Human Gene NUTM2A (ENST00000381689.4) Description and Page Index
  Description: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IVF1-1; Sequence=Displayed; Name=2; IsoId=Q8IVF1-2; Sequence=VSP_034018, VSP_034020; (from UniProt Q8IVF1)
Gencode Transcript: ENST00000381689.4
Gencode Gene: ENSG00000184923.12
Transcript (Including UTRs)
   Position: hg38 chr10:87,225,500-87,236,908 Size: 11,409 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr10:87,225,831-87,235,155 Size: 9,325 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsRNA-Seq ExpressionRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:87,225,500-87,236,908)mRNA (may differ from genome)Protein (629 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
MGIneXtProtPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein FAM22A;
SIMILARITY: Belongs to the FAM22 family.
SEQUENCE CAUTION: Sequence=BAC23116.1; Type=Frameshift; Positions=83; Sequence=CAH72466.1; Type=Erroneous gene model prediction;

-  MalaCards Disease Associations
  MalaCards Gene Search: NUTM2A
Diseases sorted by gene-association score: endometrial stromal sarcoma* (179), endometrial stromal nodule (2)
* = Manually curated disease association

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.38 RPKM in Testis
Total median expression: 9.30 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -95.10331-0.287 Picture PostScript Text
3' UTR -758.801753-0.433 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024310 - NUT/FAM22
IPR024313 - NUT_C
IPR024309 - NUT_N

Pfam Domains:
PF12882 - n/a
PF12881 - NUT protein

ModBase Predicted Comparative 3D Structure on Q8IVF1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein Sequence     

-  Descriptions from all associated GenBank mRNAs
  AB095940 - Homo sapiens mRNA for KIAA2020 protein.
BC092519 - Homo sapiens cDNA clone IMAGE:3092297.
JD255490 - Sequence 236514 from Patent EP1572962.
JD477387 - Sequence 458411 from Patent EP1572962.
JD163890 - Sequence 144914 from Patent EP1572962.
JD199232 - Sequence 180256 from Patent EP1572962.
JD253753 - Sequence 234777 from Patent EP1572962.
JD499829 - Sequence 480853 from Patent EP1572962.
DQ593562 - Homo sapiens piRNA piR-33674, complete sequence.
BC033231 - Homo sapiens family with sequence similarity 22, member A, mRNA (cDNA clone IMAGE:5258548), partial cds.
JD276285 - Sequence 257309 from Patent EP1572962.
JD317835 - Sequence 298859 from Patent EP1572962.
DQ593595 - Homo sapiens piRNA piR-33707, complete sequence.
DQ585066 - Homo sapiens piRNA piR-52178, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NMX5, AB095940, C9JDI1, FA22A_HUMAN, FAM22A, KIAA2020, Q5VZW1, Q8IVF1, uc057uro.1
UCSC ID: uc057uro.1
RefSeq Accession: NM_001099338
Protein: Q8IVF1 (aka FA22A_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.