Human Gene KIF3B (ENST00000375712.4) Description and Page Index
Description: Homo sapiens kinesin family member 3B (KIF3B), mRNA. (from RefSeq NM_004798) RefSeq Summary (NM_004798): The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB002357.1, SRR1660803.189755.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000375712.4/ ENSP00000364864.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Gencode Transcript: ENST00000375712.4 Gencode Gene: ENSG00000101350.8 Transcript (Including UTRs) Position: hg38 chr20:32,277,651-32,335,011 Size: 57,361 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr20:32,309,778-32,331,319 Size: 21,542 Coding Exon Count: 8
ID:KIF3B_HUMAN DESCRIPTION: RecName: Full=Kinesin-like protein KIF3B; AltName: Full=HH0048; AltName: Full=Microtubule plus end-directed kinesin motor 3B; FUNCTION: Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity). SUBUNIT: Heterodimer of KIF3A and KIF3B. Interacts directly with IFT20 (By similarity). Interacts with the SMC3 subunit of the cohesin complex. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable). SIMILARITY: Belongs to the kinesin-like protein family. Kinesin II subfamily. SIMILARITY: Contains 1 kinesin-motor domain. SEQUENCE CAUTION: Sequence=BAA20815.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O15066
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0007018 microtubule-based movement GO:0007052 mitotic spindle organization GO:0007100 mitotic centrosome separation GO:0007368 determination of left/right symmetry GO:0008089 anterograde axonal transport GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0032467 positive regulation of cytokinesis GO:0035735 intraciliary transport involved in cilium assembly GO:0072383 plus-end-directed vesicle transport along microtubule GO:0090307 mitotic spindle assembly