Human Gene BAD (ENST00000394531.3) Description and Page Index
Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt A8MXU7) RefSeq Summary (NM_032989): The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000394531.3 Gencode Gene: ENSG00000002330.13 Transcript (Including UTRs) Position: hg38 chr11:64,270,256-64,284,653 Size: 14,398 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr11:64,271,639-64,284,368 Size: 12,730 Coding Exon Count: 3
ID:A8MXU7_HUMAN DESCRIPTION: SubName: Full=Bcl2 antagonist of cell death; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF10514 - Pro-apoptotic Bcl-2 protein, BAD
ModBase Predicted Comparative 3D Structure on A8MXU7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.