Human Gene LYPD1 (ENST00000397463.3) Description and Page Index
Description: Homo sapiens LY6/PLAUR domain containing 1 (LYPD1), transcript variant 1, mRNA. (from RefSeq NM_144586)
Gencode Transcript: ENST00000397463.3
Gencode Gene: ENSG00000150551.11
Transcript (Including UTRs)
Position: hg38 chr2:132,643,286-132,670,205 Size: 26,920 Total Exon Count: 3 Strand: -
Position: hg38 chr2:132,646,045-132,669,932 Size: 23,888 Coding Exon Count: 3
Data last updated: 2019-09-04
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Ly6/PLAUR domain-containing protein 1; AltName: Full=Putative HeLa tumor suppressor; Short=PHTS; Flags: Precursor;
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (Potential). SIMILARITY: Contains 1 UPAR/Ly6 domain. SEQUENCE CAUTION: Sequence=BAC11647.1; Type=Frameshift; Positions=136;
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR016054 - LY6_UPA_recep-like
ModBase Predicted Comparative 3D Structure on Q8N2G4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK130005 - Homo sapiens cDNA FLJ26495 fis, clone KDN06425. BC040046 - Homo sapiens LY6/PLAUR domain containing 1, mRNA (cDNA clone MGC:50792 IMAGE:5727798), complete cds. BC011449 - Homo sapiens cDNA clone IMAGE:4026092, partial cds. AK075487 - Homo sapiens cDNA PSEC0181 fis, clone OVARC1001499. AK094501 - Homo sapiens cDNA FLJ37182 fis, clone BRALZ2001350, weakly similar to Homo sapiens Gz-selective GTPase-activating protein (RGS20) mRNA. AK123029 - Homo sapiens cDNA FLJ41033 fis, clone FCBBF3009888, weakly similar to Homo sapiens prostate stem cell antigen (PSCA) mRNA. JD155809 - Sequence 136833 from Patent EP1572962. JD510116 - Sequence 491140 from Patent EP1572962. JD349886 - Sequence 330910 from Patent EP1572962. JD185302 - Sequence 166326 from Patent EP1572962. JD380900 - Sequence 361924 from Patent EP1572962. JD179312 - Sequence 160336 from Patent EP1572962. AY358628 - Homo sapiens clone DNA119474 PSCA Hlog (UNQ3079) mRNA, complete cds. AK309668 - Homo sapiens cDNA, FLJ99709. AK309849 - Homo sapiens cDNA, FLJ99890. BC017318 - Homo sapiens LY6/PLAUR domain containing 1, mRNA (cDNA clone MGC:29643 IMAGE:3641660), complete cds. JD549865 - Sequence 530889 from Patent EP1572962. JD561982 - Sequence 543006 from Patent EP1572962. JD405693 - Sequence 386717 from Patent EP1572962. JD044391 - Sequence 25415 from Patent EP1572962. KJ895313 - Synthetic construct Homo sapiens clone ccsbBroadEn_04707 LYPD1 gene, encodes complete protein. JD028163 - Sequence 9187 from Patent EP1572962. JD021004 - Sequence 2028 from Patent EP1572962. JD141112 - Sequence 122136 from Patent EP1572962. JD186990 - Sequence 168014 from Patent EP1572962. JD115020 - Sequence 96044 from Patent EP1572962. JD399312 - Sequence 380336 from Patent EP1572962. JD406587 - Sequence 387611 from Patent EP1572962. JD125557 - Sequence 106581 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO) Protein Q8N2G4 ( Reactome details) participates in the following event(s): R-HSA-8940388 GPLD1 hydrolyses GPI-anchors from proteins
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins
Other Names for This Gene
Alternate Gene Symbols: LYPD1_HUMAN, LYPDC1, NM_144586, PSEC0181, Q6ZP52, Q6ZWI4, Q8N2G4, Q96AC2, uc002ttn.1, uc002ttn.2, uc002ttn.3, uc002ttn.4, uc002ttn.5, UNQ3079/PRO9917 UCSC ID: uc002ttn.5 RefSeq Accession: NM_144586
(aka LYPD1_HUMAN) Q8N2G4
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.