Human Gene DIP2C (ENST00000381496.7) Description and Page Index
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt E7EPU2)
RefSeq Summary (NM_014974): This gene encodes a member of the disco-interacting protein homolog 2 family. The protein shares strong similarity with a Drosophila protein which interacts with the transcription factor disco and is expressed in the nervous system. [provided by RefSeq, Oct 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063313.1, AB023151.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000280886.12/ ENSP00000280886.6 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000381496.7
Gencode Gene: ENSG00000151240.17
Transcript (Including UTRs)
   Position: hg38 chr10:274,190-486,558 Size: 212,369 Total Exon Count: 36 Strand: -
Coding Region
   Position: hg38 chr10:277,325-486,558 Size: 209,234 Coding Exon Count: 36 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:274,190-486,558)mRNA (may differ from genome)Protein (1537 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGImyGene2PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: E7EPU2_HUMAN
DESCRIPTION: SubName: Full=Disco-interacting protein 2 homolog C;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.74 RPKM in Colon - Sigmoid
Total median expression: 287.01 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -888.603135-0.283 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000873 - AMP-dep_Synth/Lig

Pfam Domains:
PF00501 - AMP-binding enzyme

ModBase Predicted Comparative 3D Structure on E7EPU2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD Ensembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003824 catalytic activity

Biological Process:
GO:0008152 metabolic process


-  Descriptions from all associated GenBank mRNAs
  AB023151 - Homo sapiens KIAA0934 mRNA for KIAA0934 protein.
BC063313 - Homo sapiens DIP2 disco-interacting protein 2 homolog C (Drosophila), mRNA (cDNA clone MGC:71829 IMAGE:30349267), complete cds.
AB384049 - Synthetic construct DNA, clone: pF1KSDA0934, Homo sapiens DIP2C gene for disco-interacting protein 2 homolog C, complete cds, without stop codon, in Flexi system.
AK126063 - Homo sapiens cDNA FLJ44075 fis, clone TESTI4038339, highly similar to Disco-interacting protein 2 homolog C.
AK310613 - Homo sapiens cDNA, FLJ17655.
AX803815 - Sequence 11 from Patent WO03060129.
BC035216 - Homo sapiens DIP2 disco-interacting protein 2 homolog C (Drosophila), mRNA (cDNA clone IMAGE:4748955).
BX537672 - Homo sapiens mRNA; cDNA DKFZp686J01130 (from clone DKFZp686J01130).
JD346342 - Sequence 327366 from Patent EP1572962.
JD550697 - Sequence 531721 from Patent EP1572962.
JD347514 - Sequence 328538 from Patent EP1572962.
JD158592 - Sequence 139616 from Patent EP1572962.
JD124083 - Sequence 105107 from Patent EP1572962.
JD461487 - Sequence 442511 from Patent EP1572962.
JD338093 - Sequence 319117 from Patent EP1572962.
JD198553 - Sequence 179577 from Patent EP1572962.
JD289121 - Sequence 270145 from Patent EP1572962.
DQ600361 - Homo sapiens piRNA piR-38427, complete sequence.
JD298742 - Sequence 279766 from Patent EP1572962.
JD469746 - Sequence 450770 from Patent EP1572962.
JD298798 - Sequence 279822 from Patent EP1572962.
AK311679 - Homo sapiens cDNA, FLJ18721.
JD171069 - Sequence 152093 from Patent EP1572962.
BC048327 - Homo sapiens DIP2 disco-interacting protein 2 homolog C (Drosophila), mRNA (cDNA clone IMAGE:5163354), partial cds.
AK093390 - Homo sapiens cDNA FLJ36071 fis, clone TESTI2019501.
AK309715 - Homo sapiens cDNA, FLJ99756.
JD073733 - Sequence 54757 from Patent EP1572962.
JD456361 - Sequence 437385 from Patent EP1572962.
AX803822 - Sequence 18 from Patent WO03060129.
JD229494 - Sequence 210518 from Patent EP1572962.
JD554377 - Sequence 535401 from Patent EP1572962.
AX803814 - Sequence 10 from Patent WO03060129.
AX803813 - Sequence 9 from Patent WO03060129.
AX803816 - Sequence 12 from Patent WO03060129.
AX803812 - Sequence 8 from Patent WO03060129.
AK310018 - Homo sapiens cDNA, FLJ17060.
AX803818 - Sequence 14 from Patent WO03060129.
MP015017 - Sequence 220 from Patent WO2019016252.
AK298353 - Homo sapiens cDNA FLJ50825 complete cds, highly similar to Disco-interacting protein 2 homolog C.
AX803824 - Sequence 20 from Patent WO03060129.
AX803819 - Sequence 15 from Patent WO03060129.
AX803825 - Sequence 21 from Patent WO03060129.

-  Other Names for This Gene
  Alternate Gene Symbols: AB023151, E7EPU2, E7EPU2_HUMAN, uc057rds.1
UCSC ID: uc057rds.1
RefSeq Accession: NM_014974
Protein: E7EPU2 CCDS: CCDS7054.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.