Human Gene SRPK3 (ENST00000370101.8) Description and Page Index
  Description: Homo sapiens SRSF protein kinase 3 (SRPK3), transcript variant 1, mRNA. (from RefSeq NM_014370)
RefSeq Summary (NM_014370): This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].
Gencode Transcript: ENST00000370101.8
Gencode Gene: ENSG00000184343.11
Transcript (Including UTRs)
   Position: hg38 chrX:153,781,041-153,785,730 Size: 4,690 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg38 chrX:153,781,087-153,785,520 Size: 4,434 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:153,781,041-153,785,730)mRNA (may differ from genome)Protein (567 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
HGNCHPRDLynxMGImyGene2neXtProt
OMIMPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: SRPK3_HUMAN
DESCRIPTION: RecName: Full=SRSF protein kinase 3; EC=2.7.11.1; AltName: Full=Muscle-specific serine kinase 1; Short=MSSK-1; AltName: Full=Serine/arginine-rich protein-specific kinase 3; Short=SR-protein-specific kinase 3; AltName: Full=Serine/threonine-protein kinase 23;
FUNCTION: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
TISSUE SPECIFICITY: Exclusively expressed in skeletal and heart muscle.
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
SIMILARITY: Contains 1 protein kinase domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.75 RPKM in Muscle - Skeletal
Total median expression: 173.36 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.5046-0.489 Picture PostScript Text
3' UTR -82.90210-0.395 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain

ModBase Predicted Comparative 3D Structure on Q9UPE1
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0000245 spliceosomal complex assembly
GO:0006468 protein phosphorylation
GO:0007275 multicellular organism development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0016310 phosphorylation
GO:0030154 cell differentiation
GO:0035556 intracellular signal transduction
GO:0050684 regulation of mRNA processing
GO:0060537 muscle tissue development

Cellular Component:
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AB209155 - Homo sapiens mRNA for serine/threonine kinase 23 variant protein.
BC117124 - Homo sapiens SFRS protein kinase 3, mRNA (cDNA clone MGC:150733 IMAGE:40125675), complete cds.
AK314828 - Homo sapiens cDNA, FLJ95709.
AK301749 - Homo sapiens cDNA FLJ58116 complete cds, highly similar to Homo sapiens serine/threonine kinase 23 (STK23), mRNA.
BC092416 - Homo sapiens SFRS protein kinase 3, mRNA (cDNA clone MGC:102944 IMAGE:30529915), complete cds.
AF027406 - Homo sapiens muscle-specific serine kinase 1 (MSSK1) mRNA, complete cds.
AB489184 - Synthetic construct DNA, clone: pF1KB5980, Homo sapiens SRPK3 gene for SFRS protein kinase 3, without stop codon, in Flexi system.
HQ258470 - Synthetic construct Homo sapiens clone IMAGE:100072899 Unknown protein gene, encodes complete protein.
KJ898635 - Synthetic construct Homo sapiens clone ccsbBroadEn_08029 SRPK3 gene, encodes complete protein.
DQ099381 - Homo sapiens serine/threonine kinase 23 mRNA, complete cds, alternatively spliced.
U82808 - Homo sapiens muscle-specific serine kinase 1 (MSSK1) mRNA, complete cds.
JD390325 - Sequence 371349 from Patent EP1572962.
JD126493 - Sequence 107517 from Patent EP1572962.
JD278248 - Sequence 259272 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: MSSK1, NM_014370, Q13583, Q4F970, Q562F5, Q9UM62, Q9UPE1, SRPK3_HUMAN, STK23, uc004fil.1, uc004fil.2, uc004fil.3, uc004fil.4, uc004fil.5
UCSC ID: uc004fil.5
RefSeq Accession: NM_014370
Protein: Q9UPE1 (aka SRPK3_HUMAN)
CCDS: CCDS35441.1, CCDS55538.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.