ID:RUSC1_HUMAN DESCRIPTION: RecName: Full=RUN and SH3 domain-containing protein 1; AltName: Full=New molecule containing SH3 at the carboxy-terminus; Short=Nesca; FUNCTION: Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF- dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway. SUBUNIT: Interacts with IKBKG and TRAF6. Interacts with F-actin, acetylated actin, TUBB3, STX1A, KIF5B and KLC1 (By similarity). INTERACTION: Q9Y6K9:IKBKG; NbExp=4; IntAct=EBI-6257338, EBI-81279; Q9Y4K3:TRAF6; NbExp=2; IntAct=EBI-6257338, EBI-359276; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton (By similarity). Cytoplasmic vesicle (By similarity). Early endosome (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Golgi apparatus (By similarity). Note=Translocated to the nuclear envelope upon stimulation with NGF. Associated with membranes and microtubules (By similarity). TISSUE SPECIFICITY: Predominantly expressed in brain. DOMAIN: The RUN domain is necessary for NGF induced nuclear redistribution. PTM: Phosphorylated on serine residues following nuclear translocation. PTM: Polyubiquitinated; polyubiquitination involves TRAF6. SIMILARITY: Contains 1 RUN domain. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=CAI12719.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BVN2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.