Human Gene ZNF318 (ENST00000361428.3) Description and Page Index
Description: Homo sapiens zinc finger protein 318 (ZNF318), mRNA. (from RefSeq NM_014345)
Gencode Transcript: ENST00000361428.3
Gencode Gene: ENSG00000171467.16
Transcript (Including UTRs)
Position: hg38 chr6:43,336,070-43,369,647 Size: 33,578 Total Exon Count: 10 Strand: -
Position: hg38 chr6:43,337,158-43,369,365 Size: 32,208 Coding Exon Count: 10
Data last updated: 2019-09-04
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 318; AltName: Full=Endocrine regulatory protein;
FUNCTION: Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division (By similarity). SUBUNIT: Interacts with the N-terminal domain of AR (By similarity). SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in endocrine tissue. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 2 matrin-type zinc fingers. SEQUENCE CAUTION: Sequence=AAD17298.1; Type=Erroneous initiation; Sequence=AAD47387.1; Type=Frameshift; Positions=4, 44; Sequence=AAH98434.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH98434.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 1214;
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
testosterone-3-carboxymethyloxime-bovine serum albumin conjugate
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR015880 - Znf_C2H2-like
IPR003604 - Znf_U1
ModBase Predicted Comparative 3D Structure on Q5VUA4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC030687 - Homo sapiens zinc finger protein 318, mRNA (cDNA clone IMAGE:4824620). AK027061 - Homo sapiens cDNA: FLJ23408 fis, clone HEP19631, highly similar to AF090114 Homo sapiens unknown mRNA. AF121141 - Homo sapiens endocrine regulator mRNA, complete cds. AF090114 - Homo sapiens unknown mRNA. AK001200 - Homo sapiens cDNA FLJ10338 fis, clone NT2RM2000718, highly similar to Homo sapiens HRIHFB2436 mRNA. JD510422 - Sequence 491446 from Patent EP1572962. JD281013 - Sequence 262037 from Patent EP1572962. JD244074 - Sequence 225098 from Patent EP1572962. JD199125 - Sequence 180149 from Patent EP1572962. AB015342 - Homo sapiens HRIHFB2436 mRNA, partial cds. JD453825 - Sequence 434849 from Patent EP1572962. JD130226 - Sequence 111250 from Patent EP1572962. JD251018 - Sequence 232042 from Patent EP1572962. JD347667 - Sequence 328691 from Patent EP1572962. JD171539 - Sequence 152563 from Patent EP1572962. AK025505 - Homo sapiens cDNA: FLJ21852 fis, clone HEP02238, highly similar to AF121141 Homo sapiens endocrine regulator mRNA. BC098434 - Homo sapiens zinc finger protein 318, mRNA (cDNA clone IMAGE:5920355), partial cds. JD467684 - Sequence 448708 from Patent EP1572962. JD494284 - Sequence 475308 from Patent EP1572962. JD475986 - Sequence 457010 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: HRIHFB2436, NM_014345, O94796, Q4G0E4, Q5VUA4, Q8NEM6, Q9UNU8, Q9Y2W9, uc003oux.1, uc003oux.2, uc003oux.3, uc003oux.4, ZN318_HUMAN UCSC ID: uc003oux.4 RefSeq Accession: NM_014345
(aka ZN318_HUMAN) Q5VUA4
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.