Human Gene ZNF318 (ENST00000361428.3) Description and Page Index
  Description: Homo sapiens zinc finger protein 318 (ZNF318), mRNA. (from RefSeq NM_014345)
Gencode Transcript: ENST00000361428.3
Gencode Gene: ENSG00000171467.16
Transcript (Including UTRs)
   Position: hg38 chr6:43,336,070-43,369,647 Size: 33,578 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg38 chr6:43,337,158-43,369,365 Size: 32,208 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:43,336,070-43,369,647)mRNA (may differ from genome)Protein (2279 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ZN318_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 318; AltName: Full=Endocrine regulatory protein;
FUNCTION: Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division (By similarity).
SUBUNIT: Interacts with the N-terminal domain of AR (By similarity).
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed in endocrine tissue.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Contains 2 matrin-type zinc fingers.
SEQUENCE CAUTION: Sequence=AAD17298.1; Type=Erroneous initiation; Sequence=AAD47387.1; Type=Frameshift; Positions=4, 44; Sequence=AAH98434.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH98434.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 1214;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D019327 Copper Sulfate
  • C045037 testosterone-3-carboxymethyloxime-bovine serum albumin conjugate

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.22 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 301.49 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -183.00282-0.649 Picture PostScript Text
3' UTR -256.701088-0.236 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015880 - Znf_C2H2-like
IPR003604 - Znf_U1

ModBase Predicted Comparative 3D Structure on Q5VUA4
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051321 meiotic cell cycle

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC030687 - Homo sapiens zinc finger protein 318, mRNA (cDNA clone IMAGE:4824620).
AK027061 - Homo sapiens cDNA: FLJ23408 fis, clone HEP19631, highly similar to AF090114 Homo sapiens unknown mRNA.
AF121141 - Homo sapiens endocrine regulator mRNA, complete cds.
AF090114 - Homo sapiens unknown mRNA.
AK001200 - Homo sapiens cDNA FLJ10338 fis, clone NT2RM2000718, highly similar to Homo sapiens HRIHFB2436 mRNA.
JD510422 - Sequence 491446 from Patent EP1572962.
JD281013 - Sequence 262037 from Patent EP1572962.
JD244074 - Sequence 225098 from Patent EP1572962.
JD199125 - Sequence 180149 from Patent EP1572962.
AB015342 - Homo sapiens HRIHFB2436 mRNA, partial cds.
JD453825 - Sequence 434849 from Patent EP1572962.
JD130226 - Sequence 111250 from Patent EP1572962.
JD251018 - Sequence 232042 from Patent EP1572962.
JD347667 - Sequence 328691 from Patent EP1572962.
JD171539 - Sequence 152563 from Patent EP1572962.
AK025505 - Homo sapiens cDNA: FLJ21852 fis, clone HEP02238, highly similar to AF121141 Homo sapiens endocrine regulator mRNA.
BC098434 - Homo sapiens zinc finger protein 318, mRNA (cDNA clone IMAGE:5920355), partial cds.
JD467684 - Sequence 448708 from Patent EP1572962.
JD494284 - Sequence 475308 from Patent EP1572962.
JD475986 - Sequence 457010 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: HRIHFB2436, NM_014345, O94796, Q4G0E4, Q5VUA4, Q8NEM6, Q9UNU8, Q9Y2W9, uc003oux.1, uc003oux.2, uc003oux.3, uc003oux.4, ZN318_HUMAN
UCSC ID: uc003oux.4
RefSeq Accession: NM_014345
Protein: Q5VUA4 (aka ZN318_HUMAN)
CCDS: CCDS4895.2

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.