Human Gene SRPK3 (ENST00000370101.8) Description and Page Index
  Description: Homo sapiens SRSF protein kinase 3 (SRPK3), transcript variant 1, mRNA. (from RefSeq NM_014370)
RefSeq Summary (NM_014370): This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].
Gencode Transcript: ENST00000370101.8
Gencode Gene: ENSG00000184343.11
Transcript (Including UTRs)
   Position: hg38 chrX:153,781,041-153,785,730 Size: 4,690 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg38 chrX:153,781,087-153,785,520 Size: 4,434 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrX:153,781,041-153,785,730)mRNA (may differ from genome)Protein (567 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
OMIMPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=SRSF protein kinase 3; EC=; AltName: Full=Muscle-specific serine kinase 1; Short=MSSK-1; AltName: Full=Serine/arginine-rich protein-specific kinase 3; Short=SR-protein-specific kinase 3; AltName: Full=Serine/threonine-protein kinase 23;
FUNCTION: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
TISSUE SPECIFICITY: Exclusively expressed in skeletal and heart muscle.
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
SIMILARITY: Contains 1 protein kinase domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.75 RPKM in Muscle - Skeletal
Total median expression: 173.36 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.5046-0.489 Picture PostScript Text
3' UTR -82.90210-0.395 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain

ModBase Predicted Comparative 3D Structure on Q9UPE1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0000245 spliceosomal complex assembly
GO:0006468 protein phosphorylation
GO:0007275 multicellular organism development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0016310 phosphorylation
GO:0030154 cell differentiation
GO:0035556 intracellular signal transduction
GO:0050684 regulation of mRNA processing
GO:0060537 muscle tissue development

Cellular Component:
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  AB209155 - Homo sapiens mRNA for serine/threonine kinase 23 variant protein.
BC117124 - Homo sapiens SFRS protein kinase 3, mRNA (cDNA clone MGC:150733 IMAGE:40125675), complete cds.
AK314828 - Homo sapiens cDNA, FLJ95709.
AK301749 - Homo sapiens cDNA FLJ58116 complete cds, highly similar to Homo sapiens serine/threonine kinase 23 (STK23), mRNA.
BC092416 - Homo sapiens SFRS protein kinase 3, mRNA (cDNA clone MGC:102944 IMAGE:30529915), complete cds.
AF027406 - Homo sapiens muscle-specific serine kinase 1 (MSSK1) mRNA, complete cds.
AB489184 - Synthetic construct DNA, clone: pF1KB5980, Homo sapiens SRPK3 gene for SFRS protein kinase 3, without stop codon, in Flexi system.
HQ258470 - Synthetic construct Homo sapiens clone IMAGE:100072899 Unknown protein gene, encodes complete protein.
KJ898635 - Synthetic construct Homo sapiens clone ccsbBroadEn_08029 SRPK3 gene, encodes complete protein.
DQ099381 - Homo sapiens serine/threonine kinase 23 mRNA, complete cds, alternatively spliced.
U82808 - Homo sapiens muscle-specific serine kinase 1 (MSSK1) mRNA, complete cds.
JD390325 - Sequence 371349 from Patent EP1572962.
JD126493 - Sequence 107517 from Patent EP1572962.
JD278248 - Sequence 259272 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: MSSK1, NM_014370, Q13583, Q4F970, Q562F5, Q9UM62, Q9UPE1, SRPK3_HUMAN, STK23, uc004fil.1, uc004fil.2, uc004fil.3, uc004fil.4, uc004fil.5
UCSC ID: uc004fil.5
RefSeq Accession: NM_014370
Protein: Q9UPE1 (aka SRPK3_HUMAN)
CCDS: CCDS35441.1, CCDS55538.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.