Human Gene ZBTB25 (ENST00000394715.1) Description and Page Index
  Description: Homo sapiens zinc finger and BTB domain containing 25 (ZBTB25), transcript variant 8, mRNA. (from RefSeq NM_001354686)
Gencode Transcript: ENST00000394715.1
Gencode Gene: ENSG00000089775.11
Transcript (Including UTRs)
   Position: hg38 chr14:64,486,839-64,504,584 Size: 17,746 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg38 chr14:64,486,923-64,490,533 Size: 3,611 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:64,486,839-64,504,584)mRNA (may differ from genome)Protein (435 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger and BTB domain-containing protein 25; AltName: Full=Zinc finger protein 46; AltName: Full=Zinc finger protein KUP;
FUNCTION: May be involved in transcriptional regulation.
INTERACTION: Q99750:MDFI; NbExp=2; IntAct=EBI-739899, EBI-724076;
TISSUE SPECIFICITY: Expressed mainly in hematopoietic cells and testis.
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 2 C2H2-type zinc fingers.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.17 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 113.55 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -227.30702-0.324 Picture PostScript Text
3' UTR -13.2084-0.157 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00651 - BTB/POZ domain
PF00096 - Zinc finger, C2H2 type

ModBase Predicted Comparative 3D Structure on P24278
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0010467 gene expression

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  BC014650 - Homo sapiens mRNA similar to zinc finger protein 46 (KUP) (cDNA clone IMAGE:4564508).
BC035804 - Homo sapiens zinc finger and BTB domain containing 25, mRNA (cDNA clone MGC:46128 IMAGE:5745935), complete cds.
AK098181 - Homo sapiens cDNA FLJ40862 fis, clone TRACH2018262, highly similar to Zinc finger and BTB domain-containing protein 25.
AK313889 - Homo sapiens cDNA, FLJ94524.
X16576 - Human KUP mRNA for protein with two zinc fingers.
JF432133 - Synthetic construct Homo sapiens clone IMAGE:100073273 zinc finger and BTB domain containing 25 (ZBTB25) gene, encodes complete protein.
KJ892409 - Synthetic construct Homo sapiens clone ccsbBroadEn_01803 ZBTB25 gene, encodes complete protein.
EU446912 - Synthetic construct Homo sapiens clone IMAGE:100070220; IMAGE:100012121; FLH257364.01L zinc finger and BTB domain containing 25 (ZBTB25) gene, encodes complete protein.
AB587459 - Synthetic construct DNA, clone: pF1KB8178, Homo sapiens ZBTB25 gene for zinc finger and BTB domain containing 25, without stop codon, in Flexi system.
CU690202 - Synthetic construct Homo sapiens gateway clone IMAGE:100019384 5' read ZBTB25 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KUX6, C14orf51, KUP, NM_001354686, P24278, Q8IYH9, uc001xhg.1, uc001xhg.2, uc001xhg.3, uc001xhg.4, ZBT25_HUMAN, ZNF46
UCSC ID: uc001xhg.4
RefSeq Accession: NM_001304507
Protein: P24278 (aka ZBT25_HUMAN)
CCDS: CCDS9765.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.