Human Gene ZBTB25 (ENST00000394715.1) Description and Page Index
  Description: Homo sapiens zinc finger and BTB domain containing 25 (ZBTB25), transcript variant 8, mRNA. (from RefSeq NM_001354686)
Gencode Transcript: ENST00000394715.1
Gencode Gene: ENSG00000089775.11
Transcript (Including UTRs)
   Position: hg38 chr14:64,486,839-64,504,584 Size: 17,746 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg38 chr14:64,486,923-64,490,533 Size: 3,611 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:64,486,839-64,504,584)mRNA (may differ from genome)Protein (435 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ZBT25_HUMAN
DESCRIPTION: RecName: Full=Zinc finger and BTB domain-containing protein 25; AltName: Full=Zinc finger protein 46; AltName: Full=Zinc finger protein KUP;
FUNCTION: May be involved in transcriptional regulation.
INTERACTION: Q99750:MDFI; NbExp=2; IntAct=EBI-739899, EBI-724076;
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed mainly in hematopoietic cells and testis.
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 2 C2H2-type zinc fingers.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.17 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 113.55 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -227.30702-0.324 Picture PostScript Text
3' UTR -13.2084-0.157 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00651 - BTB/POZ domain
PF00096 - Zinc finger, C2H2 type

ModBase Predicted Comparative 3D Structure on P24278
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0010467 gene expression

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC014650 - Homo sapiens mRNA similar to zinc finger protein 46 (KUP) (cDNA clone IMAGE:4564508).
BC035804 - Homo sapiens zinc finger and BTB domain containing 25, mRNA (cDNA clone MGC:46128 IMAGE:5745935), complete cds.
AK098181 - Homo sapiens cDNA FLJ40862 fis, clone TRACH2018262, highly similar to Zinc finger and BTB domain-containing protein 25.
AK313889 - Homo sapiens cDNA, FLJ94524.
X16576 - Human KUP mRNA for protein with two zinc fingers.
JF432133 - Synthetic construct Homo sapiens clone IMAGE:100073273 zinc finger and BTB domain containing 25 (ZBTB25) gene, encodes complete protein.
KJ892409 - Synthetic construct Homo sapiens clone ccsbBroadEn_01803 ZBTB25 gene, encodes complete protein.
EU446912 - Synthetic construct Homo sapiens clone IMAGE:100070220; IMAGE:100012121; FLH257364.01L zinc finger and BTB domain containing 25 (ZBTB25) gene, encodes complete protein.
AB587459 - Synthetic construct DNA, clone: pF1KB8178, Homo sapiens ZBTB25 gene for zinc finger and BTB domain containing 25, without stop codon, in Flexi system.
CU690202 - Synthetic construct Homo sapiens gateway clone IMAGE:100019384 5' read ZBTB25 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KUX6, C14orf51, KUP, NM_001354686, P24278, Q8IYH9, uc001xhg.1, uc001xhg.2, uc001xhg.3, uc001xhg.4, ZBT25_HUMAN, ZNF46
UCSC ID: uc001xhg.4
RefSeq Accession: NM_001304507
Protein: P24278 (aka ZBT25_HUMAN)
CCDS: CCDS9765.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.