Human Gene MED13 (ENST00000397786.7) Description and Page Index
  Description: Homo sapiens mediator complex subunit 13 (MED13), mRNA. (from RefSeq NM_005121)
RefSeq Summary (NM_005121): This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF117754.1, BC140891.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000397786.7/ ENSP00000380888.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000397786.7
Gencode Gene: ENSG00000108510.10
Transcript (Including UTRs)
   Position: hg38 chr17:61,942,605-62,065,278 Size: 122,674 Total Exon Count: 30 Strand: -
Coding Region
   Position: hg38 chr17:61,946,468-62,065,205 Size: 118,738 Coding Exon Count: 30 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:61,942,605-62,065,278)mRNA (may differ from genome)Protein (2174 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGImyGene2neXtProtOMIM
PubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: MED13_HUMAN
DESCRIPTION: RecName: Full=Mediator of RNA polymerase II transcription subunit 13; AltName: Full=Activator-recruited cofactor 250 kDa component; Short=ARC250; AltName: Full=Mediator complex subunit 13; AltName: Full=Thyroid hormone receptor-associated protein 1; AltName: Full=Thyroid hormone receptor-associated protein complex 240 kDa component; Short=Trap240; AltName: Full=Vitamin D3 receptor-interacting protein complex component DRIP250; Short=DRIP250;
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
SUBUNIT: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: Belongs to the Mediator complex subunit 13 family.
SEQUENCE CAUTION: Sequence=AAD22032.1; Type=Frameshift; Positions=Several;

-  MalaCards Disease Associations
  MalaCards Gene Search: MED13
Diseases sorted by gene-association score: med23 (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.89 RPKM in Testis
Total median expression: 297.90 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -27.6073-0.378 Picture PostScript Text
3' UTR -874.903863-0.226 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009401 - Mediator_Med13
IPR021643 - Mediator_Med13_N_met/fun

Pfam Domains:
PF06333 - Mediator complex subunit 13 C-terminal
PF11597 - Mediator complex subunit 13 N-terminal

ModBase Predicted Comparative 3D Structure on Q9UHV7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0038023 signaling receptor activity
GO:0042809 vitamin D receptor binding
GO:0046966 thyroid hormone receptor binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
GO:0042632 cholesterol homeostasis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070328 triglyceride homeostasis
GO:1904168 negative regulation of thyroid hormone receptor activity

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0016592 mediator complex


-  Descriptions from all associated GenBank mRNAs
  LF209244 - JP 2014500723-A/16747: Polycomb-Associated Non-Coding RNAs.
MA444821 - JP 2018138019-A/16747: Polycomb-Associated Non-Coding RNAs.
AB011165 - Homo sapiens mRNA for KIAA0593 protein, partial cds.
AF117754 - Homo sapiens thyroid hormone receptor-associated protein complex component TRAP240 mRNA, complete cds.
BC140891 - Homo sapiens mediator complex subunit 13, mRNA (cDNA clone MGC:176568 IMAGE:9021759), complete cds.
AK054894 - Homo sapiens cDNA FLJ30332 fis, clone BRACE2007254.
LF327116 - JP 2014500723-A/134619: Polycomb-Associated Non-Coding RNAs.
MA562693 - JP 2018138019-A/134619: Polycomb-Associated Non-Coding RNAs.
LF327117 - JP 2014500723-A/134620: Polycomb-Associated Non-Coding RNAs.
MA562694 - JP 2018138019-A/134620: Polycomb-Associated Non-Coding RNAs.
LF327118 - JP 2014500723-A/134621: Polycomb-Associated Non-Coding RNAs.
MA562695 - JP 2018138019-A/134621: Polycomb-Associated Non-Coding RNAs.
LF327119 - JP 2014500723-A/134622: Polycomb-Associated Non-Coding RNAs.
MA562696 - JP 2018138019-A/134622: Polycomb-Associated Non-Coding RNAs.
LF327120 - JP 2014500723-A/134623: Polycomb-Associated Non-Coding RNAs.
MA562697 - JP 2018138019-A/134623: Polycomb-Associated Non-Coding RNAs.
LF327121 - JP 2014500723-A/134624: Polycomb-Associated Non-Coding RNAs.
MA562698 - JP 2018138019-A/134624: Polycomb-Associated Non-Coding RNAs.
BC044258 - Homo sapiens cDNA clone IMAGE:6068796, containing frame-shift errors.
LF327122 - JP 2014500723-A/134625: Polycomb-Associated Non-Coding RNAs.
MA562699 - JP 2018138019-A/134625: Polycomb-Associated Non-Coding RNAs.
JD285364 - Sequence 266388 from Patent EP1572962.
LF327123 - JP 2014500723-A/134626: Polycomb-Associated Non-Coding RNAs.
MA562700 - JP 2018138019-A/134626: Polycomb-Associated Non-Coding RNAs.
FW592347 - JP 2010535246-A/6: MICRO-RNAS THAT CONTROL MYOSIN EXPRESSION AND MYOFIBER IDENTITY.
FW592386 - JP 2010535247-A/6: A MICRO-RNA FAMILY THAT MODULATES FIBROSIS AND USES THEREOF.
HI550641 - Sequence 6 from Patent EP2182969.
HV308646 - JP 2009545615-A/6: IDENTIFICATION OF A MICRO-RNA THAT ACTIVATES EXPRESSION OF BETA-MYOSIN HEAVY CHAIN.
HW805241 - JP 2015013864-A/6: MICRO-RNAS THAT CONTROL MYOSIN EXPRESSION AND MYOFIBER IDENTITY.
HW827727 - JP 2014001243-A/6: IDENTIFICATION OF A MICRO-RNA THAT ACTIVATES EXPRESSION OF BETA-MYOSIN HEAVY CHAIN.
HZ427131 - JP 2014198728-A/6: A MICRO-RNA FAMILY THAT MODULATES FIBROSIS AND USES THEREOF.
JB250760 - Sequence 6 from Patent EP2434017.
LG064769 - KR 1020150053815-A/6: A Micro-RNA Family That Modulates Fibrosis and Uses Thereof.
DI486456 - KR 1020140130562-A/38: Method for regulating muscle cell proliferation and differentiation, treating muscle cell, controlling gene expression which are using MICRORNAS, and derepession vector of MICRORNAS molecule, Kit and Myocyt using them.
DM371786 - MICRORNAS THAT REGULATE MUSCLE CELL PROLIFERATION AND DIFFERENTIATION.
HW530369 - JP 2014094943-A/38: MICRORNAS THAT REGULATE MUSCLE CELL PROLIFERATION AND DIFFERENTIATION.
HW588595 - JP 2013126996-A/38: MICRORNAS THAT REGULATE MUSCLE CELL PROLIFERATION AND DIFFERENTIATION.
JC031759 - Sequence 38 from Patent EP2671949.
JC218697 - Sequence 38 from Patent EP2497827.
JD357426 - Sequence 338450 from Patent EP1572962.
LF327124 - JP 2014500723-A/134627: Polycomb-Associated Non-Coding RNAs.
MA562701 - JP 2018138019-A/134627: Polycomb-Associated Non-Coding RNAs.
JD039385 - Sequence 20409 from Patent EP1572962.
LF327125 - JP 2014500723-A/134628: Polycomb-Associated Non-Coding RNAs.
MA562702 - JP 2018138019-A/134628: Polycomb-Associated Non-Coding RNAs.
JD328058 - Sequence 309082 from Patent EP1572962.
LF327127 - JP 2014500723-A/134630: Polycomb-Associated Non-Coding RNAs.
MA562704 - JP 2018138019-A/134630: Polycomb-Associated Non-Coding RNAs.
LF327129 - JP 2014500723-A/134632: Polycomb-Associated Non-Coding RNAs.
MA562706 - JP 2018138019-A/134632: Polycomb-Associated Non-Coding RNAs.
LF327130 - JP 2014500723-A/134633: Polycomb-Associated Non-Coding RNAs.
MA562707 - JP 2018138019-A/134633: Polycomb-Associated Non-Coding RNAs.
LF327131 - JP 2014500723-A/134634: Polycomb-Associated Non-Coding RNAs.
MA562708 - JP 2018138019-A/134634: Polycomb-Associated Non-Coding RNAs.
LF327132 - JP 2014500723-A/134635: Polycomb-Associated Non-Coding RNAs.
MA562709 - JP 2018138019-A/134635: Polycomb-Associated Non-Coding RNAs.
LF327133 - JP 2014500723-A/134636: Polycomb-Associated Non-Coding RNAs.
MA562710 - JP 2018138019-A/134636: Polycomb-Associated Non-Coding RNAs.
LF327135 - JP 2014500723-A/134638: Polycomb-Associated Non-Coding RNAs.
MA562712 - JP 2018138019-A/134638: Polycomb-Associated Non-Coding RNAs.
LF327137 - JP 2014500723-A/134640: Polycomb-Associated Non-Coding RNAs.
MA562714 - JP 2018138019-A/134640: Polycomb-Associated Non-Coding RNAs.
LF327138 - JP 2014500723-A/134641: Polycomb-Associated Non-Coding RNAs.
MA562715 - JP 2018138019-A/134641: Polycomb-Associated Non-Coding RNAs.
LF327139 - JP 2014500723-A/134642: Polycomb-Associated Non-Coding RNAs.
MA562716 - JP 2018138019-A/134642: Polycomb-Associated Non-Coding RNAs.
LF327140 - JP 2014500723-A/134643: Polycomb-Associated Non-Coding RNAs.
MA562717 - JP 2018138019-A/134643: Polycomb-Associated Non-Coding RNAs.
LF327141 - JP 2014500723-A/134644: Polycomb-Associated Non-Coding RNAs.
MA562718 - JP 2018138019-A/134644: Polycomb-Associated Non-Coding RNAs.
AF151055 - Homo sapiens HSPC221 mRNA, complete cds.
LF327146 - JP 2014500723-A/134649: Polycomb-Associated Non-Coding RNAs.
MA562723 - JP 2018138019-A/134649: Polycomb-Associated Non-Coding RNAs.
AK124099 - Homo sapiens cDNA FLJ42105 fis, clone TESOP2007674.
LF327147 - JP 2014500723-A/134650: Polycomb-Associated Non-Coding RNAs.
MA562724 - JP 2018138019-A/134650: Polycomb-Associated Non-Coding RNAs.
LF327153 - JP 2014500723-A/134656: Polycomb-Associated Non-Coding RNAs.
MA562730 - JP 2018138019-A/134656: Polycomb-Associated Non-Coding RNAs.
JD139432 - Sequence 120456 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UHV7 (Reactome details) participates in the following event(s):

R-HSA-212352 Formation of ARC coactivator complex
R-HSA-212380 Formation of TRAP coactivator complex
R-HSA-212432 Formation of DRIP coactivator complex
R-HSA-381309 PPARG:RXRA heterodimer binds to fatty acid-like ligands
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-1266738 Developmental Biology
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: ARC250, B2RU05, KIAA0593, MED13_HUMAN, NM_005121, O60334, Q9UHV7, THRAP1, TRAP240, uc002izo.1, uc002izo.2, uc002izo.3, uc002izo.4
UCSC ID: uc002izo.4
RefSeq Accession: NM_005121
Protein: Q9UHV7 (aka MED13_HUMAN)
CCDS: CCDS42366.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.