Human Gene SEMG1 (ENST00000372781.4) Description and Page Index
Description: Homo sapiens semenogelin 1 (SEMG1), mRNA. (from RefSeq NM_003007) RefSeq Summary (NM_003007): The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. This preproprotein is proteolytically processed by the prostate-specific antigen (PSA) protease to generate multiple peptide products that exhibit distinct functions. One of these peptides, SgI-29, is an antimicrobial peptide with antibacterial activity. This proteolysis process also breaks down the gel matrix and allows the spermatozoa to move more freely. This gene and another similar semenogelin gene are present in a gene cluster on chromosome 20. [provided by RefSeq, Feb 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J04440.1, ERR279869.434.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2156266, SAMEA2159912 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000372781.4/ ENSP00000361867.3 Protein has antimicrobial activity :: PMID: 18314226 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Gencode Transcript: ENST00000372781.4 Gencode Gene: ENSG00000124233.12 Transcript (Including UTRs) Position: hg38 chr20:45,207,033-45,209,768 Size: 2,736 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr20:45,207,054-45,208,686 Size: 1,633 Coding Exon Count: 2
ID:SEMG1_HUMAN DESCRIPTION: RecName: Full=Semenogelin-1; AltName: Full=Semenogelin I; Short=SGI; Contains: RecName: Full=Alpha-inhibin-92; Contains: RecName: Full=Alpha-inhibin-31; Contains: RecName: Full=Seminal basic protein; Flags: Precursor; FUNCTION: Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA. FUNCTION: Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone. SUBUNIT: Occurs in disulfide-linked complexes which may also contain two less abundant 71- and 76-kDa semenogelin-related polypeptides. Interacts with EPPIN (via C-terminus); Cys-239 is a critical amino acid for both binding to EPPIN. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Seminal vesicle. PTM: Transglutaminase substrate. PTM: Rapidly cleaved after ejaculation by KLK3/PSA, resulting in liquefaction of the semen coagulum and the progressive release of motile spermatozoa. SIMILARITY: Belongs to the semenogelin family. WEB RESOURCE: Name=Protein Spotlight; Note=Shackled sperm - Issue 62 of September 2005; URL="http://web.expasy.org/spotlight/back_issues/sptlt062.shtml";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P04279
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.