ID:HUMMR_HUMAN DESCRIPTION: RecName: Full=Protein MGARP; AltName: Full=Corneal endothelium-specific protein 1; Short=CESP-1; AltName: Full=Hypoxia up-regulated mitochondrial movement regulator protein; AltName: Full=Mitochondria-localized glutamic acid-rich protein; AltName: Full=Ovary-specific acidic protein; FUNCTION: Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity). SUBUNIT: Interacts with RHOT1/Miro-1, TRAK1/OIP106 and TRAK2/GRIF1 (By similarity). Interacts with RHOT2/Miro-2. SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). Mitochondrion. Mitochondrion outer membrane; Single- pass type IV membrane protein; Cytoplasmic side (By similarity). Note=Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion (By similarity). TISSUE SPECIFICITY: Expressed in the brain, adrenal gland and corneal endothelium (CE). Expressed in steroid-producing cells of the ovary and testis (at protein level). Expressed in steroid- producing cells of the ovary and testis. Weakly expressed in placenta. Expressed in corneal endothelial cells.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TDB4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006626 protein targeting to mitochondrion GO:0008089 anterograde axonal transport GO:0008090 retrograde axonal transport GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0019896 axonal transport of mitochondrion GO:0071383 cellular response to steroid hormone stimulus GO:0071456 cellular response to hypoxia GO:0097211 cellular response to gonadotropin-releasing hormone