Human Gene WLS (ENST00000370971.1) Description and Page Index
  Description: wntless Wnt ligand secretion mediator (from HGNC WLS)
Gencode Transcript: ENST00000370971.1
Gencode Gene: ENSG00000116729.14
Transcript (Including UTRs)
   Position: hg38 chr1:68,193,858-68,232,523 Size: 38,666 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr1:68,193,950-68,232,299 Size: 38,350 Coding Exon Count: 2 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:68,193,858-68,232,523)mRNA (may differ from genome)Protein (127 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: WLS
Diseases sorted by gene-association score: chromosome 1p32-p31 deletion syndrome (3), chronic intestinal vascular insufficiency (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 48.64 RPKM in Esophagus - Gastroesophageal Junction
Total median expression: 826.72 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -89.90224-0.401 Picture PostScript Text
3' UTR -10.0092-0.109 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009551 - wntless

ModBase Predicted Comparative 3D Structure on Q7Z430
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0017147 Wnt-protein binding

Biological Process:
GO:0016055 Wnt signaling pathway

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AK301613 - Homo sapiens cDNA FLJ54765 complete cds.
BX538320 - Homo sapiens mRNA; cDNA DKFZp686K06169 (from clone DKFZp686K06169).
DQ323735 - Homo sapiens wntless protein (WLS) mRNA, complete cds.
AK074984 - Homo sapiens cDNA FLJ90503 fis, clone NT2RP3004083, highly similar to Putative NFkB activating protein 373.
AY359035 - Homo sapiens clone DNA44174 AGAI857 (UNQ857) mRNA, complete cds.
BC007211 - Homo sapiens G protein-coupled receptor 177, mRNA (cDNA clone IMAGE:3349207), partial cds.
BC110826 - Homo sapiens G protein-coupled receptor 177, mRNA (cDNA clone MGC:131760 IMAGE:6183768), complete cds.
BX648748 - Homo sapiens mRNA; cDNA DKFZp686G1457 (from clone DKFZp686G1457).
AK074990 - Homo sapiens cDNA FLJ90509 fis, clone NT2RP3004294, weakly similar to Xenopus laevis ER1 mRNA.
AK074583 - Homo sapiens cDNA FLJ90102 fis, clone HEMBA1006299, highly similar to Putative NFkB activating protein 373.
BC137109 - Homo sapiens G protein-coupled receptor 177, mRNA (cDNA clone MGC:168729 IMAGE:9021106), complete cds.
BC137113 - Homo sapiens G protein-coupled receptor 177, mRNA (cDNA clone MGC:168733 IMAGE:9021110), complete cds.
AK309779 - Homo sapiens cDNA, FLJ99820.
KJ903257 - Synthetic construct Homo sapiens clone ccsbBroadEn_12651 WLS gene, encodes complete protein.
CU675559 - Synthetic construct Homo sapiens gateway clone IMAGE:100019417 5' read GPR177 mRNA.
AB097018 - Homo sapiens mRNA for putative NFkB activating protein, complete cds, clone: 373.
JD076225 - Sequence 57249 from Patent EP1572962.
JD381955 - Sequence 362979 from Patent EP1572962.
JD143209 - Sequence 124233 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AB097018, GPR177, Q7Z430, Q7Z430_HUMAN, RP11-518D3.2-004, uc001deh.1, uc001deh.2, uc001deh.3
UCSC ID: uc001deh.3
RefSeq Accession: NM_024911
Protein: Q7Z430

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.