Human Gene MPST (ENST00000401419.7) Description and Page Index
Description: Homo sapiens mercaptopyruvate sulfurtransferase (MPST), transcript variant 2, mRNA. (from RefSeq NM_001013436) RefSeq Summary (NM_001013436): This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: HM005513.1, CX866643.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## Gencode Transcript: ENST00000401419.7 Gencode Gene: ENSG00000128309.16 Transcript (Including UTRs) Position: hg38 chr22:37,019,635-37,029,801 Size: 10,167 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr22:37,024,216-37,029,514 Size: 5,299 Coding Exon Count: 2
ID:THTM_HUMAN DESCRIPTION: RecName: Full=3-mercaptopyruvate sulfurtransferase; Short=MST; EC=220.127.116.11; FUNCTION: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. May have a role in cyanide degradation or in thiosulfate biosynthesis. CATALYTIC ACTIVITY: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate. SUBUNIT: Monomer or disulfide-linked homodimer (By similarity). SUBCELLULAR LOCATION: Cytoplasm. DOMAIN: The structure consists of 2 domains of very similar conformation, suggesting a common evolutionary origin. However, the sequences of the 2 domains are very different. SIMILARITY: Contains 2 rhodanese domains. CAUTION: Was originally (PubMed:1953758) thought to be rhodanese.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P25325
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.