Human Gene SYK (ENST00000375747.5) Description and Page Index
  Description: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. Beside its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. (from UniProt P43405)
RefSeq Summary (NM_001174168): This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
Gencode Transcript: ENST00000375747.5
Gencode Gene: ENSG00000165025.15
Transcript (Including UTRs)
   Position: hg38 chr9:90,801,927-90,898,549 Size: 96,623 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg38 chr9:90,843,899-90,895,600 Size: 51,702 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:90,801,927-90,898,549)mRNA (may differ from genome)Protein (612 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIneXtProtPubMedReactomeStanford SOURCEUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: KSYK_HUMAN
DESCRIPTION: RecName: Full=Tyrosine-protein kinase SYK; EC=2.7.10.2; AltName: Full=Spleen tyrosine kinase; AltName: Full=p72-Syk;
FUNCTION: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. Beside its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen.
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
ENZYME REGULATION: Autoinhibited. Intramolecular binding of the interdomains A and B (also called linker region) to parts of the catalytic domain keep the catalytic center in an inactive conformation. The phosphorylation of the interdomains or the binding of the SH2 domains with dually phosphorylated ITAM domains on transmembrane proteins disrupt those intramolecular interactions allowing the kinase domain to adopt an active conformation. The phosphorylation of SYK and of the ITAM domains which is responsible for SYK activation is essentially mediated by SRC subfamily kinases, like LYN, upon transmembrane receptors engagement. May also be negatively regulated by PTPN6 through dephosphorylation. Downstream signaling adapters and intermediates like BLNK or RHOH may mediate positive and/or negative feedback regulation. Negatively regulated by CBL and CBLB through ubiquitination and probable degradation. Phosphorylates SH3BP2 which in turn may regulate SYK through LYN (By similarity).
SUBUNIT: Interacts with LYN; phosphorylates SYK (By similarity). Interacts with RHOH (phosphorylated); regulates mast cells activation (By similarity). Interacts with NFAM1 (phosphorylated); probably involved in BCR signaling (By similarity). Interacts with VAV1 (via SH2 domain); phosphorylates VAV1 upon BCR activation. Interacts with GAB2 (phosphorylated); probably involved in IgE Fc receptor signaling (By similarity). Interacts (via its SH2 domains) with CD79A (via its phosphorylated ITAM domain); the interaction stimulates SYK autophosphorylation and activation (By similarity). Interacts with FCRL3. Interacts (via SH2 domains) with FCER1G (via ITAM domain); activates SYK and mediates neutrophils and macrophages integrin-mediated activation (By similarity). Interacts with ITGB2 and FGR; involved in ITGB2 downstream signaling (By similarity). Interacts with ITGB3; upon activation by ITGB3 promotes platelet adhesion. Interacts (via SH2 domains) with TYROBP (via ITAM domain); involved in neutrophils and macrophages integrin-mediated activation (By similarity). Interacts with MSN and SELPLG; mediates the selectin-dependent activation of SYK by SELPLG. Interacts with BLNK (via SH2 domain). Interacts (via the second SH2 domain) with USP25 (via C-terminus); phosphorylates USP25 and regulates USP25 intracellular levels. Interacts (via SH2 domains) with CLEC1B (dimer). Interacts with CLEC7A; participatex in leukocyte activation in presence of fungal pathogens. Interacts (phosphorylated) with SLA; may regulate SYK through CBL recruitment. Interacts with YWHAG; attenuates BCR- induced membrane translocation and activation of SYK. Interacts with Epstein-Barr virus LMP2A.
INTERACTION: P20273:CD22; NbExp=4; IntAct=EBI-78302, EBI-78277; P11049:CD37; NbExp=3; IntAct=EBI-78302, EBI-6139068;
SUBCELLULAR LOCATION: Cell membrane (Probable). Cytoplasm, cytosol (Probable).
TISSUE SPECIFICITY: Widely expressed in hematopoietic cells (at protein level). Within the B-cells compartment it is for instance expressed for pro-B-cells to plasma cells.
DOMAIN: The SH2 domains mediate the interaction of SYK with the phosphorylated ITAM domains of transmembrane proteins. Some proteins like CLEC1B have a partial ITAM domain (also called hemITAM) containing a single YxxL motif. The interaction with SYK requires CLEC1B homodimerization.
PTM: Ubiquitinated by CBLB after BCR activation; which promotes proteasomal degradation (By similarity).
PTM: Autophosphorylated. Phosphorylated on tyrosine residues by LYN following receptors engagement. Phosphorylation on Tyr-323 creates a binding site for CBL, an adapter protein that serves as a negative regulator of BCR-stimulated calcium ion signaling. Phosphorylation at Tyr-348 creates a binding site for VAV1. Phosphorylation on Tyr-348 and Tyr-352 enhances the phosphorylation and activation of phospholipase C-gamma and the early phase of calcium ion mobilization via a phosphoinositide 3- kinase-independent pathway (By similarity). Phosphorylation on Ser-297 is very common, it peaks 5 minutes after BCR stimulation, and creates a binding site for YWHAG. Phosphorylation at Tyr-630 creates a binding site for BLNK. Dephosphorylated by PTPN6.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
SIMILARITY: Contains 1 protein kinase domain.
SIMILARITY: Contains 2 SH2 domains.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/SYKID394.html";

-  MalaCards Disease Associations
  MalaCards Gene Search: SYK
Diseases sorted by gene-association score: hantavirus pulmonary syndrome (22), mycobacterium abscessus (9), b cell linker protein deficiency (8), nasu-hakola disease (7), rapidly progressive glomerulonephritis (7), spherocytosis, type 1 (5), subcutaneous mycosis (5), intraocular retinoblastoma (5), chronic lymphocytic leukemia (5), cd45 deficiency (5), asthma (3), mantle cell lymphoma (2), lymphoma, non-hodgkin (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C041525 3,3',4,5'-tetrahydroxystilbene
  • D015054 Zymosan
  • C569670 1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one
  • C023514 2,6-dinitrotoluene
  • C028451 3,4,3',4'-tetrachlorobiphenyl
  • D000082 Acetaminophen
  • D000643 Ammonium Chloride
  • D000941 Antigens
  • D003314 Corn Oil
  • D016572 Cyclosporine
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.80 RPKM in Whole Blood
Total median expression: 275.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.80120-0.365 Picture PostScript Text
3' UTR -977.102949-0.331 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR023420 - Kinase_SYK/ZAP-70_inter-SH2
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR001245 - Ser-Thr/Tyr_kinase_cat_dom
IPR000980 - SH2
IPR008266 - Tyr_kinase_AS
IPR020635 - Tyr_kinase_cat_dom
IPR012234 - Tyr_kinase_non-rcpt_SYK/ZAP70

Pfam Domains:
PF07714 - Protein tyrosine kinase
PF00017 - SH2 domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1A81
- X-ray MuPIT

1CSY
- NMR MuPIT

1CSZ
- NMR MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
1XBA - X-ray MuPIT 1XBB - X-ray MuPIT 1XBC - X-ray MuPIT
3BUW - X-ray MuPIT 3EMG - X-ray MuPIT 3FQE - X-ray MuPIT
3FQH - X-ray MuPIT 3FQS - X-ray MuPIT 3SRV - X-ray MuPIT
3TUB - X-ray MuPIT 3TUC - X-ray MuPIT 3TUD - X-ray MuPIT
3VF8 - X-ray MuPIT 3VF9 - X-ray MuPIT 4DFL - X-ray MuPIT
4DFN - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P43405
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0001784 phosphotyrosine binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0035325 Toll-like receptor binding
GO:0042169 SH2 domain binding

Biological Process:
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0001820 serotonin secretion
GO:0001945 lymph vessel development
GO:0002092 positive regulation of receptor internalization
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002250 adaptive immune response
GO:0002281 macrophage activation involved in immune response
GO:0002283 neutrophil activation involved in immune response
GO:0002366 leukocyte activation involved in immune response
GO:0002376 immune system process
GO:0002554 serotonin secretion by platelet
GO:0006468 protein phosphorylation
GO:0006606 protein import into nucleus
GO:0006954 inflammatory response
GO:0007159 leukocyte cell-cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007257 activation of JUN kinase activity
GO:0008283 cell proliferation
GO:0009887 animal organ morphogenesis
GO:0010543 regulation of platelet activation
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016032 viral process
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019370 leukotriene biosynthetic process
GO:0030168 platelet activation
GO:0030593 neutrophil chemotaxis
GO:0031623 receptor internalization
GO:0032481 positive regulation of type I interferon production
GO:0032928 regulation of superoxide anion generation
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035556 intracellular signal transduction
GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038110 interleukin-2-mediated signaling pathway
GO:0042742 defense response to bacterium
GO:0043306 positive regulation of mast cell degranulation
GO:0043313 regulation of neutrophil degranulation
GO:0043366 beta selection
GO:0045087 innate immune response
GO:0045401 positive regulation of interleukin-3 biosynthetic process
GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045579 positive regulation of B cell differentiation
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045780 positive regulation of bone resorption
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0046777 protein autophosphorylation
GO:0048514 blood vessel morphogenesis
GO:0050715 positive regulation of cytokine secretion
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050764 regulation of phagocytosis
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050853 B cell receptor signaling pathway
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0071226 cellular response to molecule of fungal origin
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0090237 regulation of arachidonic acid secretion
GO:0090330 regulation of platelet aggregation
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0019815 B cell receptor complex
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032009 early phagosome
GO:0032991 macromolecular complex
GO:0042101 T cell receptor complex


-  Descriptions from all associated GenBank mRNAs
  AK075020 - Homo sapiens cDNA FLJ90539 fis, clone OVARC1000255, highly similar to Tyrosine-protein kinase SYK (EC 2.7.10.2).
E12042 - cDNA encoding human novel protein kinase.
Z29630 - H.sapiens syk mRNA for protein-tyrosine kinase.
BC001645 - Homo sapiens spleen tyrosine kinase, mRNA (cDNA clone MGC:2390 IMAGE:2959066), complete cds.
BC002962 - Homo sapiens spleen tyrosine kinase, mRNA (cDNA clone MGC:1604 IMAGE:3542895), complete cds.
L28824 - Homo sapiens protein tyrosine kinase (Syk) mRNA, complete cds.
AK290927 - Homo sapiens cDNA FLJ76165 complete cds, highly similar to Homo sapiens spleen tyrosine kinase (SYK), mRNA.
BC011399 - Homo sapiens spleen tyrosine kinase, mRNA (cDNA clone MGC:9504 IMAGE:3870426), complete cds.
X73568 - H.sapiens mRNA for protein tyrosin kinase.
JD417151 - Sequence 398175 from Patent EP1572962.
KJ897629 - Synthetic construct Homo sapiens clone ccsbBroadEn_07023 SYK gene, encodes complete protein.
CU679924 - Synthetic construct Homo sapiens gateway clone IMAGE:100019941 5' read SYK mRNA.
CU678314 - Synthetic construct Homo sapiens gateway clone IMAGE:100017439 5' read SYK mRNA.
KJ897630 - Synthetic construct Homo sapiens clone ccsbBroadEn_07024 SYK gene, encodes complete protein.
AB384797 - Synthetic construct DNA, clone: pF1KB3350, Homo sapiens SYK gene for tyrosine-protein kinase SYK, complete cds, without stop codon, in Flexi system.
FN391891 - Homo sapiens mRNA for spleen tyrosine kinase (SYK gene), clone Del714-717/Ins915-952.
FN391892 - Homo sapiens mRNA for spleen tyrosine kinase (SYK gene), clone Ins916-952.
FN391893 - Homo sapiens mRNA for spleen tyrosine kinase (SYK gene), clone Del714-717.
S80267 - p72syk {G insertion nucleotide 92} [human, Jurkat E6-1 J.CaM1 cells, mRNA Partial Mutant, 1909 nt].
BX647192 - Homo sapiens mRNA; cDNA DKFZp686B22244 (from clone DKFZp686B22244).
AK094808 - Homo sapiens cDNA FLJ37489 fis, clone BRAWH2014729.
AL832053 - Homo sapiens mRNA; cDNA DKFZp313N1010 (from clone DKFZp313N1010).
JD136567 - Sequence 117591 from Patent EP1572962.
JD047146 - Sequence 28170 from Patent EP1572962.
JD469675 - Sequence 450699 from Patent EP1572962.
JD546691 - Sequence 527715 from Patent EP1572962.
JD168894 - Sequence 149918 from Patent EP1572962.
JD133749 - Sequence 114773 from Patent EP1572962.
JD074342 - Sequence 55366 from Patent EP1572962.
JD258366 - Sequence 239390 from Patent EP1572962.
AK057772 - Homo sapiens cDNA FLJ25043 fis, clone CBL03441.
AJ420449 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1655597.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04650 - Natural killer cell mediated cytotoxicity
hsa04662 - B cell receptor signaling pathway
hsa04664 - Fc epsilon RI signaling pathway
hsa04666 - Fc gamma R-mediated phagocytosis

BioCarta from NCI Cancer Genome Anatomy Project
h_nkcellsPathway - Ras-Independent pathway in NK cell-mediated cytotoxicity
h_sppaPathway - Aspirin Blocks Signaling Pathway Involved in Platelet Activation
h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells
h_bcrPathway - BCR Signaling Pathway
h_il2Pathway - IL 2 signaling pathway
h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation

Reactome (by CSHL, EBI, and GO)

Protein P43405 (Reactome details) participates in the following event(s):

R-HSA-139842 Binding of Syk tyrosine kinase
R-HSA-210289 Recruitment of SYK to p-DAP12
R-HSA-429415 SYK binds to integrin alphaIIb beta3
R-HSA-508292 SYK binds IL2RB
R-HSA-983700 SYK binds the activated BCR
R-HSA-2029452 Recruitment of SYK to phosphorylated ITAMs
R-HSA-2454240 Recruitment of SYK to p-FCERI gamma subunit
R-HSA-5607738 SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan
R-NUL-5607748 SYK binds p-Y15-Clec7a:1,3-beta-D-glucan
R-HSA-5621366 SYK binds to p-Y65,Y76-FCER1G
R-HSA-5684801 p-Y7-CLEC1B dimer:PDPN binds SYK
R-HSA-437932 p-Y348-SYK binds VAV family
R-HSA-453183 p-Y348-SYK dissociates
R-HSA-2395412 Phosphorylation of SYK
R-HSA-429441 SYK activation by SRC
R-HSA-453200 SYK autophosphorylates
R-HSA-508282 SYK is a substrate for JAK1
R-HSA-983707 SYK autophosphorylates at the activated BCR
R-HSA-2029449 Phosphorylation of SYK by Src kinases
R-HSA-2454239 Phosphorylation of SYK
R-HSA-5621370 SYK autophosphorylates
R-HSA-879917 CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
R-HSA-437936 p-Y348-SYK phosphorylates VAV family
R-HSA-429449 Syk activation leads to SLP-76 activation
R-HSA-983703 p-6Y-SYK phosphorylates BLNK (SLP65)
R-HSA-2029270 Recruitment of PLCgamma to membrane
R-HSA-2029273 PI3K binds to p-6Y-SYK
R-HSA-2029458 Recruitment of VAV1 to p-6Y-SYK
R-HSA-2197697 Recruitment of CRKII:DOCK180:ELMO complex to FCGR
R-HSA-2029272 Release of PLCG from FCGR
R-HSA-2424482 p85 regulatory unit of PI3K binds p-6Y-SYK
R-HSA-5621356 PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G
R-HSA-5621347 PLCG2 translocates from cytosol to plasma membrane
R-HSA-5607745 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG
R-HSA-912629 CBL is tyrosine phosphorylated
R-HSA-434836 Syk/Lck phosphorylate LAT
R-HSA-2029453 Phosphorylation of VAV
R-HSA-2029268 Phosphorylation and activation of PLCG
R-HSA-2395801 Phosphorylation of LAT by p-SYK
R-HSA-2396594 Phosphorylation of SLP-76 by p-SYK
R-HSA-2424484 Phosphorylation of BTK by p-SYK
R-HSA-2424486 Phosphorylation and activation of VAV2/VAV3 by SYK
R-HSA-2424480 PI3K phosphorylates PIP2 to PIP3
R-HSA-2730833 Phosphorylation of TEC kinases by p-SYK
R-HSA-2730843 Phosphorylation of LAT by p-SYK
R-HSA-2730851 Phosphorylation of SLP-76 by p-SYK
R-HSA-2730884 Phosphorylation of NTAL by p-SYK/Lyn
R-HSA-2730886 Phosphorylation of SHC by SYK kinase
R-HSA-5621363 SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2
R-HSA-2029467 Activation of RAC1 by CRKII:DOCK180:ELMO
R-HSA-2029451 Activation of RAC1 by VAV
R-HSA-2029271 PI3K phosphorylates PIP2 to PIP3
R-HSA-2424487 Phosphorylation of PLC-gamma by p-BTK/p-SYK
R-HSA-2730860 Phosphorylation of GAB2 by SYK/FYN
R-HSA-2730888 Phosphorylation of PLC-gamma
R-HSA-1112666 BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
R-HSA-114604 GPVI-mediated activation cascade
R-HSA-2424491 DAP12 signaling
R-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-9020558 Interleukin-2 signaling
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-2029481 FCGR activation
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5621480 Dectin-2 family
R-HSA-912631 Regulation of signaling by CBL
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-2172127 DAP12 interactions
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-9006921 Integrin signaling
R-HSA-451927 Interleukin-2 family signaling
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-168249 Innate Immune System
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling
R-HSA-109582 Hemostasis
R-HSA-162582 Signal Transduction
R-HSA-449147 Signaling by Interleukins
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-1280215 Cytokine Signaling in Immune system

-  Other Names for This Gene
  Alternate Gene Symbols: BC011399, KSYK_HUMAN, P43405, uc004arb.1, uc004arb.2, uc004arb.3, uc004arb.4
UCSC ID: uc004arb.4
RefSeq Accession: NM_001174168
Protein: P43405 (aka KSYK_HUMAN)
CCDS: CCDS6688.1, CCDS47992.1

-  Methods, Credits, and Use Restrictions
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