Human Gene ZNF665 (ENST00000396424.5) Description and Page Index
  Description: Homo sapiens zinc finger protein 665 (ZNF665), transcript variant 4, mRNA. (from RefSeq NM_024733)
Gencode Transcript: ENST00000396424.5
Gencode Gene: ENSG00000197497.11
Transcript (Including UTRs)
   Position: hg38 chr19:53,162,424-53,193,358 Size: 30,935 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr19:53,164,453-53,182,898 Size: 18,446 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:53,162,424-53,193,358)mRNA (may differ from genome)Protein (678 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 665; AltName: Full=Zinc finger protein 160-like;
FUNCTION: May be involved in transcriptional regulation.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 18 C2H2-type zinc fingers.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.42 RPKM in Ovary
Total median expression: 21.99 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.8092-0.172 Picture PostScript Text
3' UTR -893.002029-0.440 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

ModBase Predicted Comparative 3D Structure on Q9H7R5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  AL832507 - Homo sapiens mRNA; cDNA DKFZp686K1252 (from clone DKFZp686K1252).
JD472451 - Sequence 453475 from Patent EP1572962.
JD472452 - Sequence 453476 from Patent EP1572962.
JD179121 - Sequence 160145 from Patent EP1572962.
JD421527 - Sequence 402551 from Patent EP1572962.
JD257046 - Sequence 238070 from Patent EP1572962.
JD199480 - Sequence 180504 from Patent EP1572962.
JD378242 - Sequence 359266 from Patent EP1572962.
JD247044 - Sequence 228068 from Patent EP1572962.
AK024407 - Homo sapiens cDNA FLJ14345 fis, clone THYRO1001189, weakly similar to ZINC FINGER PROTEIN 91.
JD447160 - Sequence 428184 from Patent EP1572962.
JD208567 - Sequence 189591 from Patent EP1572962.
JD488611 - Sequence 469635 from Patent EP1572962.
JD158718 - Sequence 139742 from Patent EP1572962.
JD522406 - Sequence 503430 from Patent EP1572962.
JD288972 - Sequence 269996 from Patent EP1572962.
JD540196 - Sequence 521220 from Patent EP1572962.
JD560107 - Sequence 541131 from Patent EP1572962.
JD341989 - Sequence 323013 from Patent EP1572962.
JD319921 - Sequence 300945 from Patent EP1572962.
JD319920 - Sequence 300944 from Patent EP1572962.
JD127923 - Sequence 108947 from Patent EP1572962.
AK291403 - Homo sapiens cDNA FLJ77550 complete cds, highly similar to Homo sapiens zinc finger protein 665 (ZNF665), mRNA.
JD314907 - Sequence 295931 from Patent EP1572962.
JD314876 - Sequence 295900 from Patent EP1572962.
JD314887 - Sequence 295911 from Patent EP1572962.
JD314886 - Sequence 295910 from Patent EP1572962.
JD314882 - Sequence 295906 from Patent EP1572962.
JD363986 - Sequence 345010 from Patent EP1572962.
AK096261 - Homo sapiens cDNA FLJ38942 fis, clone NT2NE2017259.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9H7R5 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A8K5T8, NM_024733, Q9H7R5, uc010eqm.1, uc010eqm.2, uc010eqm.3, ZFP160L, ZN665_HUMAN
UCSC ID: uc010eqm.3
RefSeq Accession: NM_024733
Protein: Q9H7R5 (aka ZN665_HUMAN)
CCDS: CCDS46169.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.