Human Gene SOCS6 (ENST00000397942.4) Description and Page Index
Description: Homo sapiens suppressor of cytokine signaling 6 (SOCS6), mRNA. (from RefSeq NM_004232) RefSeq Summary (NM_004232): The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.214235.1, SRR1660807.205991.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000397942.4/ ENSP00000381034.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Gencode Transcript: ENST00000397942.4 Gencode Gene: ENSG00000170677.6 Transcript (Including UTRs) Position: hg38 chr18:70,289,045-70,330,199 Size: 41,155 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr18:70,324,669-70,326,276 Size: 1,608 Coding Exon Count: 1
ID:SOCS6_HUMAN DESCRIPTION: RecName: Full=Suppressor of cytokine signaling 6; Short=SOCS-6; AltName: Full=Cytokine-inducible SH2 protein 4; Short=CIS-4; AltName: Full=Suppressor of cytokine signaling 4; Short=SOCS-4; FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with RBCK1. Interacts with phosphorylated IRS4 (By similarity). Interacts with PIM3 (By similarity). Interacts with KIT (phosphorylated). DOMAIN: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). SIMILARITY: Contains 1 SH2 domain. SIMILARITY: Contains 1 SOCS box domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14544
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.