Human Gene RUSC1 (ENST00000368352.10) Description and Page Index
  Description: Homo sapiens RUN and SH3 domain containing 1 (RUSC1), transcript variant 1, mRNA. (from RefSeq NM_001105203)
Gencode Transcript: ENST00000368352.10
Gencode Gene: ENSG00000160753.16
Transcript (Including UTRs)
   Position: hg38 chr1:155,320,894-155,331,114 Size: 10,221 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg38 chr1:155,321,774-155,330,571 Size: 8,798 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:155,320,894-155,331,114)mRNA (may differ from genome)Protein (902 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=RUN and SH3 domain-containing protein 1; AltName: Full=New molecule containing SH3 at the carboxy-terminus; Short=Nesca;
FUNCTION: Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF- dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway.
SUBUNIT: Interacts with IKBKG and TRAF6. Interacts with F-actin, acetylated actin, TUBB3, STX1A, KIF5B and KLC1 (By similarity).
INTERACTION: Q9Y6K9:IKBKG; NbExp=4; IntAct=EBI-6257338, EBI-81279; Q9Y4K3:TRAF6; NbExp=2; IntAct=EBI-6257338, EBI-359276;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton (By similarity). Cytoplasmic vesicle (By similarity). Early endosome (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Golgi apparatus (By similarity). Note=Translocated to the nuclear envelope upon stimulation with NGF. Associated with membranes and microtubules (By similarity).
TISSUE SPECIFICITY: Predominantly expressed in brain.
DOMAIN: The RUN domain is necessary for NGF induced nuclear redistribution.
PTM: Phosphorylated on serine residues following nuclear translocation.
PTM: Polyubiquitinated; polyubiquitination involves TRAF6.
SIMILARITY: Contains 1 RUN domain.
SIMILARITY: Contains 1 SH3 domain.
SEQUENCE CAUTION: Sequence=CAI12719.1; Type=Erroneous gene model prediction;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 43.30 RPKM in Brain - Cerebellum
Total median expression: 604.85 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -82.70184-0.449 Picture PostScript Text
3' UTR -126.70543-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004012 - Run
IPR001452 - SH3_domain

Pfam Domains:
PF02759 - RUN domain
PF00018 - SH3 domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q9BVN2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding

Biological Process:
GO:0000209 protein polyubiquitination
GO:0009967 positive regulation of signal transduction

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0030054 cell junction
GO:0031410 cytoplasmic vesicle
GO:0045202 synapse
GO:0045211 postsynaptic membrane

-  Descriptions from all associated GenBank mRNAs
  LF211905 - JP 2014500723-A/19408: Polycomb-Associated Non-Coding RNAs.
MA447482 - JP 2018138019-A/19408: Polycomb-Associated Non-Coding RNAs.
AK125378 - Homo sapiens cDNA FLJ43388 fis, clone OCBBF2007028, highly similar to RUN and SH3 domain-containing protein 1.
BC025680 - Homo sapiens RUN and SH3 domain containing 1, mRNA (cDNA clone IMAGE:5204626), with apparent retained intron.
AK055451 - Homo sapiens cDNA FLJ30889 fis, clone FEBRA2005114, highly similar to Homo sapiens mRNA for NESCA.
AK314559 - Homo sapiens cDNA, FLJ95383, highly similar to Homo sapiens RUN and SH3 domain containing 1 (RUSC1), mRNA.
CR749671 - Homo sapiens mRNA; cDNA DKFZp761A1822 (from clone DKFZp761A1822).
BC052277 - Homo sapiens RUN and SH3 domain containing 1, mRNA (cDNA clone IMAGE:4548018), complete cds.
AK298730 - Homo sapiens cDNA FLJ55745 complete cds, highly similar to RUN and SH3 domain-containing protein 1.
AK093777 - Homo sapiens cDNA FLJ36458 fis, clone THYMU2014599, highly similar to Nesca protein.
AX748300 - Sequence 1825 from Patent EP1308459.
BC001045 - Homo sapiens RUN and SH3 domain containing 1, mRNA (cDNA clone IMAGE:3505458), complete cds.
AK307736 - Homo sapiens cDNA, FLJ97684.
AK074485 - Homo sapiens cDNA FLJ90004 fis, clone HEMBA1000006.
AB026894 - Homo sapiens mRNA for NESCA, complete cds.
AK074982 - Homo sapiens cDNA FLJ90501 fis, clone NT2RP3004067, highly similar to RUN and SH3 domain-containing protein 1.
BC028055 - Homo sapiens, Similar to nesca protein, clone IMAGE:5108891, mRNA.
BC004293 - Homo sapiens, clone IMAGE:3621946, mRNA, partial cds.
BX640612 - Homo sapiens mRNA; cDNA DKFZp686F12178 (from clone DKFZp686F12178).
CU674524 - Synthetic construct Homo sapiens gateway clone IMAGE:100018280 5' read RUSC1 mRNA.
AB590126 - Synthetic construct DNA, clone: pFN21AE1122, Homo sapiens RUSC1 gene for RUN and SH3 domain containing 1, without stop codon, in Flexi system.
DQ895385 - Synthetic construct Homo sapiens clone IMAGE:100009845; FLH183888.01L; RZPDo839H10141D RUN and SH3 domain containing 1 (RUSC1) gene, encodes complete protein.
KJ893417 - Synthetic construct Homo sapiens clone ccsbBroadEn_02811 RUSC1 gene, encodes complete protein.
DQ893622 - Synthetic construct clone IMAGE:100006252; FLH183892.01X; RZPDo839H10142D RUN and SH3 domain containing 1 (RUSC1) gene, encodes complete protein.
AL080083 - Homo sapiens mRNA; cDNA DKFZp564G1762 (from clone DKFZp564G1762); partial cds.
JD228102 - Sequence 209126 from Patent EP1572962.
JD061170 - Sequence 42194 from Patent EP1572962.
JD546198 - Sequence 527222 from Patent EP1572962.
JD182912 - Sequence 163936 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NESCA, NM_001105203, Q5T9U9, Q5T9V1, Q5T9V2, Q9BVN2, Q9UPY4, Q9Y4T5, RUSC1_HUMAN, uc001fkj.1, uc001fkj.2, uc001fkj.3, uc001fkj.4
UCSC ID: uc001fkj.4
RefSeq Accession: NM_001105203
Protein: Q9BVN2 (aka RUSC1_HUMAN or RUS1_HUMAN)
CCDS: CCDS41410.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.