.
AK054998 - Homo sapiens cDNA FLJ30436 fis, clone BRACE2009037.
DQ592809 - Homo sapiens piRNA piR-59921, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A0A0MSE9, NM_001267063, uc031rpd.1, uc031rpd.2
UCSC ID: uc031rpd.2
RefSeq Accession: NM_001267062
CCDS: CCDS74576.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.