Human Gene RBAK (ENST00000396912.2) Description and Page Index
Description: Homo sapiens RB associated KRAB zinc finger (RBAK), transcript variant 1, mRNA. (from RefSeq NM_021163) RefSeq Summary (NM_021163): This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011]. Gencode Transcript: ENST00000396912.2 Gencode Gene: ENSG00000146587.18 Transcript (Including UTRs) Position: hg38 chr7:5,045,860-5,069,487 Size: 23,628 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr7:5,048,077-5,065,601 Size: 17,525 Coding Exon Count: 4
ID:RBAK_HUMAN DESCRIPTION: RecName: Full=RB-associated KRAB zinc finger protein; AltName: Full=RB-associated KRAB repressor; Short=hRBaK; AltName: Full=Zinc finger protein 769; FUNCTION: May repress E2F-dependent transcription. May promote AR- dependent transcription. SUBUNIT: Interacts with AR and RB1. May also interact with other nuclear hormone receptors such as NR3C1/GR. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in bone, brain, heart, kidney, liver, lung, pancreas and placenta. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 16 C2H2-type zinc fingers. SIMILARITY: Contains 1 KRAB domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NYW8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0045892 negative regulation of transcription, DNA-templated