Human Gene ZBTB25 (ENST00000394715.1) Description and Page Index
Description: Homo sapiens zinc finger and BTB domain containing 25 (ZBTB25), transcript variant 8, mRNA. (from RefSeq NM_001354686)
Gencode Transcript: ENST00000394715.1
Gencode Gene: ENSG00000089775.11
Transcript (Including UTRs)
Position: hg38 chr14:64,486,839-64,504,584 Size: 17,746 Total Exon Count: 6 Strand: -
Position: hg38 chr14:64,486,923-64,490,533 Size: 3,611 Coding Exon Count: 2
Data last updated: 2019-09-04
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger and BTB domain-containing protein 25; AltName: Full=Zinc finger protein 46; AltName: Full=Zinc finger protein KUP;
FUNCTION: May be involved in transcriptional regulation. INTERACTION: Q99750:MDFI; NbExp=2; IntAct=EBI-739899, EBI-724076; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed mainly in hematopoietic cells and testis. SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 2 C2H2-type zinc fingers.
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd
Pfam Domains: PF00651 - BTB/POZ domain
PF00096 - Zinc finger, C2H2 type
ModBase Predicted Comparative 3D Structure on P24278
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC014650 - Homo sapiens mRNA similar to zinc finger protein 46 (KUP) (cDNA clone IMAGE:4564508). BC035804 - Homo sapiens zinc finger and BTB domain containing 25, mRNA (cDNA clone MGC:46128 IMAGE:5745935), complete cds. AK098181 - Homo sapiens cDNA FLJ40862 fis, clone TRACH2018262, highly similar to Zinc finger and BTB domain-containing protein 25. AK313889 - Homo sapiens cDNA, FLJ94524. X16576 - Human KUP mRNA for protein with two zinc fingers. JF432133 - Synthetic construct Homo sapiens clone IMAGE:100073273 zinc finger and BTB domain containing 25 (ZBTB25) gene, encodes complete protein. KJ892409 - Synthetic construct Homo sapiens clone ccsbBroadEn_01803 ZBTB25 gene, encodes complete protein. EU446912 - Synthetic construct Homo sapiens clone IMAGE:100070220; IMAGE:100012121; FLH257364.01L zinc finger and BTB domain containing 25 (ZBTB25) gene, encodes complete protein. AB587459 - Synthetic construct DNA, clone: pF1KB8178, Homo sapiens ZBTB25 gene for zinc finger and BTB domain containing 25, without stop codon, in Flexi system. CU690202 - Synthetic construct Homo sapiens gateway clone IMAGE:100019384 5' read ZBTB25 mRNA.
Other Names for This Gene
Alternate Gene Symbols: B3KUX6, C14orf51, KUP, NM_001354686, P24278, Q8IYH9, uc001xhg.1, uc001xhg.2, uc001xhg.3, uc001xhg.4, ZBT25_HUMAN, ZNF46 UCSC ID: uc001xhg.4 RefSeq Accession: NM_001304507
(aka ZBT25_HUMAN) P24278
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.