Human Gene DNAJC11 (ENST00000377577.10) Description and Page Index
  Description: Homo sapiens DnaJ heat shock protein family (Hsp40) member C11 (DNAJC11), mRNA. (from RefSeq NM_018198)
Gencode Transcript: ENST00000377577.10
Gencode Gene: ENSG00000007923.16
Transcript (Including UTRs)
   Position: hg38 chr1:6,634,170-6,701,816 Size: 67,647 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg38 chr1:6,635,675-6,701,800 Size: 66,126 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:6,634,170-6,701,816)mRNA (may differ from genome)Protein (559 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: DJC11_HUMAN
DESCRIPTION: RecName: Full=DnaJ homolog subfamily C member 11;
SIMILARITY: Belongs to the DNAJC11 family.
SIMILARITY: Contains 1 J domain.
SEQUENCE CAUTION: Sequence=AAH08772.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.97 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 406.45 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR 0.00160.000 Picture PostScript Text
3' UTR -586.101505-0.389 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024586 - DnaJ-like_C11_C
IPR001623 - DnaJ_N
IPR018253 - Heat_shock_DnaJ_CS
IPR003095 - Hsp_DnaJ

Pfam Domains:
PF00226 - DnaJ domain
PF11875 - Domain of unknown function (DUF3395)

ModBase Predicted Comparative 3D Structure on Q9NVH1
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsemblWormBase 
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0042407 cristae formation

Cellular Component:
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane
GO:0001401 mitochondrial sorting and assembly machinery complex
GO:0061617 MICOS complex


-  Descriptions from all associated GenBank mRNAs
  AF306695 - Homo sapiens clone R5' mRNA sequence.
AL833841 - Homo sapiens mRNA; cDNA DKFZp727C181 (from clone DKFZp727C181).
BC008772 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 11, mRNA (cDNA clone IMAGE:3139659), partial cds.
BC006086 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 11, mRNA (cDNA clone MGC:12593 IMAGE:3946414), complete cds.
AK001599 - Homo sapiens cDNA FLJ10737 fis, clone NT2RP3001426, weakly similar to DNAJ PROTEIN.
BC014145 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 11, mRNA (cDNA clone MGC:20641 IMAGE:4762069), complete cds.
AY336749 - Homo sapiens DNAJ domain-containing protein mRNA, complete cds.
AK294539 - Homo sapiens cDNA FLJ53979 complete cds, highly similar to DnaJ homolog subfamily C member 11.
HQ447595 - Synthetic construct Homo sapiens clone IMAGE:100070938; CCSB014704_02 DnaJ (Hsp40) homolog, subfamily C, member 11 (DNAJC11) gene, encodes complete protein.
KJ899180 - Synthetic construct Homo sapiens clone ccsbBroadEn_08574 DNAJC11 gene, encodes complete protein.
KJ902869 - Synthetic construct Homo sapiens clone ccsbBroadEn_12263 DNAJC11 gene, encodes complete protein.
AF306694 - Homo sapiens clone 305-9E mRNA sequence.
CU675235 - Synthetic construct Homo sapiens gateway clone IMAGE:100023074 5' read DNAJC11 mRNA.
CU680804 - Synthetic construct Homo sapiens gateway clone IMAGE:100019720 5' read DNAJC11 mRNA.
AK025491 - Homo sapiens cDNA: FLJ21838 fis, clone HEP01752, highly similar to AF052158 Homo sapiens clone 24616 mRNA sequence.
AL109978 - Novel human gene mapping to chomosome 1.
AF052158 - Homo sapiens clone 24616 mRNA sequence.
AK093709 - Homo sapiens cDNA FLJ36390 fis, clone THYMU2008990.
AX748271 - Sequence 1796 from Patent EP1308459.
AK095386 - Homo sapiens cDNA FLJ38067 fis, clone CTONG2015345, highly similar to DnaJ homolog subfamily C member 11.
JD235496 - Sequence 216520 from Patent EP1572962.
JD122575 - Sequence 103599 from Patent EP1572962.
JD142279 - Sequence 123303 from Patent EP1572962.
JD295851 - Sequence 276875 from Patent EP1572962.
JD306833 - Sequence 287857 from Patent EP1572962.
JD458952 - Sequence 439976 from Patent EP1572962.
JD199114 - Sequence 180138 from Patent EP1572962.
JD084853 - Sequence 65877 from Patent EP1572962.
JD312308 - Sequence 293332 from Patent EP1572962.
JD240478 - Sequence 221502 from Patent EP1572962.
JD195024 - Sequence 176048 from Patent EP1572962.
JD322131 - Sequence 303155 from Patent EP1572962.
JD132215 - Sequence 113239 from Patent EP1572962.
JD146058 - Sequence 127082 from Patent EP1572962.
JD394687 - Sequence 375711 from Patent EP1572962.
JD371503 - Sequence 352527 from Patent EP1572962.
JD497010 - Sequence 478034 from Patent EP1572962.
JD370697 - Sequence 351721 from Patent EP1572962.
JD096020 - Sequence 77044 from Patent EP1572962.
JD317878 - Sequence 298902 from Patent EP1572962.
JD534383 - Sequence 515407 from Patent EP1572962.
JD155657 - Sequence 136681 from Patent EP1572962.
JD381615 - Sequence 362639 from Patent EP1572962.
JD132236 - Sequence 113260 from Patent EP1572962.
JD232508 - Sequence 213532 from Patent EP1572962.
JD117453 - Sequence 98477 from Patent EP1572962.
JD439026 - Sequence 420050 from Patent EP1572962.
JD419674 - Sequence 400698 from Patent EP1572962.
JD030749 - Sequence 11773 from Patent EP1572962.
JD020437 - Sequence 1461 from Patent EP1572962.
JD126012 - Sequence 107036 from Patent EP1572962.
JD068633 - Sequence 49657 from Patent EP1572962.
JD470836 - Sequence 451860 from Patent EP1572962.
JD373085 - Sequence 354109 from Patent EP1572962.
JD126681 - Sequence 107705 from Patent EP1572962.
JD364191 - Sequence 345215 from Patent EP1572962.
JD223617 - Sequence 204641 from Patent EP1572962.
JD446829 - Sequence 427853 from Patent EP1572962.
JD406045 - Sequence 387069 from Patent EP1572962.
AK298378 - Homo sapiens cDNA FLJ59729 complete cds, highly similar to DnaJ homolog subfamily C member 11.
JD400628 - Sequence 381652 from Patent EP1572962.
JD382362 - Sequence 363386 from Patent EP1572962.
JD160047 - Sequence 141071 from Patent EP1572962.
JD186105 - Sequence 167129 from Patent EP1572962.
JD317139 - Sequence 298163 from Patent EP1572962.
AF306696 - Homo sapiens clone R6r/1-6H mRNA sequence.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NVH1 (Reactome details) participates in the following event(s):

R-HSA-8949613 Cristae formation
R-HSA-1592230 Mitochondrial biogenesis
R-HSA-1852241 Organelle biogenesis and maintenance

-  Other Names for This Gene
  Alternate Gene Symbols: DJC11_HUMAN, NM_018198, Q4VWF5, Q5VZN0, Q6PK20, Q6PK70, Q8NDM2, Q96CL7, Q9NVH1, uc001aof.1, uc001aof.2, uc001aof.3, uc001aof.4
UCSC ID: uc001aof.4
RefSeq Accession: NM_018198
Protein: Q9NVH1 (aka DJC11_HUMAN)
CCDS: CCDS87.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.