Human Gene THAP3 (ENST00000377627.7) Description and Page Index
  Description: Homo sapiens THAP domain containing 3 (THAP3), transcript variant 2, mRNA. (from RefSeq NM_138350)
Gencode Transcript: ENST00000377627.7
Gencode Gene: ENSG00000041988.15
Transcript (Including UTRs)
   Position: hg38 chr1:6,625,192-6,635,586 Size: 10,395 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr1:6,625,219-6,634,088 Size: 8,870 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:6,625,192-6,635,586)mRNA (may differ from genome)Protein (175 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: THAP3_HUMAN
DESCRIPTION: RecName: Full=THAP domain-containing protein 3;
FUNCTION: Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.
SUBUNIT: Component of a THAP1/THAP3-HCFC1-OGT complex that contains at least, either THAP1 or THAP3, HCFC1 and OGT. Interacts directly with OGT and HCFC1 (via its HBM).
TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle and placenta. Weaker expression in brain, kidney and liver.
SIMILARITY: Contains 1 THAP-type zinc finger.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.76 RPKM in Uterus
Total median expression: 312.19 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.3027-0.270 Picture PostScript Text
3' UTR -647.801498-0.432 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026520 - THAP3
IPR006612 - Znf_C2CH

Pfam Domains:
PF05485 - THAP domain

ModBase Predicted Comparative 3D Structure on Q8WTV1
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006357 regulation of transcription from RNA polymerase II promoter


-  Descriptions from all associated GenBank mRNAs
  BC092427 - Homo sapiens THAP domain containing, apoptosis associated protein 3, mRNA (cDNA clone MGC:102992 IMAGE:30376814), complete cds.
AK096217 - Homo sapiens cDNA FLJ38898 fis, clone NT2NE2000374.
BC022081 - Homo sapiens THAP domain containing, apoptosis associated protein 3, mRNA (cDNA clone IMAGE:4813302), with apparent retained intron.
DQ891670 - Synthetic construct clone IMAGE:100004300; FLH179145.01X; RZPDo839D04130D THAP domain containing, apoptosis associated protein 3 (THAP3) gene, encodes complete protein.
DQ894856 - Synthetic construct Homo sapiens clone IMAGE:100009316; FLH179141.01L; RZPDo839D04129D THAP domain containing, apoptosis associated protein 3 (THAP3) gene, encodes complete protein.
BC005114 - Homo sapiens THAP domain containing, apoptosis associated protein 3, mRNA (cDNA clone IMAGE:4053044), partial cds.
JD021074 - Sequence 2098 from Patent EP1572962.
JD034296 - Sequence 15320 from Patent EP1572962.
AF086370 - Homo sapiens full length insert cDNA clone ZD67D08.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_138350, Q569K1, Q5TH66, Q5TH67, Q8N8T6, Q8WTV1, Q9BSC7, Q9Y3H2, Q9Y3H3, THAP3_HUMAN, uc001aoe.1, uc001aoe.2, uc001aoe.3
UCSC ID: uc001aoe.3
RefSeq Accession: NM_138350
Protein: Q8WTV1 (aka THAP3_HUMAN or THA3_HUMAN)
CCDS: CCDS86.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.