Human Gene LYPD1 (ENST00000397463.3) Description and Page Index
  Description: Homo sapiens LY6/PLAUR domain containing 1 (LYPD1), transcript variant 1, mRNA. (from RefSeq NM_144586)
Gencode Transcript: ENST00000397463.3
Gencode Gene: ENSG00000150551.11
Transcript (Including UTRs)
   Position: hg38 chr2:132,643,286-132,670,205 Size: 26,920 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chr2:132,646,045-132,669,932 Size: 23,888 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:132,643,286-132,670,205)mRNA (may differ from genome)Protein (141 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsHGNCHPRD
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Ly6/PLAUR domain-containing protein 1; AltName: Full=Putative HeLa tumor suppressor; Short=PHTS; Flags: Precursor;
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (Potential).
SIMILARITY: Contains 1 UPAR/Ly6 domain.
SEQUENCE CAUTION: Sequence=BAC11647.1; Type=Frameshift; Positions=136;

-  MalaCards Disease Associations
  MalaCards Gene Search: LYPD1
Diseases sorted by gene-association score: cowden disease (1), renal cell carcinoma, papillary (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.52 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 92.92 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -141.20273-0.517 Picture PostScript Text
3' UTR -844.172759-0.306 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016054 - LY6_UPA_recep-like

ModBase Predicted Comparative 3D Structure on Q8N2G4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0030550 acetylcholine receptor inhibitor activity
GO:0033130 acetylcholine receptor binding

Biological Process:
GO:0001662 behavioral fear response
GO:0001775 cell activation
GO:0007271 synaptic transmission, cholinergic
GO:0035094 response to nicotine
GO:0095500 acetylcholine receptor signaling pathway
GO:1903077 negative regulation of protein localization to plasma membrane
GO:2000272 negative regulation of receptor activity

Cellular Component:
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane

-  Descriptions from all associated GenBank mRNAs
  AK130005 - Homo sapiens cDNA FLJ26495 fis, clone KDN06425.
BC040046 - Homo sapiens LY6/PLAUR domain containing 1, mRNA (cDNA clone MGC:50792 IMAGE:5727798), complete cds.
BC011449 - Homo sapiens cDNA clone IMAGE:4026092, partial cds.
AK075487 - Homo sapiens cDNA PSEC0181 fis, clone OVARC1001499.
AK094501 - Homo sapiens cDNA FLJ37182 fis, clone BRALZ2001350, weakly similar to Homo sapiens Gz-selective GTPase-activating protein (RGS20) mRNA.
AK123029 - Homo sapiens cDNA FLJ41033 fis, clone FCBBF3009888, weakly similar to Homo sapiens prostate stem cell antigen (PSCA) mRNA.
JD155809 - Sequence 136833 from Patent EP1572962.
JD510116 - Sequence 491140 from Patent EP1572962.
JD349886 - Sequence 330910 from Patent EP1572962.
JD185302 - Sequence 166326 from Patent EP1572962.
JD380900 - Sequence 361924 from Patent EP1572962.
JD179312 - Sequence 160336 from Patent EP1572962.
AY358628 - Homo sapiens clone DNA119474 PSCA Hlog (UNQ3079) mRNA, complete cds.
AK309668 - Homo sapiens cDNA, FLJ99709.
AK309849 - Homo sapiens cDNA, FLJ99890.
BC017318 - Homo sapiens LY6/PLAUR domain containing 1, mRNA (cDNA clone MGC:29643 IMAGE:3641660), complete cds.
JD549865 - Sequence 530889 from Patent EP1572962.
JD561982 - Sequence 543006 from Patent EP1572962.
JD405693 - Sequence 386717 from Patent EP1572962.
JD044391 - Sequence 25415 from Patent EP1572962.
KJ895313 - Synthetic construct Homo sapiens clone ccsbBroadEn_04707 LYPD1 gene, encodes complete protein.
JD028163 - Sequence 9187 from Patent EP1572962.
JD021004 - Sequence 2028 from Patent EP1572962.
JD141112 - Sequence 122136 from Patent EP1572962.
JD186990 - Sequence 168014 from Patent EP1572962.
JD115020 - Sequence 96044 from Patent EP1572962.
JD399312 - Sequence 380336 from Patent EP1572962.
JD406587 - Sequence 387611 from Patent EP1572962.
JD125557 - Sequence 106581 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8N2G4 (Reactome details) participates in the following event(s):

R-HSA-8940388 GPLD1 hydrolyses GPI-anchors from proteins
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: LYPD1_HUMAN, LYPDC1, NM_144586, PSEC0181, Q6ZP52, Q6ZWI4, Q8N2G4, Q96AC2, uc002ttn.1, uc002ttn.2, uc002ttn.3, uc002ttn.4, uc002ttn.5, UNQ3079/PRO9917
UCSC ID: uc002ttn.5
RefSeq Accession: NM_144586
Protein: Q8N2G4 (aka LYPD1_HUMAN)
CCDS: CCDS42759.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.