Human Gene PRPF31 (ENST00000391755.1) Description and Page Index
Description: Contains 1 Nop domain. (from UniProt E7EVX8) RefSeq Summary (NM_015629): This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB593025.1, SRR3476690.463790.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000321030.9/ ENSP00000324122.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Gencode Transcript: ENST00000391755.1 Gencode Gene: ENSG00000105618.14 Transcript (Including UTRs) Position: hg38 chr19:54,118,271-54,131,709 Size: 13,439 Total Exon Count: 13 Strand: + Coding Region Position: hg38 chr19:54,118,279-54,131,432 Size: 13,154 Coding Exon Count: 13
ID:E7EVX8_HUMAN DESCRIPTION: SubName: Full=U4/U6 small nuclear ribonucleoprotein Prp31; SIMILARITY: Contains 1 Nop domain. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on E7EVX8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.