Human Gene UBE2V1 (ENST00000371674.7) Description and Page Index
Description: Homo sapiens ubiquitin conjugating enzyme E2 V1 (UBE2V1), transcript variant 15, mRNA. (from RefSeq NM_001282577) RefSeq Summary (NM_001282579): Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]. Gencode Transcript: ENST00000371674.7 Gencode Gene: ENSG00000244687.11 Transcript (Including UTRs) Position: hg38 chr20:50,081,124-50,113,173 Size: 32,050 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr20:50,082,768-50,113,128 Size: 30,361 Coding Exon Count: 4
ID:UB2V1_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-conjugating enzyme E2 variant 1; Short=UEV-1; AltName: Full=CROC-1; AltName: Full=TRAF6-regulated IKK activator 1 beta Uev1A; FUNCTION: Has no ubiquitin ligase activity on its own. The UBE2V1- UBE2N heterodimer catalyzes the synthesis of non-canonical poly- ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. SUBUNIT: Heterodimer with UBE2N. Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity. Interacts with TRAF6. INTERACTION: P61088:UBE2N; NbExp=9; IntAct=EBI-1050671, EBI-1052908; P98170:XIAP; NbExp=2; IntAct=EBI-1050671, EBI-517127; Q8ND25:ZNRF1; NbExp=2; IntAct=EBI-1050671, EBI-2129250; SUBCELLULAR LOCATION: Nucleus. Note=Excluded from the nucleolus. TISSUE SPECIFICITY: Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung. INDUCTION: Down-regulated during differentiation of cultured colon adenocarcinoma cells. MISCELLANEOUS: In human, TMEM189/KUA and UBE2V1/UEV1 are adjacent genes which can produce independent proteins and can also be fused to form a TMEM189-UBE2V1 hybrid protein. SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. SEQUENCE CAUTION: Sequence=AAH08944.2; Type=Erroneous initiation; Sequence=CAC16955.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13404
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
R-HSA-202453 Auto-ubiquitination of TRAF6 R-HSA-937050 Pellino ubiquitinates hp-IRAK1 R-HSA-975118 TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation R-HSA-975122 Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation