Human Gene C10orf53 (ENST00000374113.3) Description and Page Index
  Description: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8N6V4-1; Sequence=Displayed; Note=No experimental confirmation available; Name=2; IsoId=Q8N6V4-2; Sequence=VSP_036509; Note=No experimental confirmation available; Name=3; IsoId=Q8N6V4-3; Sequence=VSP_036867; Note=No experimental confirmation available; (from UniProt Q8N6V4)
Gencode Transcript: ENST00000374113.3
Gencode Gene: ENSG00000178645.13
Transcript (Including UTRs)
   Position: hg38 chr10:49,679,651-49,696,044 Size: 16,394 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr10:49,679,698-49,693,958 Size: 14,261 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:49,679,651-49,696,044)mRNA (may differ from genome)Protein (93 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblExonPrimerGeneCardsHGNCLynxMGI
neXtProtPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CJ053_HUMAN
DESCRIPTION: RecName: Full=UPF0728 protein C10orf53;
SIMILARITY: Belongs to the UPF0728 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.03 RPKM in Testis
Total median expression: 3.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -18.6047-0.396 Picture PostScript Text
3' UTR -569.142086-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q8N6V4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AK296108 - Homo sapiens cDNA FLJ60598 complete cds, highly similar to Choline O-acetyltransferase (EC 2.3.1.6).
AK091773 - Homo sapiens cDNA FLJ34454 fis, clone HLUNG2002562.
AX747176 - Sequence 701 from Patent EP1308459.
BC028127 - Homo sapiens chromosome 10 open reading frame 53, mRNA (cDNA clone MGC:40171 IMAGE:5164374), complete cds.
KJ900538 - Synthetic construct Homo sapiens clone ccsbBroadEn_09932 C10orf53 gene, encodes complete protein.
JD372119 - Sequence 353143 from Patent EP1572962.
JD385650 - Sequence 366674 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NI81, A6NLE0, AK091773, CJ053_HUMAN, Q8N6V4, uc001jic.1, uc001jic.2
UCSC ID: uc001jic.2
RefSeq Accession: NM_001042427
Protein: Q8N6V4 (aka CJ053_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.