Human Gene AC245128.1 (ENST00000400864.3) Description and Page Index
  Description: Homo sapiens mRNA for killer-cell Ig-like receptor (KIR3DP1 gene), allele KIR3DP1*004. (from mRNA AJ630586)
RefSeq Summary (NM_014513): Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF208054.1, L76672.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000400864.3
Gencode Gene: ENSG00000215765.3
Transcript (Including UTRs)
   Position: hg38 chr19:54,724,496-54,798,285 Size: 73,790 Total Exon Count: 6 Strand: +


Page IndexSequence and LinksRNA-Seq ExpressionMicroarray ExpressionOther SpeciesmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:54,724,496-54,798,285)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
ExonPrimerPubMedStanford SOURCE

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.07 RPKM in Whole Blood
Total median expression: 0.12 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AM851002 - Homo sapiens mRNA for killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 (KIR2DS3 gene), allele KIR2DS3*002EM6.
AF208054 - Homo sapiens non-inhibitory killer-cell Ig-like receptor KIR (KIR2DS5) mRNA, complete cds.
L76670 - Homo sapiens nkat7 mRNA, complete cds.
KJ904360 - Synthetic construct Homo sapiens clone ccsbBroadEn_13754 KIR2DS2 gene, encodes complete protein.
BC160061 - Synthetic construct Homo sapiens clone IMAGE:100063997, MGC:193176 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5 (KIR2DS5) mRNA, encodes complete protein.
BC108917 - Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2, mRNA (cDNA clone MGC:120018 IMAGE:40017299), complete cds.
BC126856 - Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2, mRNA (cDNA clone MGC:120020 IMAGE:40017301), complete cds.
LS974116 - Homo sapiens mRNA for KIR2DS5 protein (KIR2DS5 gene), isolate 82, allele Ins57bp_(Cry)_hKIR2DS5_00201.
BC125146 - Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2, mRNA (cDNA clone IMAGE:40120229), partial cds.
AJ630586 - Homo sapiens mRNA for killer-cell Ig-like receptor (KIR3DP1 gene), allele KIR3DP1*004.
BC096725 - Homo sapiens cDNA clone IMAGE:40026982, containing frame-shift errors.
AM999888 - Homo sapiens mRNA for killer-cell immunoglobulin-like receptor (KIR2DL1-KIR2DS1 hybrid gene), clone pCR4-TOPO_C9.
L76662 - Homo sapiens nkat2a mRNA, complete cds.
L76663 - Homo sapiens nkat2b mRNA, complete cds.
BC032422 - Homo sapiens killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3, mRNA (cDNA clone MGC:39949 IMAGE:5220339), complete cds.
AF022048 - Homo sapiens natural killer cell inhibitory receptor KIR2DL3 variant mRNA, complete cds.
X98858 - H.sapiens mRNA for HLA-C specific activatory NK receptor.
LT963640 - Homo sapiens mRNA for KIR2DL protein (KIR2DL1/3DL2 gene), isolate 01, 04, allele KIR2DL1/3DL2.
AF074087 - Homo sapiens killer cell inhibitory receptor short form (KIR2DS2) mRNA, alternatively spliced, partial cds.
AF272389 - Homo sapiens natural killer cell immunoglobulin-like receptor (KIR2DS5) mRNA, partial cds.
AF285435 - Homo sapiens clone KIR2DL3v2 killer-cell Ig-like receptor mRNA, partial cds.
AF285437 - Homo sapiens clone KIR2DS1v2 killer-cell Ig-like receptor mRNA, partial cds.
JD022847 - Sequence 3871 from Patent EP1572962.
BC136283 - Homo sapiens killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3, mRNA (cDNA clone MGC:167893 IMAGE:9020270), complete cds.
BC143802 - Homo sapiens killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3, mRNA (cDNA clone MGC:177333 IMAGE:9052316), complete cds.
AY366241 - Homo sapiens natural killer cell inhibitory receptor (KIR2DL1) mRNA, KIR2DL1*006 allele, complete cds.
AY366237 - Homo sapiens natural killer cell inhibitory receptor (KIR2DL1) mRNA, KIR2DL1*00302 allele, complete cds.
BC069344 - Homo sapiens killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1, mRNA (cDNA clone MGC:97081 IMAGE:7262296), complete cds.
AF352324 - Homo sapiens killer cell Ig-like receptor CD158z (KIR3DL7) mRNA, complete cds.
BC096725 - Homo sapiens cDNA clone IMAGE:40026982, containing frame-shift errors.
KJ900024 - Synthetic construct Homo sapiens clone ccsbBroadEn_09418 KIR3DL3 gene, encodes complete protein.
AJ938052 - Homo sapiens mRNA for killer cell immunoglobulin-like receptor (KIR3DL3 gene), variant KIRC1 TM1.
AJ938053 - Homo sapiens mRNA for killer cell immunoglobulin-like receptor (KIR3DL3 gene), variant KIRC1 TM2.
AJ938054 - Homo sapiens mRNA for killer cell immunoglobulin-like receptor (KIR3DL3 gene), variant KIRC1 TM3.
AJ938055 - Homo sapiens mRNA for killer cell immunoglobulin-like receptor (KIR3DL3 gene), variant 44a.
AJ938056 - Homo sapiens mRNA for killer cell immunoglobulin-like receptor (KIR3DL3 gene), variant 44b TM1.
AJ938057 - Homo sapiens mRNA for killer cell immunoglobulin-like receptor (KIR3DL3 gene), variant 44b TM2.
AJ938058 - Homo sapiens mRNA for killer cell immunoglobulin-like receptor (KIR3DL3 gene), variant 44b TM3.
AJ938059 - Homo sapiens mRNA for killer cell immunoglobulin-like receptor (KIR3DL3 gene), variant 44b TM4.
AJ938060 - Homo sapiens mRNA for killer cell immunoglobulin-like receptor (KIR3DL3 gene), variant 1 TM1.
AJ938061 - Homo sapiens mRNA for killer cell immunoglobulin-like receptor (KIR3DL3 gene), variant 1 TM2.
AJ938062 - Homo sapiens mRNA for killer cell immunoglobulin-like receptor (KIR3DL3 gene), variant 1 TM3.
AJ938063 - Homo sapiens mRNA for killer cell immunoglobulin-like receptor (KIR3DL3 gene), variant 2.
AJ938064 - Homo sapiens mRNA for killer cell immunoglobulin-like receptor (KIR3DL3 gene), variant 3.
AJ938065 - Homo sapiens mRNA for killer cell immunoglobulin-like receptor (KIR3DL3 gene), variant 4.
AJ938066 - Homo sapiens mRNA for killer cell immunoglobulin-like receptor (KIR3DL3 gene), variant 5.
HQ447501 - Synthetic construct Homo sapiens clone IMAGE:100070837; CCSB013921_01 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 (KIR2DL1) gene, encodes complete protein.
KJ901542 - Synthetic construct Homo sapiens clone ccsbBroadEn_10936 KIR2DL1 gene, encodes complete protein.
LS974089 - Homo sapiens mRNA for KIR3DL3 protein (KIR3DL3 gene), isolate 72, allele Del594bp_(ex4+5)_hKIR3DL3.
LT963640 - Homo sapiens mRNA for KIR2DL protein (KIR2DL1/3DL2 gene), isolate 01, 04, allele KIR2DL1/3DL2.
LS974115 - Homo sapiens mRNA for KIR2DL1 protein (KIR2DL1 gene), isolate 10, 38, allele Ins57bp_(Cry)_hKIR2DL1_00302.
AY789056 - Homo sapiens natural killer cell inhibitory receptor (KIR2DL1) mRNA, KIR2DL1*00302 allele, complete cds.
KJ699235 - Homo sapiens KIR2DL1 mRNA, complete cds.
U24078 - Human p58 natural killer cell receptor precursor mRNA, clone 47.11, complete cds.
AY366240 - Homo sapiens natural killer cell inhibitory receptor (KIR2DL1) mRNA, KIR2DL1*0040102 allele, complete cds.
AY366241 - Homo sapiens natural killer cell inhibitory receptor (KIR2DL1) mRNA, KIR2DL1*006 allele, complete cds.
AY789055 - Homo sapiens natural killer cell inhibitory receptor (KIR2DL1) mRNA, KIR2DL1*002 allele, complete cds.
AF285431 - Homo sapiens clone KIR2DL1v2 killer-cell Ig-like receptor mRNA, complete cds.
AY366237 - Homo sapiens natural killer cell inhibitory receptor (KIR2DL1) mRNA, KIR2DL1*00302 allele, complete cds.
L41267 - Homo sapiens natural killer-associated transcript 1 (NKAT1) mRNA, complete cds.
AY388471 - Homo sapiens natural killer cell Ig-like receptor KIR2DL1 (KIR2DL1) mRNA, KIR2DL1*00401 allele, complete cds.
AY366239 - Homo sapiens natural killer cell inhibitory receptor (KIR2DL1) mRNA, KIR2DL1*00303 allele, complete cds.
BC069344 - Homo sapiens killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1, mRNA (cDNA clone MGC:97081 IMAGE:7262296), complete cds.
U24076 - Human p58 natural killer cell receptor precursor mRNA, clone cl-42, complete cds.
AF022045 - Homo sapiens natural killer cell receptor KIR2DL1 variant mRNA, complete cds.
U50546 - Human natural killer-associated transcript 2a protein (NKAT2a-delta-Ig2) mRNA, complete cds.
CU686761 - Synthetic construct Homo sapiens gateway clone IMAGE:100022675 5' read KIR2DL1 mRNA.
HQ447501 - Synthetic construct Homo sapiens clone IMAGE:100070837; CCSB013921_01 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 (KIR2DL1) gene, encodes complete protein.
KJ901542 - Synthetic construct Homo sapiens clone ccsbBroadEn_10936 KIR2DL1 gene, encodes complete protein.
LS974078 - Homo sapiens mRNA for KIR2DL1 protein (KIR2DL1 gene), isolate 82, allele Del51bp_(ex6)_hKIR2DL1_00401.
LS974099 - Homo sapiens mRNA for KIR2DL1 protein (KIR2DL1 gene), isolate 00, 04, allele Ins49bp_(3ss)_hKIR2DL1_00201.
LS974111 - Homo sapiens mRNA for KIR2DL1 protein (KIR2DL1 gene), isolate 00, 02, allele Ins78p_(Cry)_hKIR2DL1_00201.
LS974115 - Homo sapiens mRNA for KIR2DL1 protein (KIR2DL1 gene), isolate 10, 38, allele Ins57bp_(Cry)_hKIR2DL1_00302.
AY789056 - Homo sapiens natural killer cell inhibitory receptor (KIR2DL1) mRNA, KIR2DL1*00302 allele, complete cds.
AY366238 - Homo sapiens natural killer cell inhibitory receptor (KIR2DL1) mRNA, KIR2DL1*00302 allele, partial cds.
FN395076 - Homo sapiens partial mRNA for killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5 (KIR2DS5 gene), clone MHH-JZE-E9.
AF285432 - Homo sapiens clone KIR2DL1v3 killer-cell Ig-like receptor mRNA, partial cds.
JD036258 - Sequence 17282 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04612 - Antigen processing and presentation
hsa04650 - Natural killer cell mediated cytotoxicity

-  Other Names for This Gene
  Alternate Gene Symbols: AJ630586, uc061csz.1
UCSC ID: uc061csz.1
RefSeq Accession: NM_014513

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.