Human Gene CD81 (ENST00000381036.7) Description and Page Index
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt A6NMH8)
RefSeq Summary (NM_001297649): The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
Gencode Transcript: ENST00000381036.7
Gencode Gene: ENSG00000110651.11
Transcript (Including UTRs)
   Position: hg38 chr11:2,386,057-2,396,916 Size: 10,860 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg38 chr11:2,386,062-2,396,866 Size: 10,805 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:2,386,057-2,396,916)mRNA (may differ from genome)Protein (274 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: A6NMH8_HUMAN
DESCRIPTION: SubName: Full=CD81 antigen;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: CD81
Diseases sorted by gene-association score: immunodeficiency, common variable, 6* (919), cd81-related common variable immune deficiency* (400), common variable immunodeficiency* (118), hepatitis c (45), hepatitis (13), cryoglobulinemia (10), hepatitis c virus (8), pediatric lymphoma (7), atrial septal defect 1 (7), malaria (4), viral infectious disease (2), hepatocellular carcinoma (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 384.40 RPKM in Uterus
Total median expression: 8481.78 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -15.1050-0.302 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023396 - CD81_extracellular
IPR000301 - Tetraspanin
IPR018499 - Tetraspanin/Peripherin
IPR018503 - Tetraspanin_CS
IPR008952 - Tetraspanin_EC2

Pfam Domains:
PF00335 - Tetraspanin family

ModBase Predicted Comparative 3D Structure on A6NMH8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF205116 - JP 2014500723-A/12619: Polycomb-Associated Non-Coding RNAs.
MA440693 - JP 2018138019-A/12619: Polycomb-Associated Non-Coding RNAs.
LF207989 - JP 2014500723-A/15492: Polycomb-Associated Non-Coding RNAs.
MA443566 - JP 2018138019-A/15492: Polycomb-Associated Non-Coding RNAs.
LF213931 - JP 2014500723-A/21434: Polycomb-Associated Non-Coding RNAs.
MA449508 - JP 2018138019-A/21434: Polycomb-Associated Non-Coding RNAs.
BC093047 - Homo sapiens CD81 molecule, mRNA (cDNA clone MGC:111086 IMAGE:30398483), complete cds.
M33680 - Human 26-kDa cell surface protein TAPA-1 mRNA, complete cds.
BC002978 - Homo sapiens CD81 molecule, mRNA (cDNA clone MGC:2221 IMAGE:3510634), complete cds.
DQ891836 - Synthetic construct clone IMAGE:100004466; FLH180429.01X; RZPDo839C02134D CD81 molecule (CD81) gene, encodes complete protein.
DQ891849 - Synthetic construct Homo sapiens clone IMAGE:100004479; FLH263553.01X; RZPDo839D11134D CD81 molecule (CD81) gene, encodes complete protein.
DQ895022 - Synthetic construct Homo sapiens clone IMAGE:100009482; FLH180425.01L; RZPDo839C02133D CD81 molecule (CD81) gene, encodes complete protein.
KJ890874 - Synthetic construct Homo sapiens clone ccsbBroadEn_00268 CD81 gene, encodes complete protein.
BT019507 - Homo sapiens CD81 antigen (target of antiproliferative antibody 1) mRNA, complete cds.
BT019508 - Homo sapiens CD81 antigen (target of antiproliferative antibody 1) mRNA, complete cds.
LF205118 - JP 2014500723-A/12621: Polycomb-Associated Non-Coding RNAs.
MA440695 - JP 2018138019-A/12621: Polycomb-Associated Non-Coding RNAs.
LF205120 - JP 2014500723-A/12623: Polycomb-Associated Non-Coding RNAs.
MA440697 - JP 2018138019-A/12623: Polycomb-Associated Non-Coding RNAs.
LF370754 - JP 2014500723-A/178257: Polycomb-Associated Non-Coding RNAs.
MA606331 - JP 2018138019-A/178257: Polycomb-Associated Non-Coding RNAs.
AB209380 - Homo sapiens mRNA for CD81 antigen variant protein.
LF370759 - JP 2014500723-A/178262: Polycomb-Associated Non-Coding RNAs.
MA606336 - JP 2018138019-A/178262: Polycomb-Associated Non-Coding RNAs.
LF370760 - JP 2014500723-A/178263: Polycomb-Associated Non-Coding RNAs.
MA606337 - JP 2018138019-A/178263: Polycomb-Associated Non-Coding RNAs.
LF370763 - JP 2014500723-A/178266: Polycomb-Associated Non-Coding RNAs.
MA606340 - JP 2018138019-A/178266: Polycomb-Associated Non-Coding RNAs.
KM576715 - Homo sapiens clone CD81-TSSC4_C8middle-T1 mRNA sequence.
LF370765 - JP 2014500723-A/178268: Polycomb-Associated Non-Coding RNAs.
MA606342 - JP 2018138019-A/178268: Polycomb-Associated Non-Coding RNAs.
LF370766 - JP 2014500723-A/178269: Polycomb-Associated Non-Coding RNAs.
MA606343 - JP 2018138019-A/178269: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04662 - B cell receptor signaling pathway

-  Other Names for This Gene
  Alternate Gene Symbols: A6NMH8, A6NMH8_HUMAN, BC002978, uc057xxr.1
UCSC ID: uc057xxr.1
RefSeq Accession: NM_001297649
Protein: A6NMH8

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.