Human Gene UBE2V1 (ENST00000371674.7) Description and Page Index
  Description: Homo sapiens ubiquitin conjugating enzyme E2 V1 (UBE2V1), transcript variant 15, mRNA. (from RefSeq NM_001282577)
RefSeq Summary (NM_001282579): Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012].
Gencode Transcript: ENST00000371674.7
Gencode Gene: ENSG00000244687.11
Transcript (Including UTRs)
   Position: hg38 chr20:50,081,124-50,113,173 Size: 32,050 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr20:50,082,768-50,113,128 Size: 30,361 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr20:50,081,124-50,113,173)mRNA (may differ from genome)Protein (147 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Ubiquitin-conjugating enzyme E2 variant 1; Short=UEV-1; AltName: Full=CROC-1; AltName: Full=TRAF6-regulated IKK activator 1 beta Uev1A;
FUNCTION: Has no ubiquitin ligase activity on its own. The UBE2V1- UBE2N heterodimer catalyzes the synthesis of non-canonical poly- ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
SUBUNIT: Heterodimer with UBE2N. Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity. Interacts with TRAF6.
INTERACTION: P61088:UBE2N; NbExp=9; IntAct=EBI-1050671, EBI-1052908; P98170:XIAP; NbExp=2; IntAct=EBI-1050671, EBI-517127; Q8ND25:ZNRF1; NbExp=2; IntAct=EBI-1050671, EBI-2129250;
SUBCELLULAR LOCATION: Nucleus. Note=Excluded from the nucleolus.
TISSUE SPECIFICITY: Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung.
INDUCTION: Down-regulated during differentiation of cultured colon adenocarcinoma cells.
MISCELLANEOUS: In human, TMEM189/KUA and UBE2V1/UEV1 are adjacent genes which can produce independent proteins and can also be fused to form a TMEM189-UBE2V1 hybrid protein.
SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
SEQUENCE CAUTION: Sequence=AAH08944.2; Type=Erroneous initiation; Sequence=CAC16955.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.79 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 68.70 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.7045-0.171 Picture PostScript Text
3' UTR -405.401644-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000608 - UBQ-conjugat_E2
IPR016135 - UBQ-conjugating_enzyme/RWD

Pfam Domains:
PF00179 - Ubiquitin-conjugating enzyme

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

- X-ray


ModBase Predicted Comparative 3D Structure on Q13404
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0061630 ubiquitin protein ligase activity

Biological Process:
GO:0000187 activation of MAPK activity
GO:0000209 protein polyubiquitination
GO:0006282 regulation of DNA repair
GO:0006301 postreplication repair
GO:0006355 regulation of transcription, DNA-templated
GO:0007254 JNK cascade
GO:0030154 cell differentiation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070534 protein K63-linked ubiquitination

Cellular Component:
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031371 ubiquitin conjugating enzyme complex
GO:0032991 macromolecular complex
GO:0035370 UBC13-UEV1A complex
GO:0070062 extracellular exosome

-  Descriptions from all associated GenBank mRNAs
  U49278 - Homo sapiens UEV-1 (UBE2V) mRNA, partial cds.
BX647511 - Homo sapiens mRNA; cDNA DKFZp686I21199 (from clone DKFZp686I21199).
BX648147 - Homo sapiens mRNA; cDNA DKFZp686G1080 (from clone DKFZp686G1080).
U97279 - Homo sapiens UEV-1 (UBE2V) alternatively spliced incompletely processed mRNA, partial cds.
AL110132 - Homo sapiens mRNA; cDNA DKFZp564H192 (from clone DKFZp564H192).
JD557645 - Sequence 538669 from Patent EP1572962.
AF049671 - Homo sapiens clone CIR1 cell immortalization-related mRNA sequence.
U39360 - Homo sapiens DNA-binding protein (CROC-1A) mRNA, complete cds.
U39361 - Homo sapiens DNA-binding protein (CROC-1B) mRNA, complete cds.
BC008944 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 1, mRNA (cDNA clone IMAGE:2960953), partial cds.
BC000468 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 1, mRNA (cDNA clone MGC:8586 IMAGE:2961017), complete cds.
JD273306 - Sequence 254330 from Patent EP1572962.
JD101605 - Sequence 82629 from Patent EP1572962.
JD315254 - Sequence 296278 from Patent EP1572962.
JD558001 - Sequence 539025 from Patent EP1572962.
JD272684 - Sequence 253708 from Patent EP1572962.
JD299451 - Sequence 280475 from Patent EP1572962.
DQ598317 - Homo sapiens piRNA piR-36383, complete sequence.
JD269185 - Sequence 250209 from Patent EP1572962.
JD133135 - Sequence 114159 from Patent EP1572962.
JD104747 - Sequence 85771 from Patent EP1572962.
JD192643 - Sequence 173667 from Patent EP1572962.
JD247296 - Sequence 228320 from Patent EP1572962.
JD413564 - Sequence 394588 from Patent EP1572962.
JD324264 - Sequence 305288 from Patent EP1572962.
JD240731 - Sequence 221755 from Patent EP1572962.
JD083928 - Sequence 64952 from Patent EP1572962.
JD110278 - Sequence 91302 from Patent EP1572962.
JD202857 - Sequence 183881 from Patent EP1572962.
JD377384 - Sequence 358408 from Patent EP1572962.
JD320567 - Sequence 301591 from Patent EP1572962.
JD391827 - Sequence 372851 from Patent EP1572962.
JD433549 - Sequence 414573 from Patent EP1572962.
JD272706 - Sequence 253730 from Patent EP1572962.
JD403675 - Sequence 384699 from Patent EP1572962.
JD253152 - Sequence 234176 from Patent EP1572962.
JD297643 - Sequence 278667 from Patent EP1572962.
JD218720 - Sequence 199744 from Patent EP1572962.
JD054937 - Sequence 35961 from Patent EP1572962.
JD498860 - Sequence 479884 from Patent EP1572962.
JD498861 - Sequence 479885 from Patent EP1572962.
JD241200 - Sequence 222224 from Patent EP1572962.
JD460143 - Sequence 441167 from Patent EP1572962.
JD261094 - Sequence 242118 from Patent EP1572962.
JD228794 - Sequence 209818 from Patent EP1572962.
JD488233 - Sequence 469257 from Patent EP1572962.
JD268228 - Sequence 249252 from Patent EP1572962.
JD061124 - Sequence 42148 from Patent EP1572962.
BC005215 - Homo sapiens cDNA clone IMAGE:3996506.
U97280 - Homo sapiens UEV1Bs (UBE2V) mRNA, alternatively spliced, partial cds.
AY008273 - Homo sapiens TRAF6-regulated IKK activator 1 beta Uev1A mRNA, complete cds.
U97281 - Homo sapiens UEV1As (UBE2V) mRNA, alternatively spliced, complete cds.
AK314754 - Homo sapiens cDNA, FLJ95620.
BT007382 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 1 mRNA, complete cds.
CU674232 - Synthetic construct Homo sapiens gateway clone IMAGE:100017928 5' read UBE2V1 mRNA.
HQ448675 - Synthetic construct Homo sapiens clone IMAGE:100072117; CCSB004673_01 ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) gene, encodes complete protein.
KJ892347 - Synthetic construct Homo sapiens clone ccsbBroadEn_01741 UBE2V1 gene, encodes complete protein.
BC172339 - Synthetic construct Homo sapiens clone IMAGE:100069033, MGC:199044 TMEM189-UBE2V1 readthrough transcript (TMEM189-UBE2V1) mRNA, encodes complete protein.
AB587452 - Synthetic construct DNA, clone: pF1KB7917, Homo sapiens TMEM189-UBE2V1 gene for TMEM189-UBE2V1 readthrough, without stop codon, in Flexi system.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-7511 - protein ubiquitylation

Reactome (by CSHL, EBI, and GO)

Protein Q13404 (Reactome details) participates in the following event(s):

R-HSA-202453 Auto-ubiquitination of TRAF6
R-HSA-937050 Pellino ubiquitinates hp-IRAK1
R-HSA-975118 TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation
R-HSA-975122 Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation

R-HSA-8948015 hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb
R-HSA-983152 Transfer of ubiquitin from E1 to E2
R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2
R-HSA-446877 TRAF6 is K63 poly-ubiquitinated
R-HSA-451418 Pellino ubiquitinates IRAK1
R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex
R-HSA-741386 RIP2 induces K63-linked ubiquitination of NEMO
R-HSA-688137 RIP2 is K63 polyubiquitinated
R-HSA-168915 K63-linked ubiquitination of RIP1 bound to the activated TLR complex
R-HSA-9014342 K63-linked ubiquitination of RIP1 bound to the activated TLR complex
R-HSA-168184 Activated TAK1 mediates phosphorylation of the IKK Complex
R-HSA-450337 Activated TAK1 phosphorylates MKK4/MKK7
R-HSA-450346 activated human TAK1 phosphorylates MKK3/MKK6
R-HSA-202424 Downstream TCR signaling
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-937039 IRAK1 recruits IKK complex
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-HSA-9020702 Interleukin-1 signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-202403 TCR signaling
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-446652 Interleukin-1 family signaling
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-1280218 Adaptive Immune System
R-HSA-168249 Innate Immune System
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-449147 Signaling by Interleukins
R-HSA-937041 IKK complex recruitment mediated by RIP1
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-168256 Immune System
R-HSA-168898 Toll-Like Receptors Cascades
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-450302 activated TAK1 mediates p38 MAPK activation
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-450294 MAP kinase activation
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-448424 Interleukin-17 signaling

-  Other Names for This Gene
  Alternate Gene Symbols: CROC1, E1P629, NM_001282577, P/OKcl.19, Q13403, Q13404, Q13532, Q5TGE3, Q96H34, Q9GZT0, Q9GZW1, Q9H4J3, Q9H4J4, Q9UKL1, Q9UM48, Q9UM49, Q9UM50, UB2V1_HUMAN, UBE2V, uc002xva.1, uc002xva.2, uc002xva.3, uc002xva.4, uc002xva.5, UEV1
UCSC ID: uc002xva.5
RefSeq Accession: NM_001282579
Protein: Q13404 (aka UB2V1_HUMAN or U2V1_HUMAN)
CCDS: CCDS33483.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.