Human Gene RBAK (ENST00000396912.2) Description and Page Index
  Description: Homo sapiens RB associated KRAB zinc finger (RBAK), transcript variant 1, mRNA. (from RefSeq NM_021163)
RefSeq Summary (NM_021163): This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011].
Gencode Transcript: ENST00000396912.2
Gencode Gene: ENSG00000146587.18
Transcript (Including UTRs)
   Position: hg38 chr7:5,045,860-5,069,487 Size: 23,628 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr7:5,048,077-5,065,601 Size: 17,525 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:5,045,860-5,069,487)mRNA (may differ from genome)Protein (714 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: RBAK_HUMAN
DESCRIPTION: RecName: Full=RB-associated KRAB zinc finger protein; AltName: Full=RB-associated KRAB repressor; Short=hRBaK; AltName: Full=Zinc finger protein 769;
FUNCTION: May repress E2F-dependent transcription. May promote AR- dependent transcription.
SUBUNIT: Interacts with AR and RB1. May also interact with other nuclear hormone receptors such as NR3C1/GR.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed in bone, brain, heart, kidney, liver, lung, pancreas and placenta.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 16 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: RBAK
Diseases sorted by gene-association score: familial hyperaldosteronism (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -311.70581-0.536 Picture PostScript Text
3' UTR -883.003886-0.227 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF01352 - KRAB box

ModBase Predicted Comparative 3D Structure on Q9NYW8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0045892 negative regulation of transcription, DNA-templated

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm


-  Descriptions from all associated GenBank mRNAs
  BC071642 - Homo sapiens cDNA clone IMAGE:4422592, **** WARNING: chimeric clone ****.
AK293069 - Homo sapiens cDNA FLJ75216 complete cds, highly similar to Homo sapiens RB-associated KRAB repressor (RBAK) mRNA.
LF207005 - JP 2014500723-A/14508: Polycomb-Associated Non-Coding RNAs.
MA442582 - JP 2018138019-A/14508: Polycomb-Associated Non-Coding RNAs.
LF213897 - JP 2014500723-A/21400: Polycomb-Associated Non-Coding RNAs.
MA449474 - JP 2018138019-A/21400: Polycomb-Associated Non-Coding RNAs.
JD078514 - Sequence 59538 from Patent EP1572962.
AF226869 - Homo sapiens RB-associated KRAB repressor (RBAK) mRNA, complete cds.
JD192089 - Sequence 173113 from Patent EP1572962.
JD195935 - Sequence 176959 from Patent EP1572962.
JD229608 - Sequence 210632 from Patent EP1572962.
JD461879 - Sequence 442903 from Patent EP1572962.
JD407322 - Sequence 388346 from Patent EP1572962.
JD216872 - Sequence 197896 from Patent EP1572962.
JD458839 - Sequence 439863 from Patent EP1572962.
JD394617 - Sequence 375641 from Patent EP1572962.
JD203642 - Sequence 184666 from Patent EP1572962.
JD173602 - Sequence 154626 from Patent EP1572962.
JD057826 - Sequence 38850 from Patent EP1572962.
JD255600 - Sequence 236624 from Patent EP1572962.
JD407144 - Sequence 388168 from Patent EP1572962.
JD160336 - Sequence 141360 from Patent EP1572962.
BC136675 - Homo sapiens RB-associated KRAB zinc finger, mRNA (cDNA clone MGC:168288 IMAGE:9020665), complete cds.
BC136676 - Homo sapiens RB-associated KRAB zinc finger, mRNA (cDNA clone MGC:168289 IMAGE:9020666), complete cds.
JD039292 - Sequence 20316 from Patent EP1572962.
JD307272 - Sequence 288296 from Patent EP1572962.
JD190361 - Sequence 171385 from Patent EP1572962.
JD405792 - Sequence 386816 from Patent EP1572962.
JD256960 - Sequence 237984 from Patent EP1572962.
JD069454 - Sequence 50478 from Patent EP1572962.
JD069453 - Sequence 50477 from Patent EP1572962.
JD474413 - Sequence 455437 from Patent EP1572962.
JD374062 - Sequence 355086 from Patent EP1572962.
JD077897 - Sequence 58921 from Patent EP1572962.
JD239548 - Sequence 220572 from Patent EP1572962.
AB384855 - Synthetic construct DNA, clone: pF1KB3788, Homo sapiens RBAK gene for RB-associated KRAB repressor, complete cds, without stop codon, in Flexi system.
KJ899372 - Synthetic construct Homo sapiens clone ccsbBroadEn_08766 RBAK gene, encodes complete protein.
JD473045 - Sequence 454069 from Patent EP1572962.
JD546863 - Sequence 527887 from Patent EP1572962.
JD357437 - Sequence 338461 from Patent EP1572962.
LF360106 - JP 2014500723-A/167609: Polycomb-Associated Non-Coding RNAs.
MA595683 - JP 2018138019-A/167609: Polycomb-Associated Non-Coding RNAs.
LF360105 - JP 2014500723-A/167608: Polycomb-Associated Non-Coding RNAs.
MA595682 - JP 2018138019-A/167608: Polycomb-Associated Non-Coding RNAs.
LF360104 - JP 2014500723-A/167607: Polycomb-Associated Non-Coding RNAs.
MA595681 - JP 2018138019-A/167607: Polycomb-Associated Non-Coding RNAs.
JD142852 - Sequence 123876 from Patent EP1572962.
LF360103 - JP 2014500723-A/167606: Polycomb-Associated Non-Coding RNAs.
MA595680 - JP 2018138019-A/167606: Polycomb-Associated Non-Coding RNAs.
JD196677 - Sequence 177701 from Patent EP1572962.
LF360102 - JP 2014500723-A/167605: Polycomb-Associated Non-Coding RNAs.
MA595679 - JP 2018138019-A/167605: Polycomb-Associated Non-Coding RNAs.
JD279988 - Sequence 261012 from Patent EP1572962.
JD331974 - Sequence 312998 from Patent EP1572962.
JD093642 - Sequence 74666 from Patent EP1572962.
JD082246 - Sequence 63270 from Patent EP1572962.
JD348509 - Sequence 329533 from Patent EP1572962.
JD362890 - Sequence 343914 from Patent EP1572962.
JD065493 - Sequence 46517 from Patent EP1572962.
JD305544 - Sequence 286568 from Patent EP1572962.
JD083566 - Sequence 64590 from Patent EP1572962.
JD083562 - Sequence 64586 from Patent EP1572962.
JD052005 - Sequence 33029 from Patent EP1572962.
JD362882 - Sequence 343906 from Patent EP1572962.
AK093275 - Homo sapiens cDNA FLJ35956 fis, clone TESTI2012289.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NDF2, A8KAK4, B2RN44, B9EGS1, NM_021163, Q9NYW8, RBAK_HUMAN, uc003sns.1, uc003sns.2, ZNF769
UCSC ID: uc003sns.2
RefSeq Accession: NM_021163
Protein: Q9NYW8 (aka RBAK_HUMAN)
CCDS: CCDS5337.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.