Human Gene TRPT1 (ENST00000394547.7) Description and Page Index
  Description: Homo sapiens tRNA phosphotransferase 1 (TRPT1), transcript variant 2, mRNA. (from RefSeq NM_031472)
Gencode Transcript: ENST00000394547.7
Gencode Gene: ENSG00000149743.14
Transcript (Including UTRs)
   Position: hg38 chr11:64,223,799-64,226,150 Size: 2,352 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr11:64,223,876-64,225,508 Size: 1,633 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:64,223,799-64,226,150)mRNA (may differ from genome)Protein (204 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtOMIMPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=tRNA 2'-phosphotransferase 1; EC=;
FUNCTION: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate (Probable).
CATALYTIC ACTIVITY: 2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H(2)O.
TISSUE SPECIFICITY: Widely expressed. Weakly or not expressed in lung, spleen, small intestine and peripheral blood leukocytes.
SIMILARITY: Belongs to the KptA/TPT1 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 59.64 RPKM in Muscle - Skeletal
Total median expression: 1362.22 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -77.90173-0.450 Picture PostScript Text
3' UTR -3.4077-0.044 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002745 - Ptrans_KptA/Tpt1

Pfam Domains:
PF01885 - RNA 2'-phosphotransferase, Tpt1 / KptA family

ModBase Predicted Comparative 3D Structure on Q86TN4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000215 tRNA 2'-phosphotransferase activity
GO:0003674 molecular_function
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups

Biological Process:
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0008033 tRNA processing
GO:0008150 biological_process
GO:0045859 regulation of protein kinase activity

-  Descriptions from all associated GenBank mRNAs
  BC005133 - Homo sapiens tRNA phosphotransferase 1, mRNA (cDNA clone MGC:11134 IMAGE:3836683), complete cds.
AK026364 - Homo sapiens cDNA: FLJ22711 fis, clone HSI13348.
AY211494 - Homo sapiens tRNA splicing 2' phosphotransferase 1 mRNA, complete cds.
JD485215 - Sequence 466239 from Patent EP1572962.
HQ448355 - Synthetic construct Homo sapiens clone IMAGE:100071779; CCSB004358_02 tRNA phosphotransferase 1 (TRPT1) gene, encodes complete protein.
KJ899716 - Synthetic construct Homo sapiens clone ccsbBroadEn_09110 TRPT1 gene, encodes complete protein.
JD143335 - Sequence 124359 from Patent EP1572962.
JD138997 - Sequence 120021 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8MYC9, NM_031472, Q86TN4, Q9BSB9, TRPT1_HUMAN, uc001nyn.1, uc001nyn.2, uc001nyn.3, uc001nyn.4
UCSC ID: uc001nyn.4
RefSeq Accession: NM_001160389
Protein: Q86TN4 (aka TRPT1_HUMAN)
CCDS: CCDS44639.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.