Human Gene KIF3B (ENST00000375712.4) Description and Page Index
  Description: Homo sapiens kinesin family member 3B (KIF3B), mRNA. (from RefSeq NM_004798)
RefSeq Summary (NM_004798): The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB002357.1, SRR1660803.189755.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000375712.4/ ENSP00000364864.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000375712.4
Gencode Gene: ENSG00000101350.8
Transcript (Including UTRs)
   Position: hg38 chr20:32,277,651-32,335,011 Size: 57,361 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg38 chr20:32,309,778-32,331,319 Size: 21,542 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr20:32,277,651-32,335,011)mRNA (may differ from genome)Protein (747 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Kinesin-like protein KIF3B; AltName: Full=HH0048; AltName: Full=Microtubule plus end-directed kinesin motor 3B;
FUNCTION: Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity).
SUBUNIT: Heterodimer of KIF3A and KIF3B. Interacts directly with IFT20 (By similarity). Interacts with the SMC3 subunit of the cohesin complex.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable).
SIMILARITY: Belongs to the kinesin-like protein family. Kinesin II subfamily.
SIMILARITY: Contains 1 kinesin-motor domain.
SEQUENCE CAUTION: Sequence=BAA20815.2; Type=Erroneous initiation;

-  MalaCards Disease Associations
  MalaCards Gene Search: KIF3B
Diseases sorted by gene-association score: tuberculous peritonitis (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.60 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 556.78 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -70.40180-0.391 Picture PostScript Text
3' UTR -1130.103692-0.306 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019821 - Kinesin_motor_CS
IPR001752 - Kinesin_motor_dom

Pfam Domains:
PF00225 - Kinesin motor domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on O15066
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl WormBase 
Protein SequenceProtein Sequence  Protein Sequence 
AlignmentAlignment  Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed
GO:0017048 Rho GTPase binding

Biological Process:
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0007018 microtubule-based movement
GO:0007052 mitotic spindle organization
GO:0007100 mitotic centrosome separation
GO:0007368 determination of left/right symmetry
GO:0008089 anterograde axonal transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032467 positive regulation of cytokinesis
GO:0035735 intraciliary transport involved in cilium assembly
GO:0072383 plus-end-directed vesicle transport along microtubule
GO:0090307 mitotic spindle assembly

Cellular Component:
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005873 plus-end kinesin complex
GO:0005874 microtubule
GO:0005929 cilium
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0016939 kinesin II complex
GO:0030424 axon
GO:0030496 midbody
GO:0030990 intraciliary transport particle
GO:0042995 cell projection
GO:0070062 extracellular exosome
GO:0097542 ciliary tip
GO:1904115 axon cytoplasm
GO:0005876 spindle microtubule

-  Descriptions from all associated GenBank mRNAs
  AK302403 - Homo sapiens cDNA FLJ61470 complete cds, highly similar to Kinesin-like protein KIF3B.
AB002357 - Homo sapiens mRNA for KIAA0359 gene.
JD336848 - Sequence 317872 from Patent EP1572962.
JD458325 - Sequence 439349 from Patent EP1572962.
JD054749 - Sequence 35773 from Patent EP1572962.
JD389863 - Sequence 370887 from Patent EP1572962.
BC136310 - Homo sapiens kinesin family member 3B, mRNA (cDNA clone MGC:167920 IMAGE:9020297), complete cds.
BC136311 - Homo sapiens kinesin family member 3B, mRNA (cDNA clone MGC:167921 IMAGE:9020298), complete cds.
AB383859 - Synthetic construct DNA, clone: pF1KSDA0359, Homo sapiens KIF3B gene for kinesin family member 3B, complete cds, without stop codon, in Flexi system.
AK299877 - Homo sapiens cDNA FLJ55620 complete cds, highly similar to Kinesin-like protein KIF3B.
DQ579680 - Homo sapiens piRNA piR-47792, complete sequence.
AK098431 - Homo sapiens cDNA FLJ25565 fis, clone JTH03160, highly similar to KINESIN-LIKE PROTEIN KIF3B.
JD184622 - Sequence 165646 from Patent EP1572962.
JD167358 - Sequence 148382 from Patent EP1572962.
JD263040 - Sequence 244064 from Patent EP1572962.
JD096141 - Sequence 77165 from Patent EP1572962.
JD521499 - Sequence 502523 from Patent EP1572962.
JD431738 - Sequence 412762 from Patent EP1572962.
JD195452 - Sequence 176476 from Patent EP1572962.
JD402859 - Sequence 383883 from Patent EP1572962.
JD164646 - Sequence 145670 from Patent EP1572962.
JD389632 - Sequence 370656 from Patent EP1572962.
JD253706 - Sequence 234730 from Patent EP1572962.
JD393731 - Sequence 374755 from Patent EP1572962.
JD282339 - Sequence 263363 from Patent EP1572962.
JD231088 - Sequence 212112 from Patent EP1572962.
JD403862 - Sequence 384886 from Patent EP1572962.
JD171334 - Sequence 152358 from Patent EP1572962.
JD556837 - Sequence 537861 from Patent EP1572962.
JD113461 - Sequence 94485 from Patent EP1572962.
JD101708 - Sequence 82732 from Patent EP1572962.
JD496387 - Sequence 477411 from Patent EP1572962.
JD259488 - Sequence 240512 from Patent EP1572962.
JD206441 - Sequence 187465 from Patent EP1572962.
JD110793 - Sequence 91817 from Patent EP1572962.
JD436457 - Sequence 417481 from Patent EP1572962.
JD449335 - Sequence 430359 from Patent EP1572962.
JD441858 - Sequence 422882 from Patent EP1572962.
JD376175 - Sequence 357199 from Patent EP1572962.
JD332961 - Sequence 313985 from Patent EP1572962.
JD184837 - Sequence 165861 from Patent EP1572962.
JD074059 - Sequence 55083 from Patent EP1572962.
JD137517 - Sequence 118541 from Patent EP1572962.
JD543465 - Sequence 524489 from Patent EP1572962.
JD023509 - Sequence 4533 from Patent EP1572962.
JD034426 - Sequence 15450 from Patent EP1572962.
JD232447 - Sequence 213471 from Patent EP1572962.
JD385708 - Sequence 366732 from Patent EP1572962.
JD173818 - Sequence 154842 from Patent EP1572962.
JD532076 - Sequence 513100 from Patent EP1572962.
JD310382 - Sequence 291406 from Patent EP1572962.
JD483780 - Sequence 464804 from Patent EP1572962.
JD080987 - Sequence 62011 from Patent EP1572962.
JD427176 - Sequence 408200 from Patent EP1572962.
JD466000 - Sequence 447024 from Patent EP1572962.
JD371879 - Sequence 352903 from Patent EP1572962.
JD206757 - Sequence 187781 from Patent EP1572962.
JD433508 - Sequence 414532 from Patent EP1572962.
JD466869 - Sequence 447893 from Patent EP1572962.
JD144864 - Sequence 125888 from Patent EP1572962.
JD521192 - Sequence 502216 from Patent EP1572962.
JD396039 - Sequence 377063 from Patent EP1572962.
JD219385 - Sequence 200409 from Patent EP1572962.
JD481465 - Sequence 462489 from Patent EP1572962.
JD179784 - Sequence 160808 from Patent EP1572962.
JD128120 - Sequence 109144 from Patent EP1572962.
JD128121 - Sequence 109145 from Patent EP1572962.
JD344248 - Sequence 325272 from Patent EP1572962.
JD231515 - Sequence 212539 from Patent EP1572962.
JD422074 - Sequence 403098 from Patent EP1572962.
JD266591 - Sequence 247615 from Patent EP1572962.
JD158910 - Sequence 139934 from Patent EP1572962.
JD208702 - Sequence 189726 from Patent EP1572962.
JD145810 - Sequence 126834 from Patent EP1572962.
JD334122 - Sequence 315146 from Patent EP1572962.
JD438861 - Sequence 419885 from Patent EP1572962.
JD112100 - Sequence 93124 from Patent EP1572962.
JD488584 - Sequence 469608 from Patent EP1572962.
JD377039 - Sequence 358063 from Patent EP1572962.
JD224614 - Sequence 205638 from Patent EP1572962.
JD455037 - Sequence 436061 from Patent EP1572962.
JD378177 - Sequence 359201 from Patent EP1572962.
JD175477 - Sequence 156501 from Patent EP1572962.
JD331451 - Sequence 312475 from Patent EP1572962.
JD181755 - Sequence 162779 from Patent EP1572962.
JD082514 - Sequence 63538 from Patent EP1572962.
JD503400 - Sequence 484424 from Patent EP1572962.
JD072615 - Sequence 53639 from Patent EP1572962.
JD295401 - Sequence 276425 from Patent EP1572962.
JD428752 - Sequence 409776 from Patent EP1572962.
JD271352 - Sequence 252376 from Patent EP1572962.
JD503451 - Sequence 484475 from Patent EP1572962.
JD287024 - Sequence 268048 from Patent EP1572962.
JD172343 - Sequence 153367 from Patent EP1572962.
JD418883 - Sequence 399907 from Patent EP1572962.
JD161942 - Sequence 142966 from Patent EP1572962.
JD131440 - Sequence 112464 from Patent EP1572962.
JD252229 - Sequence 233253 from Patent EP1572962.
JD344627 - Sequence 325651 from Patent EP1572962.
JD224749 - Sequence 205773 from Patent EP1572962.
JD448086 - Sequence 429110 from Patent EP1572962.
JD255904 - Sequence 236928 from Patent EP1572962.
JD426172 - Sequence 407196 from Patent EP1572962.
JD074881 - Sequence 55905 from Patent EP1572962.
JD405050 - Sequence 386074 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O15066 (Reactome details) participates in the following event(s):

R-HSA-2316347 RAB4A:GTP binds KIF3 and activates KIF3
R-HSA-984708 Kinesin-2 is a heterotrimer
R-HSA-984733 Kinesin-3 is a dimer
R-HSA-983266 Kinesins bind microtubules
R-HSA-5625424 The retrograde IFT train dissociates
R-HSA-5624952 Assembly of the retrograde IFT train
R-HSA-5625421 The anterograde IFT train dissociates
R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules
R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs
R-HSA-5624949 Assembly of the anterograde IFT train
R-HSA-1445148 Translocation of GLUT4 to the plasma membrane
R-HSA-983189 Kinesins
R-HSA-199991 Membrane Trafficking
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-5653656 Vesicle-mediated transport
R-HSA-109582 Hemostasis
R-HSA-5620924 Intraflagellar transport
R-HSA-2132295 MHC class II antigen presentation
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-5617833 Cilium Assembly
R-HSA-1280218 Adaptive Immune System
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-168256 Immune System
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic

-  Other Names for This Gene
  Alternate Gene Symbols: B2RMP4, E1P5M5, KIAA0359, KIF3B_HUMAN, NM_004798, O15066, uc002wxq.1, uc002wxq.2, uc002wxq.3, uc002wxq.4, uc002wxq.5
UCSC ID: uc002wxq.5
RefSeq Accession: NM_004798
Protein: O15066 (aka KIF3B_HUMAN or KF3B_HUMAN)
CCDS: CCDS13200.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.