Human Gene HNRNPUL1 (ENST00000378215.8) Description and Page Index
  Description: Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand- stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. (from UniProt Q9BUJ2)
RefSeq Summary (NM_007040): This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016].
Gencode Transcript: ENST00000378215.8
Gencode Gene: ENSG00000105323.17
Transcript (Including UTRs)
   Position: hg38 chr19:41,264,372-41,307,038 Size: 42,667 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg38 chr19:41,264,504-41,306,565 Size: 42,062 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:41,264,372-41,307,038)mRNA (may differ from genome)Protein (752 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCHPRD
LynxMGIneXtProtPubMedReactomeStanford SOURCE
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: HNRL1_HUMAN
DESCRIPTION: RecName: Full=Heterogeneous nuclear ribonucleoprotein U-like protein 1; AltName: Full=Adenovirus early region 1B-associated protein 5; AltName: Full=E1B-55 kDa-associated protein 5; Short=E1B-AP5;
FUNCTION: Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand- stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.
SUBUNIT: Interacts with the adenovirus type 5 (Ad5) E1B-55 kDa, BRD7, PRMT2, TP53 and NXF1. Associates with histones and BRD7.
INTERACTION: P04637:TP53; NbExp=11; IntAct=EBI-1018153, EBI-366083;
SUBCELLULAR LOCATION: Nucleus.
DOMAIN: The RGG-box domain is methylated.
PTM: Methylated.
MISCELLANEOUS: Its methylation is enhanced in the late phase of adenoviral infection.
SIMILARITY: Contains 1 B30.2/SPRY domain.
SIMILARITY: Contains 1 SAP domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 55.28 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1512.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -69.00132-0.523 Picture PostScript Text
3' UTR -138.41473-0.293 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001870 - B30.2/SPRY
IPR008985 - ConA-like_lec_gl_sf
IPR003034 - SAP_DNA-bd
IPR018355 - SPla/RYanodine_receptor_subgr
IPR003877 - SPRY_rcpt

Pfam Domains:
PF02037 - SAP domain
PF00622 - SPRY domain

ModBase Predicted Comparative 3D Structure on Q9BUJ2
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0019899 enzyme binding

Biological Process:
GO:0000398 mRNA splicing, via spliceosome
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006396 RNA processing
GO:0009615 response to virus

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm


-  Descriptions from all associated GenBank mRNAs
  AK225850 - Homo sapiens mRNA for E1B-55kDa-associated protein 5 isoform a variant, clone: FCC125H07.
AK023006 - Homo sapiens cDNA FLJ12944 fis, clone NT2RP2005168, highly similar to Homo sapiens mRNA for E1B-55kDa-associated protein.
AK308078 - Homo sapiens cDNA, FLJ98026.
AJ007509 - Homo sapiens mRNA for E1B-55kDa-associated protein.
AK291762 - Homo sapiens cDNA FLJ78252 complete cds, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein U-like 1 (HNRPUL1), transcript variant 1, mRNA.
AK127057 - Homo sapiens cDNA FLJ45114 fis, clone BRAWH3034775, highly similar to Homo sapiens E1B-55kDa-associated protein 5 (E1B-AP5).
AK022863 - Homo sapiens cDNA FLJ12801 fis, clone NT2RP2002099, highly similar to Heterogeneous nuclear ribonucleoprotein U-like protein 1.
AK308156 - Homo sapiens cDNA, FLJ98104.
BC009988 - Homo sapiens heterogeneous nuclear ribonucleoprotein U-like 1, mRNA (cDNA clone MGC:16706 IMAGE:4127873), complete cds.
AK291315 - Homo sapiens cDNA FLJ78309 complete cds, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein U-like 1 (HNRPUL1), transcript variant 1, mRNA.
BC002564 - Homo sapiens heterogeneous nuclear ribonucleoprotein U-like 1, mRNA (cDNA clone MGC:1974 IMAGE:3139049), complete cds.
BC014232 - Homo sapiens heterogeneous nuclear ribonucleoprotein U-like 1, mRNA (cDNA clone MGC:20910 IMAGE:4558792), complete cds.
BC027713 - Homo sapiens heterogeneous nuclear ribonucleoprotein U-like 1, mRNA (cDNA clone MGC:16645 IMAGE:4123077), complete cds.
BC004242 - Homo sapiens heterogeneous nuclear ribonucleoprotein U-like 1, mRNA (cDNA clone IMAGE:3619753), complete cds.
AB384748 - Synthetic construct DNA, clone: pF1KB3100, Homo sapiens HNRPUL1 gene for heterogeneous nuclear ribonucleoprotein U-like protein 1, complete cds, without stop codon, in Flexi system.
EU831487 - Synthetic construct Homo sapiens clone HAIB:100066516; DKFZo008H0517 heterogeneous nuclear ribonucleoprotein U-like 1 protein (HNRPUL1) gene, encodes complete protein.
EU831574 - Synthetic construct Homo sapiens clone HAIB:100066603; DKFZo004H0518 heterogeneous nuclear ribonucleoprotein U-like 1 protein (HNRPUL1) gene, encodes complete protein.
KJ898356 - Synthetic construct Homo sapiens clone ccsbBroadEn_07750 HNRNPUL1 gene, encodes complete protein.
KJ902200 - Synthetic construct Homo sapiens clone ccsbBroadEn_11594 HNRNPUL1 gene, encodes complete protein.
KJ906068 - Synthetic construct Homo sapiens clone ccsbBroadEn_15738 HNRNPUL1 gene, encodes complete protein.
AK290729 - Homo sapiens cDNA FLJ75163 complete cds, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein U-like 1 (HNRPUL1), transcript variant 4, mRNA.
AK297127 - Homo sapiens cDNA FLJ56481 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein U-like protein 1.
KJ898355 - Synthetic construct Homo sapiens clone ccsbBroadEn_07749 HNRNPUL1 gene, encodes complete protein.
EU831452 - Synthetic construct Homo sapiens clone HAIB:100066481; DKFZo008E0417 heterogeneous nuclear ribonucleoprotein U-like 1 protein (HNRPUL1) gene, encodes complete protein.
EU831539 - Synthetic construct Homo sapiens clone HAIB:100066568; DKFZo004E0418 heterogeneous nuclear ribonucleoprotein U-like 1 protein (HNRPUL1) gene, encodes complete protein.
JD254565 - Sequence 235589 from Patent EP1572962.
JD485294 - Sequence 466318 from Patent EP1572962.
JD075920 - Sequence 56944 from Patent EP1572962.
CU693286 - Synthetic construct Homo sapiens gateway clone IMAGE:100023203 5' read HNRPUL1 mRNA.
CU678042 - Synthetic construct Homo sapiens gateway clone IMAGE:100020484 5' read HNRPUL1 mRNA.
CU679555 - Synthetic construct Homo sapiens gateway clone IMAGE:100020433 5' read HNRPUL1 mRNA.
AL050146 - Homo sapiens mRNA; cDNA DKFZp586D0920 (from clone DKFZp586D0920).
AK001229 - Homo sapiens cDNA FLJ10367 fis, clone NT2RM2001424, highly similar to Heterogeneous nuclear ribonucleoprotein U-like protein 1.
AK021455 - Homo sapiens cDNA FLJ11393 fis, clone HEMBA1000591, weakly similar to PTB-ASSOCIATED SPLICING FACTOR.
JD407938 - Sequence 388962 from Patent EP1572962.
JD336550 - Sequence 317574 from Patent EP1572962.
JD089081 - Sequence 70105 from Patent EP1572962.
JD108824 - Sequence 89848 from Patent EP1572962.
JD359453 - Sequence 340477 from Patent EP1572962.
JD547131 - Sequence 528155 from Patent EP1572962.
JD415822 - Sequence 396846 from Patent EP1572962.
JD556611 - Sequence 537635 from Patent EP1572962.
BC000860 - Homo sapiens heterogeneous nuclear ribonucleoprotein U-like 1, mRNA (cDNA clone IMAGE:3459524).
U55217 - Human RNA fragment from patients with Crohn's disease and ulcerative colitis.
JD520090 - Sequence 501114 from Patent EP1572962.
JD095178 - Sequence 76202 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BUJ2 (Reactome details) participates in the following event(s):

R-HSA-72107 Formation of the Spliceosomal E complex
R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage
R-HSA-72139 Formation of the active Spliceosomal C (B*) complex
R-HSA-72124 Formation of the Spliceosomal A Complex
R-HSA-72127 Formation of the Spliceosomal B Complex
R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex
R-HSA-156661 Formation of Exon Junction Complex
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72172 mRNA Splicing
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-8953854 Metabolism of RNA

-  Other Names for This Gene
  Alternate Gene Symbols: AK127057, B3KMW7, E1BAP5, HNRL1_HUMAN, HNRPUL1, O76022, Q6ZSZ0, Q7L8P4, Q8N6Z4, Q96G37, Q9BUJ2, Q9HAL3, Q9UG75, uc002oqc.1, uc002oqc.2, uc002oqc.3, uc002oqc.4, uc002oqc.5
UCSC ID: uc002oqc.5
RefSeq Accession: NM_007040
Protein: Q9BUJ2 (aka HNRL1_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.