Human Gene MTOR (ENST00000361445.9) Description and Page Index
  Description: Homo sapiens mechanistic target of rapamycin kinase (MTOR), mRNA. (from RefSeq NM_004958)
RefSeq Summary (NM_004958): The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U88966.1, AB209995.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361445.9/ ENSP00000354558.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000361445.9
Gencode Gene: ENSG00000198793.13
Transcript (Including UTRs)
   Position: hg38 chr1:11,106,535-11,262,551 Size: 156,017 Total Exon Count: 58 Strand: -
Coding Region
   Position: hg38 chr1:11,107,485-11,259,409 Size: 151,925 Coding Exon Count: 57 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:11,106,535-11,262,551)mRNA (may differ from genome)Protein (2549 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: MTOR_HUMAN
DESCRIPTION: RecName: Full=Serine/threonine-protein kinase mTOR; EC=2.7.11.1; AltName: Full=FK506-binding protein 12-rapamycin complex-associated protein 1; AltName: Full=FKBP12-rapamycin complex-associated protein; AltName: Full=Mammalian target of rapamycin; Short=mTOR; AltName: Full=Mechanistic target of rapamycin; AltName: Full=Rapamycin and FKBP12 target 1; AltName: Full=Rapamycin target protein 1;
FUNCTION: Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B and the inhibitor of translation initiation PDCD4. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 a RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at 'Ser-473' of AKT1, a pro- survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho- type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422'.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
ENZYME REGULATION: Activation of mTORC1 by growth factors such as insulin involves AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase a potent activator of the protein kinase activity of mTORC1. Insulin-stimulated and amino acid-dependent phosphorylation at Ser-1261 promotes autophosphorylation and the activation of mTORC1. Activation by amino acids requires relocalization of the mTORC1 complex to lysosomes that is mediated by the Ragulator complex and the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD. On the other hand, low cellular energy levels can inhibit mTORC1 through activation of PRKAA1 while hypoxia inhibits mTORC1 through a REDD1-dependent mechanism which may also require PRKAA1. The kinase activity of MTOR within the mTORC1 complex is positively regulated by MLST8 and negatively regulated by DEPTOR and AKT1S1. MTOR phosphorylates RPTOR which in turn inhibits mTORC1. mTORC1 binds and is inhibited by the FKBP1A-rapamycin complex. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. It may be regulated by RHEB but in an indirect manner through the PI3K signaling pathway.
SUBUNIT: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Interacts with PPAPDC3 and PML (By similarity). Interacts with PRR5 and RICTOR; the interaction is direct within the mTORC2 complex (By similarity). Interacts with UBQLN1 (By similarity). Interacts with TTI1 and TELO2 (By similarity). Interacts with CLIP1; phosphorylates and regulates CLIP1 (By similarity).
INTERACTION: Q8TB45:DEPTOR; NbExp=5; IntAct=EBI-359260, EBI-2359040; Q13541:EIF4EBP1; NbExp=2; IntAct=EBI-359260, EBI-74090; Q9BVC4:MLST8; NbExp=4; IntAct=EBI-359260, EBI-1387471; Q8TCU6:PREX1; NbExp=11; IntAct=EBI-359260, EBI-1046542; Q6R327:RICTOR; NbExp=17; IntAct=EBI-359260, EBI-1387196; Q8N122:RPTOR; NbExp=12; IntAct=EBI-359260, EBI-1567928; Q96EB6:SIRT1; NbExp=2; IntAct=EBI-359260, EBI-1802965;
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome. Cytoplasm (By similarity). Nucleus, PML body (By similarity). Note=Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB.
TISSUE SPECIFICITY: Expressed in numerous tissues, with highest levels in testis.
PTM: Phosphorylated. Autophosphorylates when part of mTORC1 or mTORC2. Phosphorylation at Ser-1261 promotes autophosphorylation.
SIMILARITY: Belongs to the PI3/PI4-kinase family.
SIMILARITY: Contains 1 FAT domain.
SIMILARITY: Contains 1 FATC domain.
SIMILARITY: Contains 7 HEAT repeats.
SIMILARITY: Contains 1 PI3K/PI4K domain.
SEQUENCE CAUTION: Sequence=AAC39933.1; Type=Frameshift; Positions=956, 999; Sequence=BAE06077.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/FRAP1ID40639ch1p36.html";
WEB RESOURCE: Name=Wikipedia; Note=Mammalian target of rapamycin entry; URL="http://en.wikipedia.org/wiki/Mammalian_target_of_rapamycin";
WEB RESOURCE: Name=Target mTOR; Note=mTOR signaling pathway and mTOR inhibition resource; URL="http://www.targetmtor.com/index.jsp";

-  MalaCards Disease Associations
  MalaCards Gene Search: MTOR
Diseases sorted by gene-association score: smith-kingsmore syndrome* (1580), focal cortical dysplasia, type ii, somatic* (1550), glioblastoma multiforme (24), luminal breast carcinoma (21), tuberous sclerosis (20), subependymal giant cell astrocytoma (18), atopic dermatitis 5 (18), lymphangioleiomyomatosis (16), kidney cancer (15), angiomyolipoma (15), glioblastoma (14), vulvar seborrheic keratosis (14), pancreatic neuroendocrine tumor (13), lung large cell carcinoma (13), laryngomalacia (12), hepatic angiomyolipoma (12), subependymal glioma (12), benign ependymoma (12), hypoxia (12), muscle hypertrophy (12), autosomal dominant polycystic kidney disease (12), diffuse intrinsic pontine glioma (10), paronychia (10), large intestine adenocarcinoma (10), kidney angiomyolipoma (10), umbilical hernia (9), tracheal cancer (9), ewing's family of tumors (9), ovarian clear cell adenocarcinoma (8), renal clear cell carcinoma (8), dermatosis papulosa nigra (8), alexander disease (8), mucositis (8), lymphocele (8), estrogen-receptor positive breast cancer (7), pyogenic granuloma (7), hemimegalencephaly (7), plasmablastic lymphoma (7), stomatitis (7), inverted follicular keratosis (7), mantle cell lymphoma (6), kaposiform hemangioendothelioma (6), keratosis, seborrheic, somatic (6), cytomegalovirus infection (6), megalencephaly (6), mucolipidosis iv (6), large cell acanthoma (6), focal epilepsy (5), corticobasal degeneration (5), endometrial cancer (5), kidney benign neoplasm (5), clear cell adenofibroma (5), kaposi sarcoma (4), exanthem (4), pancreatic cancer (4), renal cell carcinoma (4), spinal cord ependymoma (3), prostate cancer (3), breast cancer (3), fragile x syndrome (2), autoimmune lymphoproliferative syndrome (2), lung cancer (2), hematologic cancer (2), hepatocellular carcinoma (2), intellectual disability (2), intestinal obstruction (2), ovarian cancer, somatic (1), leigh syndrome (1), leukemia, acute myeloid (0)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D020123 Sirolimus
  • C059514 resveratrol
  • C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
  • D019256 Cadmium Chloride
  • D010712 Phosphatidic Acids
  • C401859 temsirolimus
  • C516138 (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine
  • C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • C500530 3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.06 RPKM in Testis
Total median expression: 328.42 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -55.40121-0.458 Picture PostScript Text
3' UTR -251.50950-0.265 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR024585 - DUF3385_TOR
IPR003152 - FATC
IPR009076 - FKBP_rapamycin-assoc_FKBP12-bd
IPR011009 - Kinase-like_dom
IPR000403 - PI3/4_kinase_cat_dom
IPR018936 - PI3/4_kinase_CS
IPR003151 - PIK-rel_kinase_FAT
IPR014009 - PIK_FAT
IPR026683 - TOR/Smg1

Pfam Domains:
PF11865 - Domain of unknown function (DUF3385)
PF02259 - FAT domain
PF02260 - FATC domain
PF00454 - Phosphatidylinositol 3- and 4-kinase
PF08771 - FKBP12-rapamycin binding domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1AUE
- X-ray MuPIT

1FAP
- X-ray

1NSG
- X-ray
To conserve bandwidth, only the images from the first 3 structures are shown.
2FAP - X-ray 2GAQ - NMR MuPIT 2NPU - NMR MuPIT
2RSE - NMR MuPIT 3FAP - X-ray MuPIT 4FAP - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P42345
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
MGIRGDEnsemblEnsemblWormBaseSGD
Protein SequenceProtein Sequence Protein SequenceProtein SequenceProtein Sequence
AlignmentAlignment AlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0001030 RNA polymerase III type 1 promoter DNA binding
GO:0001031 RNA polymerase III type 2 promoter DNA binding
GO:0001032 RNA polymerase III type 3 promoter DNA binding
GO:0001156 TFIIIC-class transcription factor binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:0043022 ribosome binding
GO:0044877 macromolecular complex binding
GO:0051219 phosphoprotein binding

Biological Process:
GO:0001558 regulation of cell growth
GO:0001932 regulation of protein phosphorylation
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0003007 heart morphogenesis
GO:0003179 heart valve morphogenesis
GO:0005979 regulation of glycogen biosynthetic process
GO:0006109 regulation of carbohydrate metabolic process
GO:0006112 energy reserve metabolic process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0007050 cell cycle arrest
GO:0007165 signal transduction
GO:0007281 germ cell development
GO:0007420 brain development
GO:0007569 cell aging
GO:0007584 response to nutrient
GO:0007616 long-term memory
GO:0008361 regulation of cell size
GO:0008542 visual learning
GO:0009267 cellular response to starvation
GO:0009791 post-embryonic development
GO:0010507 negative regulation of autophagy
GO:0010592 positive regulation of lamellipodium assembly
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010831 positive regulation of myotube differentiation
GO:0010942 positive regulation of cell death
GO:0010976 positive regulation of neuron projection development
GO:0014042 positive regulation of neuron maturation
GO:0014736 negative regulation of muscle atrophy
GO:0014823 response to activity
GO:0016241 regulation of macroautophagy
GO:0016242 negative regulation of macroautophagy
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0021510 spinal cord development
GO:0030030 cell projection organization
GO:0030163 protein catabolic process
GO:0030838 positive regulation of actin filament polymerization
GO:0031397 negative regulation of protein ubiquitination
GO:0031529 ruffle organization
GO:0031641 regulation of myelination
GO:0031669 cellular response to nutrient levels
GO:0031929 TOR signaling
GO:0031998 regulation of fatty acid beta-oxidation
GO:0032095 regulation of response to food
GO:0032148 activation of protein kinase B activity
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032868 response to insulin
GO:0032956 regulation of actin cytoskeleton organization
GO:0034198 cellular response to amino acid starvation
GO:0035176 social behavior
GO:0035264 multicellular organism growth
GO:0038202 TORC1 signaling
GO:0040007 growth
GO:0042060 wound healing
GO:0042220 response to cocaine
GO:0043087 regulation of GTPase activity
GO:0043200 response to amino acid
GO:0043276 anoikis
GO:0043278 response to morphine
GO:0043610 regulation of carbohydrate utilization
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045670 regulation of osteoclast differentiation
GO:0045727 positive regulation of translation
GO:0045792 negative regulation of cell size
GO:0045859 regulation of protein kinase activity
GO:0045945 positive regulation of transcription from RNA polymerase III promoter
GO:0046777 protein autophosphorylation
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048255 mRNA stabilization
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0048738 cardiac muscle tissue development
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050769 positive regulation of neurogenesis
GO:0050882 voluntary musculoskeletal movement
GO:0051496 positive regulation of stress fiber assembly
GO:0051549 positive regulation of keratinocyte migration
GO:0051896 regulation of protein kinase B signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0055006 cardiac cell development
GO:0055013 cardiac muscle cell development
GO:0060048 cardiac muscle contraction
GO:0060135 maternal process involved in female pregnancy
GO:0060252 positive regulation of glial cell proliferation
GO:0060999 positive regulation of dendritic spine development
GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0071230 cellular response to amino acid stimulus
GO:0071233 cellular response to leucine
GO:0071456 cellular response to hypoxia
GO:0090335 regulation of brown fat cell differentiation
GO:0090559 regulation of membrane permeability
GO:1900034 regulation of cellular response to heat
GO:1901216 positive regulation of neuron death
GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
GO:1903691 positive regulation of wound healing, spreading of epidermal cells
GO:1904000 positive regulation of eating behavior
GO:1904056 positive regulation of cholangiocyte proliferation
GO:1904058 positive regulation of sensory perception of pain
GO:1904193 negative regulation of cholangiocyte apoptotic process
GO:1904197 positive regulation of granulosa cell proliferation
GO:1904206 positive regulation of skeletal muscle hypertrophy
GO:1904213 negative regulation of iodide transmembrane transport
GO:1904690 positive regulation of cytoplasmic translational initiation
GO:1990253 cellular response to leucine starvation

Cellular Component:
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016605 PML body
GO:0030425 dendrite
GO:0031090 organelle membrane
GO:0031931 TORC1 complex
GO:0031932 TORC2 complex
GO:0032991 macromolecular complex
GO:0043025 neuronal cell body
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  LP830499 - Sequence 1 from Patent EP3211090.
U88966 - Human protein rapamycin associated protein (FRAP2) gene, complete cds.
AB209995 - Homo sapiens mRNA for FRAP1 variant protein, clone: ef01094.
AK302863 - Homo sapiens cDNA FLJ60991 complete cds, highly similar to FKBP12-rapamycin complex-associated protein.
AK304273 - Homo sapiens cDNA FLJ56559 complete cds, highly similar to FKBP12-rapamycin complex-associated protein.
BC117166 - Homo sapiens FK506 binding protein 12-rapamycin associated protein 1, mRNA (cDNA clone MGC:150775 IMAGE:40125717), complete cds.
L34075 - Human FKBP-rapamycin associated protein (FRAP) mRNA, complete cds.
AB384693 - Synthetic construct DNA, clone: pF1KB1123, Homo sapiens FRAP1 gene for FKBP12-rapamycin complex-associated protein, complete cds, without stop codon, in Flexi system.
AK126762 - Homo sapiens cDNA FLJ44809 fis, clone BRACE3044172, highly similar to FKBP12-rapamycin complex-associated protein.
JD506378 - Sequence 487402 from Patent EP1572962.
JD159533 - Sequence 140557 from Patent EP1572962.
JD089021 - Sequence 70045 from Patent EP1572962.
JD105180 - Sequence 86204 from Patent EP1572962.
JD193187 - Sequence 174211 from Patent EP1572962.
JD551053 - Sequence 532077 from Patent EP1572962.
JD368094 - Sequence 349118 from Patent EP1572962.
JD171795 - Sequence 152819 from Patent EP1572962.
JD435342 - Sequence 416366 from Patent EP1572962.
JD249010 - Sequence 230034 from Patent EP1572962.
JD060421 - Sequence 41445 from Patent EP1572962.
HZ473918 - WO 2016002844-A/32: ANTI-INVASIVE/ANTI-METASTATIC DRUG FOR PANCREATIC CANCER CELL.
AK024393 - Homo sapiens cDNA FLJ14331 fis, clone PLACE4000320.
L35478 - Homo sapiens RAPT1 (RAPT1) mRNA, partial cds.
BC127611 - Homo sapiens cDNA clone IMAGE:40031732, partial cds.
HZ473917 - WO 2016002844-A/31: ANTI-INVASIVE/ANTI-METASTATIC DRUG FOR PANCREATIC CANCER CELL.
HW795841 - JP 2014527827-A/1: Novel use of leucyl tRNA synthetase.
LP057243 - Sequence 2 from Patent EP2758775.
HZ473915 - WO 2016002844-A/29: ANTI-INVASIVE/ANTI-METASTATIC DRUG FOR PANCREATIC CANCER CELL.
JD458424 - Sequence 439448 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04012 - ErbB signaling pathway
hsa04150 - mTOR signaling pathway
hsa04910 - Insulin signaling pathway
hsa04920 - Adipocytokine signaling pathway
hsa04930 - Type II diabetes mellitus
hsa05200 - Pathways in cancer
hsa05214 - Glioma
hsa05215 - Prostate cancer
hsa05221 - Acute myeloid leukemia

BioCarta from NCI Cancer Genome Anatomy Project
h_ctcfPathway - CTCF: First Multivalent Nuclear Factor
h_igf1mtorpathway - Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway
h_mTORPathway - mTOR Signaling Pathway
h_bcellsurvivalPathway - B Cell Survival Pathway
h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase
h_stat3Pathway - Stat3 Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein P42345 (Reactome details) participates in the following event(s):

R-HSA-5653968 Ragulator:Rag dimers:SLC38A9 bind mTORC1
R-HSA-198640 TORC2 (mTOR) phosphorylates AKT at S473
R-HSA-2243938 AKT1 E17K mutant is phosphorylated by TORC2 complex
R-HSA-6795290 TORC2 complex phosphorylates SGK1
R-HSA-165680 Formation of active mTORC1 complex
R-HSA-380979 RHEB in mTORC1:RHEB:GTP hydrolyses GTP
R-HSA-447074 AMPK phosphorylates Raptor in the mTORC1 complex
R-HSA-5672843 AKT1S1 (PRAS40) binds mTORC1
R-HSA-5672017 Rheb in the mTORC1 complex hydrolyses GTP
R-HSA-5672817 Active mTORC1 binds the ULK1 complex
R-HSA-5675790 mTORC1 dissociates from ULK complex
R-HSA-5082405 Phosphorylation of HSF1 at Ser326 induces transactivation
R-HSA-5672824 Phosphorylated AKT1S1:mTORC1 binds YWHAB
R-HSA-377186 Activated Akt1 phosphorylates AKT1S1 (PRAS40)
R-HSA-165692 Phosphorylation of 4E-BP1 by activated mTORC1
R-HSA-165718 mTORC1 phosphorylation of RPS6KB1 (S6K)
R-HSA-5672010 Active mTORC1 phosphorylates ULK1
R-HSA-5673768 p-AMPK:AMP phosphorylates Raptor in the mTORC1 complex
R-HSA-8944454 mTORC1 phosphorylates MAF1
R-HSA-5672828 mTORC1 phosphorylates AKT1S1
R-HSA-165159 mTOR signalling
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-162582 Signal Transduction
R-HSA-389356 CD28 co-stimulation
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-6806003 Regulation of TP53 Expression and Degradation
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-1632852 Macroautophagy
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-388841 Costimulation by the CD28 family
R-HSA-194138 Signaling by VEGF
R-HSA-5663202 Diseases of signal transduction
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-166208 mTORC1-mediated signalling
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-3371556 Cellular response to heat stress
R-HSA-1280218 Adaptive Immune System
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-1643685 Disease
R-HSA-212436 Generic Transcription Pathway
R-HSA-6807070 PTEN Regulation
R-HSA-2262752 Cellular responses to stress
R-HSA-168256 Immune System
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: FRAP, FRAP1, FRAP2, MTOR_HUMAN, NM_004958, P42345, Q4LE76, Q5TER1, Q6LE87, Q96QG3, Q9Y4I3, RAFT1, RAPT1, uc001asd.1, uc001asd.2, uc001asd.3, uc001asd.4, uc001asd.5
UCSC ID: uc001asd.5
RefSeq Accession: NM_004958
Protein: P42345 (aka MTOR_HUMAN)
CCDS: CCDS127.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.