Human Gene CCNE2 (ENST00000396133.7) Description and Page Index
  Description: Belongs to the cyclin family. (from UniProt Q8WUE3)
RefSeq Summary (NM_057749): The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.199067.1, SRR1660807.186854.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000396133.7
Gencode Gene: ENSG00000175305.17
Transcript (Including UTRs)
   Position: hg38 chr8:94,881,614-94,895,254 Size: 13,641 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg38 chr8:94,881,746-94,894,221 Size: 12,476 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr8:94,881,614-94,895,254)mRNA (may differ from genome)Protein (374 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
MGIPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=CCNE2 protein; SubName: Full=Cyclin E2, isoform CRA_a; SubName: Full=G1/S-specific cyclin-E2;
SIMILARITY: Belongs to the cyclin family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D000082 Acetaminophen
  • D001564 Benzo(a)pyrene
  • D016572 Cyclosporine
  • D017239 Paclitaxel
  • D013749 Tetrachlorodibenzodioxin
  • C017947 sodium arsenite
  • C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)
  • C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.69 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 40.96 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.70104-0.420 Picture PostScript Text
3' UTR -21.60132-0.164 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013763 - Cyclin-like
IPR014400 - Cyclin_A/B/D/E
IPR004367 - Cyclin_C
IPR006671 - Cyclin_N

Pfam Domains:
PF02984 - Cyclin, C-terminal domain
PF00134 - Cyclin, N-terminal domain

ModBase Predicted Comparative 3D Structure on Q8WUE3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0000082 G1/S transition of mitotic cell cycle
GO:0051726 regulation of cell cycle

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  LF206390 - JP 2014500723-A/13893: Polycomb-Associated Non-Coding RNAs.
MA441967 - JP 2018138019-A/13893: Polycomb-Associated Non-Coding RNAs.
AF091433 - Homo sapiens cyclin E2 mRNA, complete cds.
BC007015 - Homo sapiens cyclin E2, mRNA (cDNA clone MGC:12348 IMAGE:3997513), complete cds.
CU675495 - Synthetic construct Homo sapiens gateway clone IMAGE:100022225 5' read CCNE2 mRNA.
AF102778 - Homo sapiens cyclin E2 mRNA, complete cds.
AF106690 - Homo sapiens cyclin E2 mRNA, complete cds.
AF112857 - Homo sapiens cyclin E2 splice variant 1 mRNA, complete cds.
KJ901946 - Synthetic construct Homo sapiens clone ccsbBroadEn_11340 CCNE2 gene, encodes complete protein.
AB590470 - Synthetic construct DNA, clone: pFN21AE1879, Homo sapiens CCNE2 gene for cyclin E2, without stop codon, in Flexi system.
BC020729 - Homo sapiens cyclin E2, mRNA (cDNA clone MGC:22538 IMAGE:4774554), complete cds.
DQ893494 - Synthetic construct clone IMAGE:100006124; FLH193678.01X; RZPDo839A1179D cyclin E2 (CCNE2) gene, encodes complete protein.
DQ896366 - Synthetic construct Homo sapiens clone IMAGE:100010826; FLH193674.01L; RZPDo839A1169D cyclin E2 (CCNE2) gene, encodes complete protein.
KJ901947 - Synthetic construct Homo sapiens clone ccsbBroadEn_11341 CCNE2 gene, encodes complete protein.
CU676668 - Synthetic construct Homo sapiens gateway clone IMAGE:100022270 5' read CCNE2 mRNA.
LF353855 - JP 2014500723-A/161358: Polycomb-Associated Non-Coding RNAs.
MA589432 - JP 2018138019-A/161358: Polycomb-Associated Non-Coding RNAs.
LF353854 - JP 2014500723-A/161357: Polycomb-Associated Non-Coding RNAs.
MA589431 - JP 2018138019-A/161357: Polycomb-Associated Non-Coding RNAs.
LF353853 - JP 2014500723-A/161356: Polycomb-Associated Non-Coding RNAs.
MA589430 - JP 2018138019-A/161356: Polycomb-Associated Non-Coding RNAs.
JD344924 - Sequence 325948 from Patent EP1572962.
JD477961 - Sequence 458985 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04110 - Cell cycle
hsa04114 - Oocyte meiosis
hsa04115 - p53 signaling pathway
hsa05200 - Pathways in cancer
hsa05215 - Prostate cancer
hsa05222 - Small cell lung cancer

-  Other Names for This Gene
  Alternate Gene Symbols: BC020729, hCG_15054, Q8WUE3, Q8WUE3_HUMAN, uc003yhd.1, uc003yhd.2, uc003yhd.3
UCSC ID: uc003yhd.3
RefSeq Accession: NM_057749
Protein: Q8WUE3

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.